{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T13:59:11Z","timestamp":1774619951268,"version":"3.50.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[1999,11,1]],"date-time":"1999-11-01T00:00:00Z","timestamp":941414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The aim of this study was to examine dose-dependent effects of intranasal application of neuropeptide Y (NPY) on nasal mucosal blood flow, blood content, and intranasal nitric oxide (NO) concentration. Blood flow was measured by laser Doppler flowmetry (LDF) and blood content by rhinomanometry. Mucosal biopsies were taken for investigation of Y1 and Y2 receptor mRNA expression, using the reverse transcriptase\u2013polymerase chain reaction (RT\u2013PCR). Intranasal application of NPY evoked a dose-dependent reduction of nasal mucosal blood flow. Maximal vasoconstriction, seen at 12 nmol, was \u2212 37.5 \u00b1 6.2%, p &amp;lt; 0.05 (n = 9). The vasoconstrictive effect developed within 2 to 4 min and lasted &amp;gt; 17 min. NPY evoked a dose-dependent reduction of nasal airway resistance (NAR) on the ipsilateral side. Maximal decrease was \u2212 24.0 \u00b1 10.0% at 12 nmol, p &amp;lt; 0.05 (n = 9). There was a decrease in nasal NO production on the ipsilateral side after application of NPY 12 nmol ( \u2212 7.4 \u00b1 1.2%, p &amp;lt; 0.05, n = 8). RT\u2013PCR products corresponding to Y1 receptor but not Y2 receptor mRNA were obtained from biopsies of the nasal mucosa. In conclusion, NPY is a potent vasoconstrictor in the human nose reducing mucosal blood flow, as well as the blood content. The effect is probably mediated via Y1 receptors. NPY receptor agonists may prove beneficial in the treatment of the congested nose in allergic or vasomotor rhinitis. Cervin A, \u00d6nnerf\u00e4lt J, Edvinsson L, Grundemar L. Functional effects of neuropeptide Y receptors on blood flow and nitric oxide levels in the human nose.<\/jats:p>","DOI":"10.1164\/ajrccm.160.5.9902102","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T14:07:42Z","timestamp":1365084462000},"page":"1724-1728","source":"Crossref","is-referenced-by-count":28,"title":["Functional Effects of Neuropeptide Y Receptors on Blood Flow and Nitric Oxide Levels in the Human Nose"],"prefix":"10.1093","volume":"160","author":[{"given":"ANDERS","family":"CERVIN","sequence":"first","affiliation":[{"name":"Departments of Oto-Rhino-Laryngology, Head and Neck Surgery, Internal Medicine, and Clinical Pharmacology, Lund University, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JENNY","family":"\u00d6NNERF\u00c4LT","sequence":"additional","affiliation":[{"name":"Departments of Oto-Rhino-Laryngology, Head and Neck Surgery, Internal Medicine, and Clinical Pharmacology, Lund University, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LARS","family":"EDVINSSON","sequence":"additional","affiliation":[{"name":"Departments of Oto-Rhino-Laryngology, Head and Neck Surgery, Internal Medicine, and Clinical Pharmacology, Lund University, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LARS","family":"GRUNDEMAR","sequence":"additional","affiliation":[{"name":"Departments of Oto-Rhino-Laryngology, Head and Neck Surgery, Internal Medicine, and Clinical Pharmacology, Lund University, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1999,11,1]]},"reference":[{"key":"2026032708495267900_B1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1165\/ajrcmb\/3.2.165","article-title":"Neuropeptide Y (NPY) in human nasal mucosa.","volume":"3","author":"Baraniuk","year":"1990","journal-title":"Am. 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