{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:20:45Z","timestamp":1792005645487,"version":"4.4.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1998,10,1]],"date-time":"1998-10-01T00:00:00Z","timestamp":907200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We investigated airway responsiveness to mannitol, a new hyperosmolar challenge, in persons hyperresponsive to airway drying. We studied 36 asthmatic subjects, 18 to 40 yr of age, responsive to exercise (n = 23) and eucapnic hyperventilation (n = 28) defined by a 10% fall in FEV1. Fifteen subjects performed both challenges. All subjects performed a challenge with dry powder mannitol, encapsulated and delivered via a Dinkihaler until a 15% decrease in FEV1 was documented or a cumulative dose of 635 mg was delivered. All subjects responsive to eucapnic hyperventilation and all but one subject responsive to exercise were responsive to mannitol. Sixty-nine percent of subjects had a positive response to mannitol after less than 155 mg (6 capsules) and 94% less than 320 mg (10 capsules). The provoking dose of mannitol required to cause a 15% fall in FEV1 (PD15) was related to the severity of the response to exercise (Pearson's correlation coefficient [rp] = 0.68, p &amp;lt; 0.01) and eucapnic hyperventilation (rp = 0.68, p &amp;lt; 0.01) in subjects who were not taking inhaled corticosteroids. The mean ( \u00b1 SD) maximum percent fall in FEV1 after mannitol was 24.4 \u00b1 6.2% and recovery to bronchodilator occurred within 10 min in most subjects. The mannitol test is simple, inexpensive, faster to perform than hyperpnea with dry air and could become an office-based test. Further studies are now required to determine the sensitivity of mannitol to identify exercise-induced asthma in a random population.<\/jats:p>","DOI":"10.1164\/ajrccm.158.4.9802087","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T13:47:41Z","timestamp":1365083261000},"page":"1120-1126","source":"Crossref","is-referenced-by-count":137,"title":["Responsiveness to Mannitol in Asthmatic Subjects with Exercise- and Hyperventilation-induced Asthma"],"prefix":"10.1093","volume":"158","author":[{"given":"JOHN D.","family":"BRANNAN","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Royal Prince Alfred Hospital, Camperdown, Australia; Department of Respiratory Medicine, Kuopio University Hospital, Kuopio, Finland; and Department of Pharmacy, University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HEIKKI","family":"KOSKELA","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Royal Prince Alfred Hospital, Camperdown, Australia; Department of Respiratory Medicine, Kuopio University Hospital, Kuopio, Finland; and Department of Pharmacy, University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SANDRA D.","family":"ANDERSON","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Royal Prince Alfred Hospital, Camperdown, Australia; Department of Respiratory Medicine, Kuopio University Hospital, Kuopio, Finland; and Department of Pharmacy, University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NORA","family":"CHEW","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Royal Prince Alfred Hospital, Camperdown, Australia; Department of Respiratory Medicine, Kuopio University Hospital, Kuopio, Finland; and Department of Pharmacy, University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1998,10,1]]},"reference":[{"key":"2026032709043313000_B1","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1136\/adc.47.256.882","article-title":"Standardization of exercise tests in asthmatic children.","volume":"47","author":"Silverman","year":"1972","journal-title":"Arch. 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