{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T02:35:02Z","timestamp":1775097302610,"version":"3.50.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1997,10,1]],"date-time":"1997-10-01T00:00:00Z","timestamp":875664000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Surfactant protein-A (SP-A) leaks into the circulation of patients with acute respiratory distress syndrome (ARDS) or acute cardiogenic pulmonary edema (APE) in a manner inversely related to lung function. Since surfactant protein-B (SP-B) is synthesized as a precursor considerably smaller than alveolar SP-A, we investigated whether it enters the circulation more readily. Reactivities consistent with SP-B proprotein ( \u223c 42 to \u223c 45 kD) and the \u223c 25 kD processing intermediate were detected in plasma. Plasma immunoreactive SP-B levels were significantly higher in ARDS (8,007 \u00b1 1,654 ng\/ml [mean \u00b1 SEM], n = 22) and APE (3,646 \u00b1 635 ng\/ml, n = 10) patients compared with normal subjects (1,685 \u00b1 58 ng\/ml, n = 33) and ventilated patients with no cardiorespiratory disease (1,829 \u00b1 184 ng\/ml, n = 7). All groups had plasma SP-B\/SP-A ratios \u223c 6- to \u223c 8-fold higher than in normal lavage or ARDS tracheal aspirate fluid, consistent with protein sieving. During admission, both plasma SP-B and the SP-B\/SP-A ratio were inversely related to blood oxygenation (PaO2\/FiO2) (p &amp;lt; 0.0001 and p &amp;lt; 0.025, n = 260 from 39 patients; Spearman) and static respiratory system compliance ( \u0394 V\/ \u0394 P) (p &amp;lt; 0.0001 and p &amp;lt; 0.01, n = 168 from 25 patients). We describe in detail three patients and conclude that immunoreactive SP-B enters more readily than SP-A, is cleared acutely, and provides a better indicator of lung trauma.<\/jats:p>","DOI":"10.1164\/ajrccm.156.4.9603061","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T13:26:28Z","timestamp":1365081988000},"page":"1217-1229","source":"Crossref","is-referenced-by-count":114,"title":["Surfactant Proteins-A and -B Are Elevated in Plasma of Patients with Acute Respiratory Failure"],"prefix":"10.1093","volume":"156","author":[{"given":"IAN R.","family":"DOYLE","sequence":"first","affiliation":[{"name":"Departments of Human Physiology and Critical Care Medicine, School of Medicine, Flinders Medical Centre, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDREW D.","family":"BERSTEN","sequence":"additional","affiliation":[{"name":"Departments of Human Physiology and Critical Care Medicine, School of Medicine, Flinders Medical Centre, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TERENCE E.","family":"NICHOLAS","sequence":"additional","affiliation":[{"name":"Departments of Human Physiology and Critical Care Medicine, School of Medicine, Flinders Medical Centre, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1997,10,1]]},"reference":[{"key":"2026032709205387800_B1","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1164\/ajrccm\/148.5.1194","article-title":"Role of tidal volume, FRC, and end-inspiratory volume in the development of pulmonary edema following mechanical ventilation.","volume":"148","author":"Dreyfuss","year":"1993","journal-title":"Am. 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Structural homology with the complement factor Clq.","volume":"201","author":"Voss","year":"1988","journal-title":"J. Mol. Biol"},{"key":"2026032709205387800_B9","doi-asserted-by":"crossref","first-page":"6917","DOI":"10.1021\/bi00242a015","article-title":"Surfactant protein B: disulfide bridges, structural properties, and kringle similarities.","volume":"30","author":"Johansson","year":"1991","journal-title":"Biochemistry"},{"key":"2026032709205387800_B10","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/S0006-3495(92)81643-0","article-title":"Lipid bilayer surface association of lung surfactant protein SP-B, amphipathic segment detected by flow immunofluorescence.","volume":"63","author":"Longo","year":"1992","journal-title":"Biophys. J"},{"key":"2026032709205387800_B11","first-page":"L100","article-title":"Processing of hydrophobic pulmonary surfactant protein B in rat type II cells.","volume":"257","author":"Weaver","year":"1989","journal-title":"Am. J. 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