{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T13:10:45Z","timestamp":1774617045716,"version":"3.50.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The relationship between increased airway responsiveness and asthma severity in children is unclear. The Childhood Asthma Management Program (CAMP) with 1,041 children with mild to moderate asthma offers an opportunity to relate the concentration of methacholine that causes a 20% fall in FEV1 (PC20) to level of lung function, occurrence of respiratory symptoms, duration of disease, and assessment of severity by clinical staff. