{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T14:01:04Z","timestamp":1774620064709,"version":"3.50.1"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1999,4,1]],"date-time":"1999-04-01T00:00:00Z","timestamp":922924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Little is known about the anti-asthmatic effects of powerful anti-inflammatory agents such as aspirin-like drugs. We compared the effects of two aspirin-like drugs with different pharmacologic activities, sodium salicylate (SSA) and indomethacin, with the effect of lysine acetylsalicylate (LASA), inhaled 30 min before challenge, on the early and the late asthmatic response induced by a single dose of allergen causing a 25% decrease in FEV1 in a preliminary challenge. Inhaled SSA partially prevented both the early and late response, providing a protection with respect to placebo of 22 \u00b1 6% in the early phase and 23 \u00b1 9% in the late phase of the response. These values were lower (but not significantly) than those of LASA (41 \u00b1 9% and 39 \u00b1 11%, respectively). In a second group of patients, indomethacin failed to affect the early response, while LASA provided a protection of 31 \u00b1 7%. However, these two drugs were equally effective in reducing the late response (44 \u00b1 18% and 39 \u00b1 17% protection for LASA and indomethacin, respectively). In subjects with an early response, despite being ineffective in preventing allergen-induced bronchoconstriction, indomethacin blocked the allergen-induced increase in bronchial hyperresponsiveness measured 2 h after challenge. We conclude that inhaled salicylates, but not indomethacin, exert a protective activity against the early allergic response. This difference is not explained by the different pattern of cyclooxygenase inhibitory activity of these drugs.<\/jats:p>","DOI":"10.1164\/ajrccm.159.4.9709045","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T13:53:06Z","timestamp":1365083586000},"page":"1228-1233","source":"Crossref","is-referenced-by-count":13,"title":["Different Effects of Inhaled Aspirinlike Drugs on Allergen-Induced Early and Late Asthmatic Responses"],"prefix":"10.1093","volume":"159","author":[{"given":"PIERSANTE","family":"SESTINI","sequence":"first","affiliation":[{"name":"Institute of Respiratory Diseases, University of Siena; Division of Pneumology, Hospital of Garbagnate; and Institute of Cardiovascular and Respiratory Diseases, Ospedale S. Raffaele, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ROSA METELLA","family":"REFINI","sequence":"additional","affiliation":[{"name":"Institute of Respiratory Diseases, University of Siena; Division of Pneumology, Hospital of Garbagnate; and Institute of Cardiovascular and Respiratory Diseases, Ospedale S. Raffaele, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIA GRAZIA","family":"PIERONI","sequence":"additional","affiliation":[{"name":"Institute of Respiratory Diseases, University of Siena; Division of Pneumology, Hospital of Garbagnate; and Institute of Cardiovascular and Respiratory Diseases, Ospedale S. Raffaele, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ADRIANO","family":"VAGHI","sequence":"additional","affiliation":[{"name":"Institute of Respiratory Diseases, University of Siena; Division of Pneumology, Hospital of Garbagnate; and Institute of Cardiovascular and Respiratory Diseases, Ospedale S. Raffaele, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIA","family":"ROBUSCHI","sequence":"additional","affiliation":[{"name":"Institute of Respiratory Diseases, University of Siena; Division of Pneumology, Hospital of Garbagnate; and Institute of Cardiovascular and Respiratory Diseases, Ospedale S. Raffaele, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SEBASTIANO","family":"BIANCO","sequence":"additional","affiliation":[{"name":"Institute of Respiratory Diseases, University of Siena; Division of Pneumology, Hospital of Garbagnate; and Institute of Cardiovascular and Respiratory Diseases, Ospedale S. Raffaele, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1999,4,1]]},"reference":[{"key":"2026032708540746500_B1"},{"key":"2026032708540746500_B2","first-page":"762","article-title":"North of England evidence based guidelines development project: summary version of evidence based guideline for the primary care management in adults.","volume":"312","author":"North of England Asthma Guideline Development Group","year":"1997","journal-title":"B.M.J."},{"key":"2026032708540746500_B3"},{"key":"2026032708540746500_B4","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/0091-6749(92)90109-F","article-title":"Protective activity of inhaled nonsteroidal antiinflammatory drugs on bronchial responsiveness to ultrasonically nebulized water.","volume":"90","author":"Bianco","year":"1992","journal-title":"J. Allergy Clin. Immunol."},{"key":"2026032708540746500_B5","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1183\/09031936.95.08060905","article-title":"Inhaled lysine acetylsalicylate (L-ASA) attenuates the bronchoconstrictor response to adenosine 5\u2032-monophosphate (AMP) in asthmatic subjects.","volume":"8","author":"Crimi","year":"1995","journal-title":"Eur. Respir. J."