{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:35:46Z","timestamp":1790519746405,"version":"4.1.0"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[1997,8,1]],"date-time":"1997-08-01T00:00:00Z","timestamp":870393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\u201cZ\u201d is a recently discovered microorganism that may belong to a new genus in the family Chlamydiaceae. Using an ELISA test we developed, we measured levels of serum antibody against \u201cZ\u201d for 308 paired sera obtained from adult patients hospitalized with community-acquired pneumonia (CAP). In 114 patients (37%), serological evidence of past infection with \u201cZ\u201d was found. In eight patients (2.6%) there was serological evidence of acute infection with this pathogen. In four of these eight patients, no other pathogen for CAP was identified despite an intensive serological investigation encompassing 13 etiological agents. The four patients were about 30 yr old, and three of them had no history of chronic illness. Their illness was characterized by high fever, a nonproductive cough, gastrointestinal symptoms, a shift to the left in the white blood cell count, and a prompt, dramatic response to erythromycin therapy. We conclude that the microorganism \u201cZ\u201d, or a close variant, is infectious for humans, in some cases causing CAP. In these cases the disease is mild and responds quickly to treatment with erythromycin.<\/jats:p>","DOI":"10.1164\/ajrccm.156.2.9608081","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T13:25:36Z","timestamp":1365081936000},"page":"578-582","source":"Crossref","is-referenced-by-count":80,"title":["Pneumonia with Serological Evidence of Acute Infection with the Chlamydia-like Microorganism \u201cZ\u201d"],"prefix":"10.1093","volume":"156","author":[{"given":"DAVID","family":"LIEBERMAN","sequence":"first","affiliation":[{"name":"Pulmonary Unit, Division of Internal Medicine, and Department of Virology, Soroka Medical Center of Kupat Holim Klalit and the faculty of the Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SIMONA","family":"KAHANE","sequence":"additional","affiliation":[{"name":"Pulmonary Unit, Division of Internal Medicine, and Department of Virology, Soroka Medical Center of Kupat Holim Klalit and the faculty of the Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DEVORA","family":"LIEBERMAN","sequence":"additional","affiliation":[{"name":"Pulmonary Unit, Division of Internal Medicine, and Department of Virology, Soroka Medical Center of Kupat Holim Klalit and the faculty of the Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MAUREEN G.","family":"FRIEDMAN","sequence":"additional","affiliation":[{"name":"Pulmonary Unit, Division of Internal Medicine, and Department of Virology, Soroka Medical Center of Kupat Holim Klalit and the faculty of the Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1997,8,1]]},"reference":[{"key":"2026032709230649200_B1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1574-6968.1993.tb06189.x","article-title":"Description and partial characterization of a new chlamydia-like microorganism.","volume":"109","author":"Kahane","year":"1993","journal-title":"FEMS Microbiol. Lett."},{"key":"2026032709230649200_B2","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1128\/mr.49.3.298-337.1985","article-title":"Comparative biology of intracellular parasitism.","volume":"49","author":"Moulder","year":"1985","journal-title":"Microbiol. Rev."},{"key":"2026032709230649200_B3","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1128\/mr.55.1.143-190.1991","article-title":"Interaction of Chlamydiae and host cells in vitro.","volume":"55","author":"Moulder","year":"1991","journal-title":"Microbiol. Rev."},{"key":"2026032709230649200_B4","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1574-6968.1995.tb07417.x","article-title":"Evidence that the novel microorganism \u201cZ\u201d may belong to a new genus in the family Chlamydiaceae.","volume":"126","author":"Kahane","year":"1995","journal-title":"FEMS Microbiol. Lett."},{"key":"2026032709230649200_B5","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1136\/thx.51.2.179","article-title":"Multiple pathogens in adult patients admitted with community-acquired pneumonia: a one year prospective study of 346 consecutive patients.","volume":"51","author":"Lieberman","year":"1996","journal-title":"Thorax"},{"key":"2026032709230649200_B6","first-page":"223","article-title":"The use of serum IgA as a diagnostic marker in viral infections.","volume":"1","author":"Friedman","year":"1991","journal-title":"Immunol. Infect. Dis."},{"key":"2026032709230649200_B7","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1007\/BF02098463","article-title":"Evaluation of serological methods in the diagnosis of Chlamydia pneumoniae pneumonia during and epidemic in Finland.","volume":"12","author":"Ekman","year":"1993","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"2026032709230649200_B8","first-page":"756","article-title":"Evaluation of serological methods in the diagnosis of Chlamydia pneumoniae pneumonia during an epidemic in Finland.","volume":"12","author":"Kauppinen","year":"1993","journal-title":"J. Infect. Dis."}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/156\/2\/578\/67448885\/ajrccm_156_2_578.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/156\/2\/578\/67448885\/ajrccm_156_2_578.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T13:23:16Z","timestamp":1774617796000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/156\/2\/578\/8530868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,8,1]]},"references-count":8,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1997,8,1]]},"published-print":{"date-parts":[[1997,8,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm.156.2.9608081","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1997,8]]},"published":{"date-parts":[[1997,8,1]]}}}