{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:57:53Z","timestamp":1792634273795,"version":"4.5.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[1998,6,1]],"date-time":"1998-06-01T00:00:00Z","timestamp":896659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Lung injury often occurs after hepatoenteric ischemia, with xanthine oxidase (XO, an oxidant-generating enzyme), released from reperfusing liver and intestines, mediating a significant component of this injury. Since pentastarch administration decreases intestinal reperfusion injury, we determined whether resuscitation with PentaLyte (a pentastarch-containing solution) would decrease hepatoenteric reperfusion injury, xanthine oxidase release, and concomitant lung injury after aortic occlusion\u2013 reperfusion. Aortic occlusion was established in rabbits for 40 min, and was followed by 3 h of reperfusion, during which either PentaLyte or lactated Ringer's solution-based resuscitation was administered. Sham-operated animals served as controls. Hepatoenteric reperfusion injury, as manifested by release of the enzyme aspartate aminotransferase and decreased gastric intramucosal pH, was significantly (p &amp;lt; 0.0167) attenuated by PentaLyte administration after aortic occlusion\u2013reperfusion, as compared with its occurrence in animals given lactated Ringer's solution. The release of XO after aortic occlusion\u2013reperfusion was 4-fold smaller after PentaLyte administration than after resuscitation with lactated Ringer's solution (p &amp;lt; 0.05). Pulmonary injury, as defined by an increase in bronchoalveolar lavage fluid (BALF) protein content and lactate dehydrogenase (LDH) activity, was 4-fold less after PentaLyte administration following aortic occlusion\u2013reperfusion than after administration of lactated Ringer's solution (p &amp;lt; 0.05). We conclude that remote pulmonary injury is significantly decreased by concomitant PentaLyte-mediated reduction of hepatoenteric reperfusion injury and XO release.<\/jats:p>","DOI":"10.1164\/ajrccm.157.6.9708094","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T13:39:58Z","timestamp":1365082798000},"page":"1982-1990","source":"Crossref","is-referenced-by-count":21,"title":["PentaLyte Decreases Lung Injury after Aortic Occlusion\u2013Reperfusion"],"prefix":"10.1093","volume":"157","author":[{"given":"ROBERT N.","family":"AXON","sequence":"first","affiliation":[{"name":"Departments of Anesthesiology and Comparative Medicine, and the Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MANUEL S.","family":"BAIRD","sequence":"additional","affiliation":[{"name":"Departments of Anesthesiology and Comparative Medicine, and the Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JOHN D.","family":"LANG","sequence":"additional","affiliation":[{"name":"Departments of Anesthesiology and Comparative Medicine, and the Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AMY E.","family":"BRIX","sequence":"additional","affiliation":[{"name":"Departments of Anesthesiology and Comparative Medicine, and the Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VANCE G.","family":"NIELSEN","sequence":"additional","affiliation":[{"name":"Departments of Anesthesiology and Comparative Medicine, and the Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1998,6,1]]},"reference":[{"key":"2026032709172802700_B1","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1097\/00000542-199504000-00027","article-title":"The pathophysiology of aortic cross-clamping and unclamping.","volume":"82","author":"Gelman","year":"1995","journal-title":"Anesthesiology"},{"key":"2026032709172802700_B2"},{"key":"2026032709172802700_B3","first-page":"L394","article-title":"Circulating xanthine oxidase mediates lung neutrophil sequestration after intestinal ischemia-reperfusion.","volume":"263","author":"Terada","year":"1992","journal-title":"Am. J. Physiol."},{"key":"2026032709172802700_B4","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1006\/jsre.1993.1072","article-title":"Gut ischemia mediates lung injury by a xanthine oxidase-dependent neutrophil mechanism.","volume":"54","author":"Koike","year":"1993","journal-title":"J. Surg. Res."},{"key":"2026032709172802700_B5","first-page":"G988","article-title":"Liver ischemia-reperfusion increases pulmonary permeability in the rat: role of circulating xanthine oxidase.","volume":"268","author":"Weinbroum","year":"1995","journal-title":"Am. J. Physiol."},{"key":"2026032709172802700_B6","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1097\/00003246-199608000-00012","article-title":"Gastric intramucosal pH and multiple organ injury: impact of ischemia-reperfusion and xanthine oxidase.","volume":"24","author":"Nielsen","year":"1996","journal-title":"Crit. Care Med."},{"key":"2026032709172802700_B7","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1164\/ajrccm.154.5.8912749","article-title":"Lung injury after hepatoenteric ischemia-reperfusion: role of xanthine oxidase.","volume":"154","author":"Nielsen","year":"1996","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2026032709172802700_B8","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1097\/00003246-199706000-00023","article-title":"Xanthine oxidase mediates myocardial injury after hepatoenteric ischemia-perfusion.","volume":"25","author":"Nielsen","year":"1997","journal-title":"Crit. Care Med."},{"key":"2026032709172802700_B9","first-page":"87","article-title":"Xanthine oxidase: biochemistry, distribution and physiology.","volume":"548","author":"Parks","year":"1986","journal-title":"Acta Physiol. Scand."},{"key":"2026032709172802700_B10","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1001\/archsurg.1990.01410190128022","article-title":"Hydroxyethyl starch macromolecules reduce myocardial reperfusion injury.","volume":"125","author":"Zirka","year":"1990","journal-title":"Arch. Surg."