{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:47:31Z","timestamp":1788191251508,"version":"build-2803163510"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[1999,7,1]],"date-time":"1999-07-01T00:00:00Z","timestamp":930787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acute respiratory distress syndrome (ARDS) is a disease of acute respiratory failure manifested by severe hypoxemia with a high mortality rate. Previous outcome studies of ARDS have assessed survival and\/or pulmonary function as the primary outcome variables. Cognitive or psychological outcomes following ARDS have not been described, despite the possibility that ARDS patients are at risk for brain injury through hypoxemia or other mechanisms. In the current study 55 consecutive ARDS survivors completed a battery of neuropsychological tests and questionnaires regarding health status, cognitive and psychological outcomes at the time of hospital discharge and 1 yr after onset of ARDS. At hospital discharge, 100% (55 of 55) of survivors exhibited cognitive and affective impairments, as well as problems with health status which affected their quality of life. At 1 yr after ARDS, 17 of 55 (30%) patients still exhibited generalized cognitive decline. Forty-three of 55 (78%) patients had all or at least one of the following: impaired memory, attention, concentration and\/or decreased mental processing speed. One year after ARDS a substantial portion of ARDS survivors exhibit impaired health status and cognitive sequelae which may be due to hypoxemia, emboli, inflammation, drug toxicity, and\/or other etiologies.<\/jats:p>","DOI":"10.1164\/ajrccm.160.1.9708059","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T13:59:58Z","timestamp":1365083998000},"page":"50-56","source":"Crossref","is-referenced-by-count":554,"title":["Neuropsychological Sequelae and Impaired Health Status in Survivors of Severe Acute Respiratory Distress Syndrome"],"prefix":"10.1093","volume":"160","author":[{"given":"RAMONA O.","family":"HOPKINS","sequence":"first","affiliation":[{"name":"Department of Medicine, Pulmonary and Critical Care Divisions, LDS Hospital, Salt Lake City; Division of Respiratory, Critical Care, and Occupational (Pulmonary) Medicine, University of Utah School of Medicine, Salt Lake City; and Department of Psychology, Brigham Young University, Provo, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LINDELL K.","family":"WEAVER","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pulmonary and Critical Care Divisions, LDS Hospital, Salt Lake City; Division of Respiratory, Critical Care, and Occupational (Pulmonary) Medicine, University of Utah School of Medicine, Salt Lake City; and Department of Psychology, Brigham Young University, Provo, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DONNA","family":"POPE","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pulmonary and Critical Care Divisions, LDS Hospital, Salt Lake City; Division of Respiratory, Critical Care, and Occupational (Pulmonary) Medicine, University of Utah School of Medicine, Salt Lake City; and Department of Psychology, Brigham Young University, Provo, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"JAMES F.","family":"ORME","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pulmonary and Critical Care Divisions, LDS Hospital, Salt Lake City; Division of Respiratory, Critical Care, and Occupational (Pulmonary) Medicine, University of Utah School of Medicine, Salt Lake City; and Department of Psychology, Brigham Young University, Provo, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ERIN D.","family":"BIGLER","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pulmonary and Critical Care Divisions, LDS Hospital, Salt Lake City; Division of Respiratory, Critical Care, and Occupational (Pulmonary) Medicine, University of Utah School of Medicine, Salt Lake City; and Department of Psychology, Brigham Young University, Provo, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VALERIE","family":"LARSON-LOHR","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pulmonary and Critical Care Divisions, LDS Hospital, Salt Lake City; Division of Respiratory, Critical Care, and Occupational (Pulmonary) Medicine, University of Utah School of Medicine, Salt Lake City; and Department of Psychology, Brigham Young University, Provo, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1999,7,1]]},"reference":[{"key":"2026032708440082700_B1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1378\/chest.60.3.233","article-title":"The adult respiratory distress syndrome: clinical features and factors influencing prognosis, and principles of management.","volume":"60","author":"Petty","year":"1971","journal-title":"Chest"},{"key":"2026032708440082700_B2","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1378\/chest.101.4.1074","article-title":"The adult respiratory distress syndrome: a report of survival and modifying factors.","volume":"101","author":"Suchyta","year":"1992","journal-title":"Chest"},{"key":"2026032708440082700_B3","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1164\/ajrccm\/138.3.720","article-title":"An expanded definition of the adult respiratory distress syndrome.","volume":"138","author":"Murray","year":"1988","journal-title":"Am. Rev. Respir. Dis."},{"key":"2026032708440082700_B4","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1378\/chest.107.6.1721","article-title":"What is acute lung injury? What is ARDS?","volume":"107","author":"Schuster","year":"1995","journal-title":"Chest"},{"key":"2026032708440082700_B5","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1136\/thx.49.6.596","article-title":"Adult respiratory distress syndrome: has there been a change in outcome predictive measures?","volume":"49","author":"Lee","year":"1994","journal-title":"Thorax"},{"key":"2026032708440082700_B6","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1378\/chest.83.1.40","article-title":"The risk factors, incidence, and prognosis of the adult respiratory distress syndrome following septicemia.","volume":"83","author":"Fein","year":"1983","journal-title":"Chest"},{"key":"2026032708440082700_B7","first-page":"485","article-title":"Causes of mortality in patients with the adult respiratory distress syndrome.","volume":"132","author":"Montgomery","year":"1985","journal-title":"Am. Rev. Respir. Dis."