{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T13:23:56Z","timestamp":1774617836967,"version":"3.50.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2000,6,1]],"date-time":"2000-06-01T00:00:00Z","timestamp":959817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We encountered a young woman with severe central sleep apnea caused by a medullary glioma located slightly dorsal to and to the right of the midline, a region not generally associated with CO2 chemosensitivity. The patient had normal spirometric readings, lung volumes, diffusing capacity, maximal inspiratory pressure, and alveolar\u2013arterial oxygen difference. While awake, she displayed marked irregularity in her breathing pattern; her end-tidal CO2 (FetCO2) ranged from 5.3 to 10.9%. During voluntary hyperpnea, she could quickly reduce her FetCO2 to 4.2%, but her Pco2 did not change after administration of acetazolamide or progesterone. Like patients with congenital central hypoventilation syndrome (CCHS), our patient had a relatively intact ventilatory response to exercise; her Pco2 was high at the start of exercise and increased slightly thereafter. In contrast to CCHS patients, however, our patient had an intact hypoxic ventilatory response ( \u0394 Ve\/ \u0394 SaO2 = \u2212 0.37 L\/min\/SaO2). In further contrast to CCHS patients, our patient had a very short breathholding time and described a sensation of air hunger as the factor limiting her breathholding ability. Her heart rate and blood pressure responses to the Valsalva maneuver were normal.<\/jats:p>","DOI":"10.1164\/ajrccm.161.6.9904087","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T14:15:05Z","timestamp":1365084905000},"page":"2100-2106","source":"Crossref","is-referenced-by-count":29,"title":["Respiratory Control and Respiratory Sensation in a Patient with a Ganglioglioma within the Dorsocaudal Brain Stem"],"prefix":"10.1093","volume":"161","author":[{"given":"HAROLD L.","family":"MANNING","sequence":"first","affiliation":[{"name":"Departments of Medicine and Physiology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAMES C.","family":"LEITER","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Physiology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2000,6,1]]},"reference":[{"key":"2026032708411872100_B1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/00005792-197011000-00003","article-title":"Failure of automatic control of ventilation (Ondine's curse): report of an infant born with this syndrome and review of the literature.","volume":"49","author":"Mellins","year":"1970","journal-title":"Medicine"},{"key":"2026032708411872100_B2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0034-5687(93)90006-V","article-title":"Respiratory sensations in subjects who lack a ventilatory response to CO2.","volume":"93","author":"Shea","year":"1993","journal-title":"Respir. 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