},{"key":"2026032709172802700_B11","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0002-9610(91)90203-P","article-title":"Hydroxyethyl starch macromolecules and superoxide dismutase effects on myocardial reperfusion injury.","volume":"162","author":"Oz","year":"1991","journal-title":"Am. J. Surg."},{"key":"2026032709172802700_B12","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/00000542-199207000-00013","article-title":"Temporary cerebral ischemia, effects of pentastarch or albumin on reperfusion injury.","volume":"77","author":"Schell","year":"1992","journal-title":"Anesthesiology"},{"key":"2026032709172802700_B13","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1006\/mvre.1995.1039","article-title":"Attenuation of microvascular permeability dysfunction in postischemic striated muscle by hydroxyethyl starch.","volume":"50","author":"Oz","year":"1995","journal-title":"Microvasc. Res."},{"key":"2026032709172802700_B14","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1097\/00003246-198912000-00012","article-title":"Macromolecules reduce abnormal microvascular permeability in rat limb ischemia-reperfusion injury.","volume":"17","author":"Zirka","year":"1989","journal-title":"Crit. Care Med."},{"key":"2026032709172802700_B15","first-page":"216","article-title":"Pentafraction-Du Pont versus albumin for resuscitation of a lethal intestinal ischemic shock in rats.","volume":"33","author":"Wilms","year":"1991","journal-title":"Circ. Shock"},{"key":"2026032709172802700_B16","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0891-5849(90)90030-M","article-title":"An ESR study of the nitroxide radical of pentastarch-conjugated deferoxamine.","volume":"9","author":"Pieper","year":"1990","journal-title":"Free Radic. Biol. Med."},{"key":"2026032709172802700_B17","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0022-4804(82)90007-5","article-title":"Back diffusion of CO2 and its influence on the intramural pH in gastric mucosa.","volume":"33","author":"Fiddian-Green","year":"1982","journal-title":"J. Surg. Res."},{"key":"2026032709172802700_B18","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1093\/ajcp\/34.4_ts.381","article-title":"Revised spectrophotometric methods for the determination of glutamic-oxalacetic transaminase, glutamic-pyruvic transaminase and lactic acid dehydrogenase.","volume":"34","author":"Henry","year":"1960","journal-title":"Am. J. Clin. Pathol."},{"key":"2026032709172802700_B19","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1093\/clinchem\/13.4.314","article-title":"Rapid enzymatic measurement of blood lactate and pyruvate.","volume":"13","author":"Marbach","year":"1967","journal-title":"Clin. Chem."},{"key":"2026032709172802700_B20","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1203\/00006450-199309000-00013","article-title":"Physiological levels of uric acid inhibit xanthine oxidase in human plasma.","volume":"34","author":"Tan","year":"1993","journal-title":"Pediatr. Res."},{"key":"2026032709172802700_B21","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid.","volume":"150","author":"Smith","year":"1985","journal-title":"Anal. Biochem."},{"key":"2026032709172802700_B22"},{"key":"2026032709172802700_B23","first-page":"G768","article-title":"Conversion of xanthine dehydrogenase to oxidase in ischemic rat intestine: a reevaluation.","volume":"254","author":"Parks","year":"1988","journal-title":"Am. J. Physiol."},{"key":"2026032709172802700_B24","first-page":"1201","article-title":"Xanthine oxidase activity in rat pulmonary artery endothelial cells and its alteration by activated neutrophils.","volume":"134","author":"Phan","year":"1989","journal-title":"Am. J. Pathol."},{"key":"2026032709172802700_B25","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1042\/bj2890523","article-title":"Binding of human xanthine oxidase to sulphated glycosaminoglycans on the endothelial-cell surface.","volume":"289","author":"Adachi","year":"1993","journal-title":"Biochem. J."},{"key":"2026032709172802700_B26","first-page":"G564","article-title":"Circulating xanthine oxidase: potential mediator of ischemic injury.","volume":"258","author":"Yokoyama","year":"1990","journal-title":"Am. J. Physiol."},{"key":"2026032709172802700_B27","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/0741-5214(88)90340-0","article-title":"Renal vasoconstriction and transient declamp hypotension after infrenal aortic occlusion: role of plasma purine degradation products.","volume":"7","author":"Frank","year":"1988","journal-title":"J. Vasc. Surg."},{"key":"2026032709172802700_B28","first-page":"227","article-title":"Changes in acid-base status, lactate concentration and purine metabolites during reconstructive aortic surgery.","volume":"151","author":"Schoenberg","year":"1985","journal-title":"Acta Chir. Scand."},{"key":"2026032709172802700_B29","first-page":"G567","article-title":"Xanthine oxidase and neutrophil infiltration in intestinal ischemia.","volume":"251","author":"Grisham","year":"1986","journal-title":"Am. J. Physiol."},{"key":"2026032709172802700_B30"},{"key":"2026032709172802700_B31","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1097\/00000658-198812000-00015","article-title":"Lower torso ischemia-induced lung injury is leukocyte dependent.","volume":"208","author":"Klausner","year":"1988","journal-title":"Ann. Surg."}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/157\/6\/1982\/67447886\/ajrccm_157_6_1982.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/157\/6\/1982\/67447886\/ajrccm_157_6_1982.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T13:17:34Z","timestamp":1774617454000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/157\/6\/1982\/8531337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,6,1]]},"references-count":31,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1998,6,1]]},"published-print":{"date-parts":[[1998,6,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm.157.6.9708094","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1998,6]]},"published":{"date-parts":[[1998,6,1]]}}}