},{"key":"2026032708540746500_B6","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1183\/09031936.96.09061139","article-title":"Changes in neurokinin A airway responsiveness with inhaled lysine-acetylsalicylate in asthma.","volume":"9","author":"Crimi","year":"1996","journal-title":"Eur. Respir. J."},{"key":"2026032708540746500_B7","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1136\/thx.51.8.799","article-title":"Comparison of three inhaled non-steroidal anti-inflammatory drugs on the airway response to sodium metabisulphite and adenosine 5\u2032-monophosphate challenge in asthma.","volume":"51","author":"Wang","year":"1996","journal-title":"Thorax"},{"key":"2026032708540746500_B8","first-page":"157","article-title":"Inhaled lysine acetylsalicylate (L-ASA) attenuates histamine-induced bronchoconstriction in asthma.","volume":"51","author":"Crimi","year":"1996","journal-title":"Allergy"},{"key":"2026032708540746500_B9","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0091-6749(97)70197-0","article-title":"Protective effect of inhaled lysine acetylsalicylate on allergen-induced early and late asthmatic reactions.","volume":"100","author":"Sestini","year":"1997","journal-title":"J. Allergy Clin. Immunol."},{"key":"2026032708540746500_B10","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1164\/ajrccm.155.1.9001307","article-title":"Effect of inhaled indomethacin on exercise-induced bronchoconstriction in children with asthma.","volume":"155","author":"Shumitzu","year":"1997","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2026032708540746500_B11","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1056\/NEJM198910193211602","article-title":"Protective effect of inhaled furosemide on allergen-induced early and late asthmatic reactions.","volume":"321","author":"Bianco","year":"1989","journal-title":"N. Engl. J. Med."},{"key":"2026032708540746500_B12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01630479","article-title":"New insights into the mode of action of anti-inflammatory drugs.","volume":"44","author":"Vane","year":"1995","journal-title":"Inflamm. Res."},{"key":"2026032708540746500_B13","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0014-2999(89)90156-8","article-title":"Antiinflammatory action of salicylates: aspirin is not a prodrug for salicylate against rat carrageenin pleurisy.","volume":"159","author":"Chiabrando","year":"1989","journal-title":"Eur. J. Pharmacol."},{"key":"2026032708540746500_B14","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1124\/mol.51.6.907","article-title":"Sodium salicylate inhibits cyclo-oxygenase-2 activity independently of transcription factor (nuclear factor kappa B) activation: role of arachidonic acid.","volume":"51","author":"Mitchell","year":"1997","journal-title":"Mol. Pharmacol."},{"key":"2026032708540746500_B15","doi-asserted-by":"crossref","first-page":"7227","DOI":"10.1073\/pnas.82.21.7227","article-title":"Modes of action of aspirin-like drugs.","volume":"82","author":"Abramson","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026032708540746500_B16","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1056\/NEJM199106133242407","article-title":"Nonsteroidal antiinflammatory drugs: differences and similarities.","volume":"324","author":"Brooks","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"2026032708540746500_B17","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1126\/science.8052854","article-title":"Inhibition of NF-kB by sodium salicylate and aspirin.","volume":"265","author":"Kopp","year":"1994","journal-title":"Science"},{"key":"2026032708540746500_B18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0074-7696(08)61873-2","article-title":"NF-kappa B and Rel: participants in a multiform transcriptional regulatory system.","volume":"143","author":"Grilli","year":"1993","journal-title":"Int. Rev. Cytol."},{"key":"2026032708540746500_B19","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1161\/01.CIR.91.7.1914","article-title":"Aspirin inhibits nuclear factor-kB mobilization and monocyte adhesion in stimulated human endothelial cells.","volume":"91","author":"Weber","year":"1995","journal-title":"Circulation"},{"key":"2026032708540746500_B20","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1056\/NEJM199704103361506","article-title":"Transcription factors and inflammatory disease.","volume":"336","author":"Barnes","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"2026032708540746500_B21","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1398-9995.1994.tb00772.x","article-title":"Plasma acetylsalicylic acid and salicylic acid levels during aspirin provocation in aspirin-sensitive subjects.","volume":"49","author":"Dahlen","year":"1994","journal-title":"Allergy"},{"key":"2026032708540746500_B22","first-page":"A387","article-title":"Effect of inhaled non-steroidal anti-inflammatory drugs on blood platelet aggregation (abstract).","volume":"151","author":"Sestini","year":"1995","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2026032708540746500_B23","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1164\/ajrccm.154.6.8970343","article-title":"Bronchial aspirin challenge causes specific eicosanoid response in aspirin-sensitive asthmatics.","volume":"1544","author":"Szczeklik","year":"1996","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2026032708540746500_B24","first-page":"393","article-title":"The late reaction following bronchial provocation with house dust mite allergen: dependence on arachidonic acid metabolism.","volume":"52","author":"Fairfax","year":"1983","journal-title":"Clin. Exp. Immunol."