{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:08:46Z","timestamp":1791212926053,"version":"4.1.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Patients with chronic obstructive pulmonary disease (COPD) are at a mechanical disadvantage and should be predisposed to the development of diaphragmatic fatigue when the ventilatory system is stressed by exercise. The purpose of this study was to determine whether patients with moderately severe COPD develop contractile fatigue of the diaphragm after cycle exercise to the limits of tolerance. Twelve male patients with COPD, age 61.4 \u00b1 3.0 yr, participated. Their forced expiratory volume in 1 s (FEV1) was 1.79 \u00b1 0.14 L, 49.6 \u00b1 3.4% of predicted. Patients cycled at 60\u201370% of their predetermined maximal work capacity until they had to stop because of intolerable symptoms. Twitch transdiaphragmatic pressure (Pdi,tw) was measured during cervical magnetic stimulation before and 10, 30, and 60 min after exercise. A persistent fall in Pdi,tw postexercise of \u2265 10% was considered potentially indicative of contractile fatigue of the diaphragm. Patients cycled for 10.2 \u00b1 2.0 min at a workload of 59.9 \u00b1 4.3 W. Patients exercised maximally relative to their capacity reaching a peak oxygen consumption (V\u0307o2) of 108.1 \u00b1 2.8% of the peak V\u0307o2 obtained during a preliminary maximal incremental exercise test. Pdi,tw was not significantly different from baseline at any time postexercise. Pdi,tw was 19.9 \u00b1 1.6 cm H2O at baseline, 19.6 \u00b1 2.0 cm H2O at 10 min postexercise, 18.6 \u00b1 2.0 cm H2O at 30 min postexercise, and 19.5 \u00b1 1.7 cm H2O at 60 min postexercise. In the individual patients, two of the patients had a persistent \u2265 10% fall in Pdi,tw postexercise, potentially indicative of contractile fatigue of the diaphragm. In conclusion, the majority of patients with moderately severe COPD do not develop contractile fatigue of the diaphragm after high-intensity constant workload cycle exercise to the limits of tolerance. Mador MJ, Kufel TJ, Pineda LA, Sharma GK. Diaphragmatic fatigue and high-intensity exercise in patients with chronic obstructive pulmonary disease.<\/jats:p>","DOI":"10.1164\/ajrccm.161.1.9903010","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T14:08:10Z","timestamp":1365084490000},"page":"118-123","source":"Crossref","is-referenced-by-count":90,"title":["Diaphragmatic Fatigue and High-intensity Exercise in Patients with Chronic Obstructive Pulmonary Disease"],"prefix":"10.1093","volume":"161","author":[{"given":"M.","family":"JEFFERY MADOR","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, State University of New York at Buffalo; and VA Western New York Healthcare System, Buffalo, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"THOMAS J.","family":"KUFEL","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, State University of New York at Buffalo; and VA Western New York Healthcare System, Buffalo, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LILIBETH A.","family":"PINEDA","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, State University of New York at Buffalo; and VA Western New York Healthcare System, Buffalo, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GYANENDRA K.","family":"SHARMA","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, State University of New York at Buffalo; and VA Western New York Healthcare System, Buffalo, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,1,1]]},"reference":[{"key":"2026032708351830600_B1","first-page":"253S","article-title":"Factors limiting exercise performance in lung disease: ventilatory insufficiency.","volume":"101","author":"Belman","year":"1992","journal-title":"Chest"},{"key":"2026032708351830600_B2"},{"key":"2026032708351830600_B3","first-page":"236","article-title":"Ventilatory muscle function during exercise in air and oxygen in patients with chronic air-flow limitation.","volume":"132","author":"Bye","year":"1985","journal-title":"Am. 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