{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T14:12:31Z","timestamp":1774620751597,"version":"3.50.1"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[1998,12,1]],"date-time":"1998-12-01T00:00:00Z","timestamp":912470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Bronchial hyperresponsiveness (BHR) and peak expiratory flow (PEF) variability are associated expressions of airway lability, yet probably reflect different underlying pathophysiologic mechanisms. We investigated whether both measures can be used interchangeably to identify subjects who are susceptible to ambient air pollution. Data on BHR ( \u2265 20% fall in FEV1), PEF variability (ampl%mean PEF &amp;gt; 5% on any day during an 8-d period with low air pollution levels) and diary data on upper and lower respiratory symptoms, cough, and phlegm were collected in 189 subjects (48\u201373 yr). The acute effects (lag0) of particulate matter with a diameter less than 10 \u03bc m (PM10), black smoke, SO2 and NO2 on the prevalence of symptoms were estimated with logistic regression. In subjects with airway lability, both when expressed as PEF variability (69%) and BHR (28%), the prevalence of symptoms increased significantly with increasing levels of air pollution, especially in those with the greater PEF variability (n = 55, 29%). We found no such consistent positive associations in adults without airway lability. PEF variability, and to a smaller extent BHR, can be used to identify adults who are susceptible to air pollution. Though odds ratios were rather low (ranging from 1.13 to 1.41), the impact on public health can be substantial because it applies to large populations.<\/jats:p>","DOI":"10.1164\/ajrccm.158.6.9804072","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T13:51:12Z","timestamp":1365083472000},"page":"1848-1854","source":"Crossref","is-referenced-by-count":28,"title":["Peak Expiratory Flow Variability, Bronchial Responsiveness, and Susceptibility to Ambient Air Pollution in Adults"],"prefix":"10.1093","volume":"158","author":[{"given":"MARIKE","family":"BOEZEN","sequence":"first","affiliation":[{"name":"Departments of Epidemiology and Statistics, University of Groningen; Pediatric Pulmonology, and Pulmonology, University Hospital Groningen, Groningen; and Environmental Sciences, Environmental and Occupational Health Unit, University of Wageningen, Wageningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAN","family":"SCHOUTEN","sequence":"additional","affiliation":[{"name":"Departments of Epidemiology and Statistics, University of Groningen; Pediatric Pulmonology, and Pulmonology, University Hospital Groningen, Groningen; and Environmental Sciences, Environmental and Occupational Health Unit, University of Wageningen, Wageningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BERT","family":"RIJCKEN","sequence":"additional","affiliation":[{"name":"Departments of Epidemiology and Statistics, University of Groningen; Pediatric Pulmonology, and Pulmonology, University Hospital Groningen, Groningen; and Environmental Sciences, Environmental and Occupational Health Unit, University of Wageningen, Wageningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JUDITH","family":"VONK","sequence":"additional","affiliation":[{"name":"Departments of Epidemiology and Statistics, University of Groningen; Pediatric Pulmonology, and Pulmonology, University Hospital Groningen, Groningen; and Environmental Sciences, Environmental and Occupational Health Unit, University of Wageningen, Wageningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JORRIT","family":"GERRITSEN","sequence":"additional","affiliation":[{"name":"Departments of Epidemiology and Statistics, University of Groningen; Pediatric Pulmonology, and Pulmonology, University Hospital Groningen, Groningen; and Environmental Sciences, Environmental and Occupational Health Unit, University of Wageningen, Wageningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SASKIA","family":"van der ZEE","sequence":"additional","affiliation":[{"name":"Departments of Epidemiology and Statistics, University of Groningen; Pediatric Pulmonology, and Pulmonology, University Hospital Groningen, Groningen; and Environmental Sciences, Environmental and Occupational Health Unit, University of Wageningen, Wageningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GERARD","family":"HOEK","sequence":"additional","affiliation":[{"name":"Departments of Epidemiology and Statistics, University of Groningen; Pediatric Pulmonology, and Pulmonology, University Hospital Groningen, Groningen; and Environmental Sciences, Environmental and Occupational Health Unit, University of Wageningen, Wageningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BERT","family":"BRUNEKREEF","sequence":"additional","affiliation":[{"name":"Departments of Epidemiology and Statistics, University of Groningen; Pediatric Pulmonology, and Pulmonology, University Hospital Groningen, Groningen; and Environmental Sciences, Environmental and Occupational Health Unit, University of Wageningen, Wageningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DIRKJE","family":"POSTMA","sequence":"additional","affiliation":[{"name":"Departments of Epidemiology and Statistics, University of Groningen; Pediatric Pulmonology, and Pulmonology, University Hospital Groningen, Groningen; and Environmental Sciences, Environmental and Occupational Health Unit, University of Wageningen, Wageningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1998,12,1]]},"reference":[{"key":"2026032709062142500_B1","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1164\/ajrccm\/143.5_Pt_1.916","article-title":"Relationship of airways hyperresponsiveness to respiratory symptoms and diurnal peak flow variation in patients with obstructive lung disease.","volume":"143","author":"Brand","year":"1991","journal-title":"Am. 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