{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:32:02Z","timestamp":1790854322371,"version":"4.1.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[1998,11,1]],"date-time":"1998-11-01T00:00:00Z","timestamp":909878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We investigated the expression of adhesion molecules in circulating neutrophils (lymphocyte function-associated antigen-1 [LFA-1], Mac-1, and L-selectin) and endothelial cells (soluble intercellular adhesion molecule-1[sICAM-1]) in 23 patients with stable chronic obstructive pulmonary disease (COPD), 18 subjects with exacerbated COPD, and 23 healthy volunteers. Also, in these circulating neutrophils, we assessed the expression of two G protein subunits (G \u03b1 s and G \u03b1 i1\/2). Compared with control subjects, patients with stable COPD showed increased expression of Mac-1 (p &amp;lt; 0.001) and lower levels of sICAM-1 (p = 0.002); LFA-1 and L-selectin expression was similar in patients and control subjects. During exacerbations, compared with stable patients, the expression of Mac-1 and LFA-1 was reduced (p &amp;lt; 0.001). Finally, the expression of G \u03b1 s (but not G \u03b1 i1\/2) was also reduced (p &amp;lt; 0.001) in circulating neutrophils of patients with COPD, irrespective of the clinical condition of the patient. These results indicate that in patients with COPD: (1) the expression of some neutrophil adhesion molecules (Mac-1) is abnormal, and that this pattern changes during exacerbations; (2) there may be a form of endothelial dysfunction, as suggested by the low sICAM-1 levels; (3) the expression of G protein subunit (G \u03b1 s) in circulating neutrophils is downregulated, irrespective of their clinical conditions. Overall, these results indicate the presence of significant systemic abnormalities in COPD.<\/jats:p>","DOI":"10.1164\/ajrccm.158.5.9712092","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T13:46:57Z","timestamp":1365083217000},"page":"1664-1668","source":"Crossref","is-referenced-by-count":109,"title":["Expression of Adhesion Molecules and G Proteins in Circulating Neutrophils in Chronic Obstructive Pulmonary Disease"],"prefix":"10.1093","volume":"158","author":[{"given":"AINA","family":"NOGUERA","sequence":"first","affiliation":[{"name":"Servei de Pneumologia, Servei de Analisis Cliniques, and Unitat d'Investigaci\u00f3 (REUNI), Hospital Universitari Son Dureta, Palma de Mallorca, Spain; and Respiratory Medicine Unit, Department of Medicine, University of Edinburgh, Royal Infirmary, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XAVIER","family":"BUSQUETS","sequence":"additional","affiliation":[{"name":"Servei de Pneumologia, Servei de Analisis Cliniques, and Unitat d'Investigaci\u00f3 (REUNI), Hospital Universitari Son Dureta, Palma de Mallorca, Spain; and Respiratory Medicine Unit, Department of Medicine, University of Edinburgh, Royal Infirmary, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JAUME","family":"SAULEDA","sequence":"additional","affiliation":[{"name":"Servei de Pneumologia, Servei de Analisis Cliniques, and Unitat d'Investigaci\u00f3 (REUNI), Hospital Universitari Son Dureta, Palma de Mallorca, Spain; and Respiratory Medicine Unit, Department of Medicine, University of Edinburgh, Royal Infirmary, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JOSE  M.","family":"VILLAVERDE","sequence":"additional","affiliation":[{"name":"Servei de Pneumologia, Servei de Analisis Cliniques, and Unitat d'Investigaci\u00f3 (REUNI), Hospital Universitari Son Dureta, Palma de Mallorca, Spain; and Respiratory Medicine Unit, Department of Medicine, University of Edinburgh, Royal Infirmary, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WILLIAM","family":"MacNEE","sequence":"additional","affiliation":[{"name":"Servei de Pneumologia, Servei de Analisis Cliniques, and Unitat d'Investigaci\u00f3 (REUNI), Hospital Universitari Son Dureta, Palma de Mallorca, Spain; and Respiratory Medicine Unit, Department of Medicine, University of Edinburgh, Royal Infirmary, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ALVAR G. 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