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Eighty-eight symptomatic children and 123 control subjects were randomly selected for further evaluation by skin testing using common indoor and outdoor allergens; serum assays for total IgE and specific IgE; dust samples assayed for mite (Der p 1 Der f 1), cat (Fel d 1), and cockroach (Bla g 2) allergens; and provocation with histamine to test for bronchial hyperreactivity. Forty-eight of the children with symptoms responded to \u2264 3.9 \u03bc mol of histamine and were considered to have asthma. Marginal analysis identified elevated total IgE and dust mite, cat, and cockroach sensitization as significant risk factors for asthma. Using multiple regression, only dust mite sensitization was independently associated with asthma (odds ratio = 6.6; p &amp;lt; 0.0001). Dust from 81% of the houses contained high levels of mite allergen ( &amp;gt; 2 \u03bc g\/g), while \u223c 40% of the children were exposed to cat and 17% were exposed to cockroach allergen. In this population, there was no significant association between asthma and race, socioeconomic status, home smoking, sensitization to outdoor allergens, or allergen concentration in the child's home. In an area where there is a high prevalence of asthma and most houses contain high concentrations of dust mite allergen, sensitization to this allergen is the dominant risk factor for asthma defined as symptomatic bronchial hyperreactivity.<\/jats:p>","DOI":"10.1164\/ajrccm.156.6.9704026","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T13:26:37Z","timestamp":1365081997000},"page":"1760-1764","source":"Crossref","is-referenced-by-count":133,"title":["Sensitization to Dust Mites as a Dominant Risk Factor for Asthma among Adolescents Living in Central Virginia"],"prefix":"10.1093","volume":"156","author":[{"given":"SUSAN P.","family":"SQUILLACE","sequence":"first","affiliation":[{"name":"Departments of Medicine, Pediatrics, Family Practice, and Statistics, University of Virginia, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RICHARD B.","family":"SPORIK","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Pediatrics, Family Practice, and Statistics, University of Virginia, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GARY","family":"RAKES","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Pediatrics, Family Practice, and Statistics, University of Virginia, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NICOLLE","family":"COUTURE","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Pediatrics, Family Practice, and Statistics, University of Virginia, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANDREW","family":"LAWRENCE","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Pediatrics, Family Practice, and Statistics, University of Virginia, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SUSAN","family":"MERRIAM","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Pediatrics, Family Practice, and Statistics, University of Virginia, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JUAN","family":"ZHANG","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Pediatrics, Family Practice, and Statistics, University of Virginia, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"THOMAS A. 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