},{"key":"2026032708540746500_B25","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1398-9995.1985.tb00217.x","article-title":"Non-steroid anti-inflammatory drugs in asthma: dangerous or useful therapy?","volume":"40","author":"Joubert","year":"1984","journal-title":"Allergy"},{"key":"2026032708540746500_B26","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1365-2125.1985.tb02671.x","article-title":"Lung function and plasma levels of thromboxane B2, 6.ketoprostaglandin F1-alpha and beta2-thromboglobulin in antigen- induced asthma before and after indomethacin pretreatment.","volume":"19","author":"Shepard","year":"1985","journal-title":"Br. J. Clin. Pharmacol."},{"key":"2026032708540746500_B27","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1152\/jappl.1989.66.2.578","article-title":"Effect of indomethacin on allergen-induced asthmatic response.","volume":"66","author":"Kirby","year":"1989","journal-title":"J. Appl. Physiol."},{"key":"2026032708540746500_B28","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1164\/ajrccm\/141.6.1441","article-title":"Allergen stimulated release of thromboxane A2 and leukotriene E4 in humans: effect of indomethacin.","volume":"141","author":"Sladeck","year":"1990","journal-title":"Am. Rev. Respir. Dis."},{"key":"2026032708540746500_B29","first-page":"424","article-title":"Antiinflammatory-antioxidant treatment with a methane sulfoanilide in allergen-induced asthma.","volume":"66","author":"De Lucia","year":"1991","journal-title":"Ann. Allergy"},{"key":"2026032708540746500_B30","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/0049-3848(85)90095-7","article-title":"Differential inhibition of platelet thromboxane and lung prostacyclin production by sulphopyrazone, acetyl-salicylic acid and indomethacin by human tissues in vitro.","volume":"37","author":"Toivanen","year":"1985","journal-title":"J. Thromb. Res."},{"key":"2026032708540746500_B31","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1006\/pulp.1993.1012","article-title":"Leukotrienes and histamine mediate IgE-dependent contraction of human bronchi: pharmacological evidence obtained with tissues from asthmatic and non-asthmatic subjects.","volume":"6","author":"Bj\u00f6rck","year":"1993","journal-title":"Pulm. Pharmacol."},{"key":"2026032708540746500_B32","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/j.1398-9995.1985.tb00886.x","article-title":"Increased bronchial hypersensitivity after early and late bronchial reactions provoked by allergen inhalation.","volume":"40","author":"Machado","year":"1982","journal-title":"Allergy"},{"key":"2026032708540746500_B33","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/0091-6749(82)90038-0","article-title":"Allergen-induced increase in bronchial responsiveness to histamine: relationship to the late asthmatic response and changes in airway caliber.","volume":"70","author":"Cartier","year":"1982","journal-title":"J. Allergy Clin. Immunol."},{"key":"2026032708540746500_B34","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/0091-6749(88)90077-2","article-title":"Increases in airway responsiveness to histamine precede allergen-induced late asthmatic responses.","volume":"82","author":"Durham","year":"1988","journal-title":"J. Allergy Clin. Immunol."},{"key":"2026032708540746500_B35","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1152\/jappl.1990.69.6.2209","article-title":"Allergen-induced increase in airway responsiveness and inflammation in mild asthma.","volume":"69","author":"Brusasco","year":"1990","journal-title":"J. Appl. Physiol."}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/159\/4\/1228\/67429067\/ajrccm_159_4_1228.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/159\/4\/1228\/67429067\/ajrccm_159_4_1228.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T12:54:29Z","timestamp":1774616069000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/159\/4\/1228\/8529944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,4,1]]},"references-count":35,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1999,4,1]]},"published-print":{"date-parts":[[1999,4,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm.159.4.9709045","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1999,4]]},"published":{"date-parts":[[1999,4,1]]}}}