{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T14:15:38Z","timestamp":1774620938240,"version":"3.50.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Changes in capacitance vessels have important consequences on cardiac filling pressure and fluid volume distribution in patients with sepsis syndrome. Vascular compliance may be evaluated from the slope of the relationship between changes in total blood volume ( \u0394 TBV) and changes in central venous pressure ( \u0394 CVP) during acute volume expansion (450 ml of gelatin fluid over 6 min), i.e., from the \u0394 TBV\/ \u0394 CVP ratio. The mean ratio (ml \u00d7 mm Hg\u2212 \u00a01 \u00d7 kg\u2212 \u00a01) was 2.03 \u00b1 0.21 in control subjects, 1.43 \u00b1 0.25 in mechanically ventilated patients without sepsis syndrome, and 0.94 \u00b1 0.24 in mechanically ventilated patients with sepsis syndrome (p &amp;lt; 0.0001 versus the other two groups). Based on echocardiographic determinations, cardiac performance was constantly found within the normal range (cardiac output ranged from 5.6 \u00b1 1.2 to 6.7 \u00b1 2.0 L\/min in nonseptic patients from 6.8 \u00b1 1.9 to 7.8 \u00b1 2.2 in septic patients). Effective compliance of the total vascular bed is therefore reduced in patients with sepsis syndrome, independently of the hemodynamic modifications due to mechanical ventilation.<\/jats:p>","DOI":"10.1164\/ajrccm.157.1.9704077","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T13:30:55Z","timestamp":1365082255000},"page":"50-56","source":"Crossref","is-referenced-by-count":17,"title":["Determination of Total Effective Vascular Compliance in Patients with Sepsis Syndrome"],"prefix":"10.1093","volume":"157","author":[{"given":"FRAN\u00c7OIS","family":"STEPHAN","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, INSERM U 337; and the Medical Intensive Care Unit, Broussais Hospital, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANA","family":"NOVARA","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, INSERM U 337; and the Medical Intensive Care Unit, Broussais Hospital, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BRUNO","family":"TOURNIER","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, INSERM U 337; and the Medical Intensive Care Unit, Broussais Hospital, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JEAN-MICHEL","family":"MAILLET","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, INSERM U 337; and the Medical Intensive Care Unit, Broussais Hospital, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00c9RARD M.","family":"LONDON","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, INSERM U 337; and the Medical Intensive Care Unit, Broussais Hospital, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MICHEL E.","family":"SAFAR","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, INSERM U 337; and the Medical Intensive Care Unit, Broussais Hospital, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JEAN-YVES","family":"FAGON","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, INSERM U 337; and the Medical Intensive Care Unit, Broussais Hospital, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1998,1,1]]},"reference":[{"key":"2026032709101067300_B1","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1152\/ajplegacy.1966.210.6.1401","article-title":"Hemodynamic changes in endotoxic shock.","volume":"210","author":"Chien","year":"1966","journal-title":"Am. 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