{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T23:03:41Z","timestamp":1774911821635,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[1996,12,1]],"date-time":"1996-12-01T00:00:00Z","timestamp":849398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1996,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Inhalation of nitric oxide (NO) and prostacyclin (PGI2) may induce selective pulmonary vasodilation and-by improving ventilation-perfusion ratio in ventilated areas of the lung-increase Pao2 in patients with acute lung injury. To assess the therapeutic efficacy of both compounds, dose-response curves were established in patients with adult respiratory distress syndrome (ARDS). Patients received both PGI2 (doses of 1, 10, and 25 ng\/kg\/min) and NO (concentrations of 1, 4, and 8 ppm). Cardiorespiratory parameters were assessed at control, at each drug concentration, and after withdrawal of NO and PGI2. PGI2 resulted in a significant, dose-dependent and selective reduction of pulmonary artery pressure (PAP) from 35.1 +\/- 6.3 mm Hg at control to 33.1 +\/- 4.8 (1 ng\/kg\/min), 31.3 +\/- 4.8 mm Hg (10 ng\/kg\/min) and 29.6 +\/- 4.5 mm Hg (25 ng\/kg\/min), respectively. Inhaled NO reduced PAP from 34.5 +\/- 5.6 to 32.1 +\/- 5.9 mm Hg at 4 ppm, and to 31.8 +\/- 6.1 mm Hg at 8 ppm, respectively, with no effect at 1 ppm. Pao2\/Flo2 ratio increased from 105 +\/- 37 to 125 +\/- 56 mm Hg (range of increase: 0 to 57 mm Hg) at PGI2 10 ng\/kg\/min and to 131 +\/- 63 mm Hg (range: -5 to 89 mm Hg) at 25 ng\/kg\/min with no effect at 1 ng\/kg\/min. NO improved Pao2 (e.g., from 116 +\/- 47 to 167 +\/- 86 mm Hg at 8 ppm) and reduced intrapulmonary shunt at all doses tested. We conclude that both inhaled PGI2 and NO may induce selective pulmonary vasodilation and increase Pao2 in severe ARDS.<\/jats:p>","DOI":"10.1164\/ajrccm.154.6.8970353","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:54:17Z","timestamp":1365098057000},"page":"1671-1677","source":"Crossref","is-referenced-by-count":200,"title":["Inhaled Prostacyclin (PGI2) Versus Inhaled Nitric Oxide in Adult Respiratory Distress Syndrome"],"prefix":"10.1093","volume":"154","author":[{"given":"B","family":"Zwissler","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Kemming","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Habler","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Kleen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Merkel","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Haller","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Briegel","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Welte","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Peter","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1996,12,1]]},"container-title":["American journal of respiratory and critical care medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/154\/6\/1671\/67612277\/ajrccm_154_6_1671.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/154\/6\/1671\/67612277\/ajrccm_154_6_1671.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T05:44:20Z","timestamp":1774676660000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/154\/6\/1671\/8552246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1996,12,1]]},"published-print":{"date-parts":[[1996,12,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm.154.6.8970353","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1996,12]]},"published":{"date-parts":[[1996,12,1]]}}}