{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T05:48:34Z","timestamp":1792302514771,"version":"4.4.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2000,2,1]],"date-time":"2000-02-01T00:00:00Z","timestamp":949363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The six-minute walk test is a submaximal exercise test that can be performed even by a patient with heart failure not tolerating maximal exercise testing. To elucidate the clinical significance and prognostic value of the six-minute walk test in patients with primary pulmonary hypertension (PPH), we sought (1) to assess the relation between distance walked during the six-minute walk test and exercise capacity determined by maximal cardiopulmonary exercise testing, and (2) to investigate the prognostic value of the six-minute walk test in comparison with other noninvasive parameters. The six-minute walk test was performed in 43 patients with PPH, together with echocardiography, right heart catheterization, and measurement of plasma epinephrine and norepinephrine. Symptom-limited cardiopulmonary exercise testing was performed in a subsample of patients (n = 27). Distance walked in 6 min was significantly shorter in patients with PPH than in age- and sex-matched healthy subjects (297 \u00b1 188 versus 655 \u00b1 91 m, p &amp;lt; 0.001). The distance significantly decreased in proportion to the severity of New York Heart Association functional class. The distance walked correlated modestly with baseline cardiac output (r = 0.48, p &amp;lt; 0.05) and total pulmonary resistance (r = \u2212 0.49, p &amp;lt; 0.05), but not significantly with mean pulmonary arterial pressure. In contrast, the distance walked correlated strongly with peak V\u0307o2 (r = 0.70, p &amp;lt; 0.001), oxygen pulse (r = 0.57, p &amp;lt; 0.01), and V\u0307e-Vco2 slope (r = \u2212 0.66, p &amp;lt; 0.001) determined by cardiopulmonary exercise testing. During a mean follow-up period of 21 \u00b1 16 mo, 12 patients died of cardiopulmonary causes. Among noninvasive parameters including clinical, echocardiographic, and neurohumoral parameters, only the distance walked in 6 min was independently related to mortality in PPH by multivariate analysis. Patients walking &amp;lt; 332 m had a significantly lower survival rate than those walking farther, assessed by Kaplan-Meier survival curves (log-rank test, p &amp;lt; 0.01). These results suggest that the six-minute walk test, a submaximal exercise test, reflects exercise capacity determined by maximal cardiopulmonary exercise testing in patients with PPH, and it is the distance walked in 6 min that has a strong, independent association with mortality. Miyamoto S, Nagaya N, Satoh T, Kyotani S, Sakamaki F, Fujita M, Nakanishi N, Miyatake K. Clinical correlates and prognostic significance of six-minute walk test in patients with primary pulmonary hypertension: comparison with cardiopulmonary exercise testing.<\/jats:p>","DOI":"10.1164\/ajrccm.161.2.9906015","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T14:12:05Z","timestamp":1365084725000},"page":"487-492","source":"Crossref","is-referenced-by-count":903,"title":["Clinical Correlates and Prognostic Significance of Six-minute Walk Test in Patients with Primary Pulmonary Hypertension: Comparison with Cardiopulmonary Exercise Testing"],"prefix":"10.1093","volume":"161","author":[{"given":"SHOICHI","family":"MIYAMOTO","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, National Cardiovascular Center, Osaka; and College of Medical Technology, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NORITOSHI","family":"NAGAYA","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, National Cardiovascular Center, Osaka; and College of Medical Technology, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TORU","family":"SATOH","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, National Cardiovascular Center, Osaka; and College of Medical Technology, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SHINGO","family":"KYOTANI","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, National Cardiovascular Center, Osaka; and College of Medical Technology, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FUMIO","family":"SAKAMAKI","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, National Cardiovascular Center, Osaka; and College of Medical Technology, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MASATOSHI","family":"FUJITA","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, National Cardiovascular Center, Osaka; and College of Medical Technology, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NORIFUMI","family":"NAKANISHI","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, National Cardiovascular Center, Osaka; and College of Medical Technology, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KUNIO","family":"MIYATAKE","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, National Cardiovascular Center, Osaka; and College of Medical Technology, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,2,1]]},"reference":[{"key":"2026032708364056800_B1","doi-asserted-by":"crossref","first-page":"216","DOI":"10.7326\/0003-4819-107-2-216","article-title":"Primary pumonary hypertension: a national prospective study.","volume":"107","author":"Rich","year":"1987","journal-title":"Ann. 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