{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T14:14:31Z","timestamp":1774620871558,"version":"3.50.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1998,9,1]],"date-time":"1998-09-01T00:00:00Z","timestamp":904608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We examined whether the adverse effects of prenatal exposure to tobacco on lung development are limited to the last weeks of gestation by comparing respiratory function in preterm infants whose mothers had and had not smoked during pregnancy. Maximal forced expiratory flow (V\u0307max FRC) and time to peak tidal expiratory flow as a proportion of total expiratory time (Tptef:Te) were measured prior to discharge from hospital in 108 preterm infants (mean [SD] gestational age, 33.5 [1.8] wk), 40 of whose mothers had smoked during pregnancy. Infant urinary cotinine was less than 4 ng\/ml in those born to nonsmokers, but it was as high as 458 ng\/ml in exposed infants (p &amp;lt; 0.0001). Tptef:Te was significantly lower in infants exposed to tobacco in utero (mean [SD], 0.369 [0.109]) when compared with those who were not (0.426 [0.135]) (p \u2264 0.02). V\u0307max FRC was also reduced in exposed infants (mean [SD], 85.2 [41.7] ml\/s versus 103.8 [49.7] ml\/s) (p = 0.07). After allowing for sex, ethnic group, body size, postnatal age, and socioeconomic status, Tptef:Te remained significantly diminished in infants exposed prenatally to tobacco (p &amp;lt; 0.05). Thus, impaired respiratory function is evident in infants born on average 7 wk prior to the expected delivery date, suggesting that the adverse effects of prenatal exposure to tobacco are not limited to the last weeks of pregnancy.<\/jats:p>","DOI":"10.1164\/ajrccm.158.3.9711057","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T13:45:28Z","timestamp":1365083128000},"page":"700-705","source":"Crossref","is-referenced-by-count":167,"title":["Respiratory Function Among Preterm Infants Whose Mothers Smoked During Pregnancy"],"prefix":"10.1093","volume":"158","author":[{"given":"AH-FONG","family":"HOO","sequence":"first","affiliation":[{"name":"Portex Anaesthesia, Intensive Therapy and Respiratory Medicine Unit, Department of Epidemiology and Public Health, Institute of Child Health; and Department of Child Health, St. Bartholomew's and the Royal London School of Medicine and Dentistry, Homerton Hospital, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MATTHIAS","family":"HENSCHEN","sequence":"additional","affiliation":[{"name":"Portex Anaesthesia, Intensive Therapy and Respiratory Medicine Unit, Department of Epidemiology and Public Health, Institute of Child Health; and Department of Child Health, St. Bartholomew's and the Royal London School of Medicine and Dentistry, Homerton Hospital, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CAROL","family":"DEZATEUX","sequence":"additional","affiliation":[{"name":"Portex Anaesthesia, Intensive Therapy and Respiratory Medicine Unit, Department of Epidemiology and Public Health, Institute of Child Health; and Department of Child Health, St. Bartholomew's and the Royal London School of Medicine and Dentistry, Homerton Hospital, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KATE","family":"COSTELOE","sequence":"additional","affiliation":[{"name":"Portex Anaesthesia, Intensive Therapy and Respiratory Medicine Unit, Department of Epidemiology and Public Health, Institute of Child Health; and Department of Child Health, St. Bartholomew's and the Royal London School of Medicine and Dentistry, Homerton Hospital, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JANET","family":"STOCKS","sequence":"additional","affiliation":[{"name":"Portex Anaesthesia, Intensive Therapy and Respiratory Medicine Unit, Department of Epidemiology and Public Health, Institute of Child Health; and Department of Child Health, St. Bartholomew's and the Royal London School of Medicine and Dentistry, Homerton Hospital, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1998,9,1]]},"reference":[{"key":"2026032709093326000_B1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2105\/AJPH.80.1.29","article-title":"Cigarette smoking as a risk factor for sudden infant death syndrome: a population based study.","volume":"80","author":"Haglund","year":"1990","journal-title":"Am. 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