},{"key":"2026032708440082700_B8","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1378\/chest.99.5.1232","article-title":"Open lung biopsy does not correlate with pulmonary function after the adult respiratory distress syndrome.","volume":"99","author":"Suchyta","year":"1991","journal-title":"Chest"},{"key":"2026032708440082700_B9","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1001\/jama.1995.03520280052039","article-title":"Improved survival of patients with acute respiratory distress syndrome (ARDS): 1983\u20131993.","volume":"273","author":"Milberg","year":"1995","journal-title":"J.A.M.A."},{"key":"2026032708440082700_B10","first-page":"634","article-title":"Prediction of pulmonary function abnormalities after adult respiratory distress syndrome (ARDS).","volume":"135","author":"Elliott","year":"1987","journal-title":"Am. Rev. Respir. Dis."},{"key":"2026032708440082700_B11","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1164\/ajrccm.149.2.8306022","article-title":"Randomized clinical trial of pressure-controlled inverse ratio ventilation and extracorporeal CO2 removal for adult respiratory distress syndrome.","volume":"149","author":"Morris","year":"1994","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2026032708440082700_B12","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1164\/ajrccm\/139.5.1163","article-title":"Clinical determinants of abnormalities in pulmonary function in survivors of the adult respiratory distress syndrome.","volume":"139","author":"Peters","year":"1989","journal-title":"Am. Rev. Respir. Dis."},{"key":"2026032708440082700_B13"},{"key":"2026032708440082700_B14","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1164\/ajrccm.150.1.8025779","article-title":"Recovery of function in survivors of the acute respiratory distress syndrome.","volume":"150","author":"McHugh","year":"1994","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2026032708440082700_B15","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1017\/S135561770000059X","article-title":"Severe anoxia with and without concomitant brain atrophy and neuropsychological impairments.","volume":"1","author":"Hopkins","year":"1995","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"2026032708440082700_B16"},{"key":"2026032708440082700_B17"},{"key":"2026032708440082700_B18","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1097\/00005650-199210000-00004","article-title":"Comparative measurement sensitivity of short and longer health status instruments.","volume":"30","author":"Katz","year":"1992","journal-title":"Med. Care"},{"key":"2026032708440082700_B19","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1097\/00005650-198807000-00007","article-title":"The MOS short form general health survey: reliability and validity in a patient population.","volume":"26","author":"Stewart","year":"1988","journal-title":"Med. Care"},{"key":"2026032708440082700_B20","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1097\/00005650-198108000-00001","article-title":"The Sickness Impact Profile: development and final revision of a health status measure.","volume":"8","author":"Bergner","year":"1981","journal-title":"Med. Care"},{"key":"2026032708440082700_B21"},{"key":"2026032708440082700_B22"},{"key":"2026032708440082700_B23"},{"key":"2026032708440082700_B24","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1001\/archinte.1982.00340210062015","article-title":"Neuropsychological findings in hypoxemic chronic obstructive pulmonary disease.","volume":"142","author":"Grant","year":"1982","journal-title":"Arch. Intern. Med."},{"key":"2026032708440082700_B25","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1001\/archinte.1984.00350200121018","article-title":"Quality of life and its predictors in patients with mild hypoxemia and chronic obstructive pulmonary disease.","volume":"144","author":"Prigatano","year":"1984","journal-title":"Arch. Intern. Med."},{"key":"2026032708440082700_B26","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1001\/archinte.1983.00350100121023","article-title":"Psychologic effects of continuous and nocturnal oxygen therapy in hypoxemic chronic obstructive pulmonary disease.","volume":"143","author":"Heaton","year":"1983","journal-title":"Arch. Intern. Med."},{"key":"2026032708440082700_B27","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1006\/brcg.1995.1016","article-title":"Item and order recognition memory in subjects with hypoxic brain injury.","volume":"27","author":"Hopkins","year":"1995","journal-title":"Brain Cognition"},{"key":"2026032708440082700_B28","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1017\/S1355617700000552","article-title":"Memory for novel and familiar spatial and linguistic temporal distance information in hypoxic subjects.","volume":"1","author":"Hopkins","year":"1995","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"2026032708440082700_B29","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/341054a0","article-title":"Hippocampal abnormalities in amnesic patients revealed by high-resolution magnetic resonance imaging.","volume":"341","author":"Press","year":"1986","journal-title":"Nature"},{"key":"2026032708440082700_B30","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1378\/chest.90.5.686","article-title":"Cognitive impairments in patients with obstructive sleep apnea and associated hypoxemia.","volume":"90","author":"Findley","year":"1986","journal-title":"Chest"},{"key":"2026032708440082700_B31"},{"key":"2026032708440082700_B32","first-page":"294","article-title":"Critical illness polyneuropathy: clinical aspects and long-term outcome.","volume":"104","author":"Sieser","year":"1992","journal-title":"Wien-Klin-Wochenschr."},{"key":"2026032708440082700_B33","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1097\/00003246-199410000-00028","article-title":"Venous air embolism in patients with pulmonary barotrauma.","volume":"22","author":"Bricker","year":"1994","journal-title":"Crit. Care Med."},{"key":"2026032708440082700_B34","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1097\/00003246-199410000-00004","article-title":"Venous air embolism.","volume":"22","author":"Boysen","year":"1984","journal-title":"Crit. Care Med."}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/160\/1\/50\/67426538\/ajrccm_160_1_50.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/160\/1\/50\/67426538\/ajrccm_160_1_50.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T12:44:19Z","timestamp":1774615459000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/160\/1\/50\/8528309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,7,1]]},"references-count":34,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1999,7,1]]},"published-print":{"date-parts":[[1999,7,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm.160.1.9708059","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1999,7]]},"published":{"date-parts":[[1999,7,1]]}}}