{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:00:04Z","timestamp":1793397604077,"version":"4.5.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2000,5,1]],"date-time":"2000-05-01T00:00:00Z","timestamp":957139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We previously reported an increased risk for bronchial obstructive disease and allergic sensitization up to age 3 in 47 children hospitalized with a respiratory syncytial virus (RSV) bronchiolitis in infancy compared with 93 matched control subjects recruited during infancy. The aims of the present study were to evaluate the occurrences of bronchial obstructive disease and allergic sensitization in these children at age 71\/ 2. All 140 children reported for the follow-up, which included physical examination, skin prick tests, and serum IgE tests for common food and inhaled allergens. The cumulative prevalence of asthma was 30% in the RSV group and 3% in the control group (p &amp;lt; 0.001), and the cumulative prevalence of \u201cany wheezing\u201d was 68% and 34%, respectively (p &amp;lt; 0.001). Asthma during the year prior to follow-up was seen in 23% of the RSV children and 2% in the control subjects (p &amp;lt; 0.001). Allergic sensitization was found in 41% of the RSV children and 22% of the control subjects (p = 0.039). Multivariate evaluation of possible risk factors for asthma and sensitization using a stepwise logistic statistical procedure for all 140 children showed that RSV bronchiolitis had the highest independent risk ratio for asthma (OR: 12.7, 95% CI 3.4 to 47.1) and a significantly elevated independent risk ratio for allergic sensitization (OR: 2.4, 95% CI 1.1 to 5.5). In conclusion, RSV bronchiolitis in infancy severe enough to cause hospitalization was highly associatied with the development of asthma and allergic sensitization up to age 71\/ 2. The results support the theory that the RSV influences the mechanisms involved in the development of asthma and allergy in children.<\/jats:p>","DOI":"10.1164\/ajrccm.161.5.9906076","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T14:16:55Z","timestamp":1365085015000},"page":"1501-1507","source":"Crossref","is-referenced-by-count":880,"title":["Respiratory Syncytial Virus Bronchiolitis in Infancy Is an Important Risk Factor for Asthma and Allergy at Age 7"],"prefix":"10.1093","volume":"161","author":[{"given":"NELE","family":"SIGURS","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Bor\u00e5s Central Hospital, Bor\u00e5s, Sweden; Department of Pediatrics, Sahlgrenska University Hospital, Gothenburg, Sweden; Emergency Department, Reykjavik Hospital, Reykjavik, Iceland; and Department of Pediatrics, Sk\u00f6vde Central Hospital, Sk\u00f6vde, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RAGNAR","family":"BJARNASON","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Bor\u00e5s Central Hospital, Bor\u00e5s, Sweden; Department of Pediatrics, Sahlgrenska University Hospital, Gothenburg, Sweden; Emergency Department, Reykjavik Hospital, Reykjavik, Iceland; and Department of Pediatrics, Sk\u00f6vde Central Hospital, Sk\u00f6vde, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FRIDRIK","family":"SIGURBERGSSON","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Bor\u00e5s Central Hospital, Bor\u00e5s, Sweden; Department of Pediatrics, Sahlgrenska University Hospital, Gothenburg, Sweden; Emergency Department, Reykjavik Hospital, Reykjavik, Iceland; and Department of Pediatrics, Sk\u00f6vde Central Hospital, Sk\u00f6vde, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BENGT","family":"KJELLMAN","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Bor\u00e5s Central Hospital, Bor\u00e5s, Sweden; Department of Pediatrics, Sahlgrenska University Hospital, Gothenburg, Sweden; Emergency Department, Reykjavik Hospital, Reykjavik, Iceland; and Department of Pediatrics, Sk\u00f6vde Central Hospital, Sk\u00f6vde, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,5,1]]},"reference":[{"key":"2026032708400457200_B1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s004310050798","article-title":"International variation in the management of infants hospitalized with respiratory syncytial virus.","volume":"157","author":"Behrendt","year":"1998","journal-title":"Eur. 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