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In AA-D subjects, SAC produced a marked eosinophilic inflammatory response at 24 h associated with eosinophil degranulation (eosinophil cationic protein [ECP] in BAL fluid) and lung injury, which largely resolved by Day 16. When the second antigen-challenged segment (SAC performed on Day 2) was lavaged 7 d after challenge (Day 9), a persistent pulmonary eosinophilia was noted accompanied by minimal elevations in ECP and albumin. Eosinophil-active cytokines showed unique patterns: interleukin-5 (IL-5) increased in the antigen segment on Day 2 then returned to baseline after 7 d; granulocyte-macrophage colony-stimulating factor (GM-CSF) peaked at Day 2 but was persistently elevated throughout Day 16 in antigen segments, and increased in control segments at late time points; IL-3 levels were constant and similar in antigen and control segments. Changes were specific to AA-D subjects in comparison with control subjects. Elements of the IgE-mediated pulmonary inflammatory response differ markedly in their development and resolution.<\/jats:p>","DOI":"10.1164\/ajrccm.155.2.9032176","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:54:36Z","timestamp":1365098076000},"page":"442-448","source":"Crossref","is-referenced-by-count":53,"title":["Kinetics of the Development and Recovery of the Lung From IgE-Mediated Inflammation: Dissociation of Pulmonary Eosinophilia, Lung Injury, and Eosinophil-Active Cytokines"],"prefix":"10.1093","volume":"155","author":[{"given":"J R","family":"Shaver","sequence":"first","affiliation":[{"name":"Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107-5083, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J G","family":"Zangrilli","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107-5083, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S K","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107-5083, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R A","family":"Cirelli","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107-5083, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Pollice","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107-5083, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A T","family":"Hastie","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107-5083, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J E","family":"Fish","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107-5083, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S P","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107-5083, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1997,2,1]]},"container-title":["American journal of respiratory and critical care medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/155\/2\/442\/67611372\/ajrccm_155_2_442.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/155\/2\/442\/67611372\/ajrccm_155_2_442.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T05:23:27Z","timestamp":1774675407000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/155\/2\/442\/8552038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1997,2,1]]},"published-print":{"date-parts":[[1997,2,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm.155.2.9032176","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1997,2]]},"published":{"date-parts":[[1997,2,1]]}}}