{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:42:19Z","timestamp":1790692939249,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[1997,2,1]],"date-time":"1997-02-01T00:00:00Z","timestamp":854755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The purpose of this study was to characterize changes in oxygenation, expressed as PaO2\/F(I)O2, when patients with severe acute respiratory failure (PaO2\/F(I)O2 &amp;lt; 150), unrelated to left ventricular failure to atelectasis, were turned to and from a supine to prone position at 1- and 4-h intervals. Ventilator settings were unchanged. Thirty-two consecutive patients were studied 1 h before, 1 and 4 h during and 1 h after placing in a prone position with PaO2\/F(I)O2 of 103 +\/- 28, 158 +\/- 62, 159 +\/- 59, and 128 +\/- 52, respectively (ANOVA, p &amp;lt; 0.001). After 1 h in a prone position, improvement of PaO2\/F(I)O2 by 20 mm Hg or more was considered a positive response. Seven patients studied had no response (22%), hereafter referred to as nonresponders, and 25 had a positive response (78%), hereafter referred to as responders. Among the seven nonresponders, two did not tolerate the prone position and were returned supine before the end of the 4-h trial. With the remaining five, PaO2\/F(I)O2 evolution was 83 +\/- 29, 77 +\/- 19, 83 +\/- 33, and 81 +\/- 47, respectively. For two of the 25 responders, measurements are missing after returning to the supine position. In 10 of the 23 responders (43%) who completed the 4 h prone trial, the PaO2\/F(I)O2 returned to its starting value when patients were repositioned supine: 117 +\/- 24, 164 +\/- 44, 156 +\/- 55, and 110 +\/- 34, respectively (ANOVA, p &amp;lt; 0.01). In 13 of the 23 (57%) improvement persisted: 105 +\/- 27, 187 +\/- 58, 189 +\/- 49, and 157 +\/- 49, respectively (ANOVA, p &amp;lt; 0.001). Repeated improvements after turning to a prone position were frequently observed. Side effects in the 32 patients after a total of 294 periods in a prone position included minor skin injury and edema, two instances of apical atelectasis, one catheter removal, one catheter compression, one extubation, and one transient supraventricular tachycardia.<\/jats:p>","DOI":"10.1164\/ajrccm.155.2.9032181","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:54:36Z","timestamp":1365098076000},"page":"473-478","source":"Crossref","is-referenced-by-count":269,"title":["Prone Position in Mechanically Ventilated Patients With Severe Acute Respiratory Failure"],"prefix":"10.1093","volume":"155","author":[{"given":"G","family":"Chatte","sequence":"first","affiliation":[{"name":"Service de R\u00e9animation Medicale et Assistance Respiratoire, Hopital dela Croix Rousse, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Sab","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation Medicale et Assistance Respiratoire, Hopital dela Croix Rousse, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Dubois","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation Medicale et Assistance Respiratoire, Hopital dela Croix Rousse, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Sirodot","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation Medicale et Assistance Respiratoire, Hopital dela Croix Rousse, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Gaussorgues","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation Medicale et Assistance Respiratoire, Hopital dela Croix Rousse, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Robert","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation Medicale et Assistance Respiratoire, Hopital dela Croix Rousse, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1997,2,1]]},"container-title":["American journal of respiratory and critical care medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/155\/2\/473\/67611217\/ajrccm_155_2_473.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/155\/2\/473\/67611217\/ajrccm_155_2_473.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T05:24:08Z","timestamp":1774675448000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/155\/2\/473\/8551970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1997,2,1]]},"published-print":{"date-parts":[[1997,2,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm.155.2.9032181","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1997,2]]},"published":{"date-parts":[[1997,2,1]]}}}