{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T23:59:50Z","timestamp":1778025590878,"version":"3.51.4"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1999,3,1]],"date-time":"1999-03-01T00:00:00Z","timestamp":920246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In epidemiologic studies of asthma there is a group with recent wheeze, but with no airway hyperresponsiveness (AHR), in whom it is unclear whether any significant airway abnormality exists. Exhaled nitric oxide (NO) has been proposed as a measure of airway inflammation. We measured exhaled NO in a population sample of 306 young adults who also underwent bronchial challenge with histamine or a bronchodilator test. Subjects blew into a 3-L Tedlar bag against a 2-mm-diameter resistance to close the soft palate and exclude nasal air. The NO content of expired gas from a single breath was analyzed by chemiluminescent analyzer. Exhaled NO was log-normally distributed in the population sample and duplicate measurements were highly reproducible (intraclass correlation coefficient = 0.98). Exhaled NO correlated significantly with airway responsiveness, measured as the dose-response ratio to histamine (r = 0.39, p &amp;lt; 0.001) and with peripheral blood eosinophils (r = 0.35, p &amp;lt; 0.001). Exhaled NO was significantly greater in asthmatic subjects (geometric mean, 22.2; 95% confidence intervals, 16.1 to 30.7 ppb) than in normal subjects (7.8, 7.1 to 8.4, p &amp;lt; 0.001) or in subjects with wheeze but no AHR (8.8, 7.5 to 10.3, p &amp;lt; 0.001). We conclude that exhaled NO is log-normally distributed, is highly reproducible and discriminates well among subjects, suggesting that it is both a feasible and useful measurement for epidemiologic studies of asthma. The findings suggest that wheeze in the absence of AHR is unlikely to be associated with airway inflammation.<\/jats:p>","DOI":"10.1164\/ajrccm.159.3.9802108","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T13:53:03Z","timestamp":1365083583000},"page":"911-916","source":"Crossref","is-referenced-by-count":90,"title":["Exhaled Nitric Oxide Measurements in a Population Sample of Young Adults"],"prefix":"10.1093","volume":"159","author":[{"given":"CHERYL M.","family":"SALOME","sequence":"first","affiliation":[{"name":"Institute of Respiratory Medicine, University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALYSON M.","family":"ROBERTS","sequence":"additional","affiliation":[{"name":"Institute of Respiratory Medicine, University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NATHAN J.","family":"BROWN","sequence":"additional","affiliation":[{"name":"Institute of Respiratory Medicine, University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOHN","family":"DERMAND","sequence":"additional","affiliation":[{"name":"Institute of Respiratory Medicine, University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GUY B.","family":"MARKS","sequence":"additional","affiliation":[{"name":"Institute of Respiratory Medicine, University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANN J.","family":"WOOLCOCK","sequence":"additional","affiliation":[{"name":"Institute of Respiratory Medicine, University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1999,3,1]]},"reference":[{"key":"2026032708571773900_B1","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1164\/ajrccm\/146.3.633","article-title":"Toward a definition of asthma for epidemiology.","volume":"146","author":"Toelle","year":"1992","journal-title":"Am. 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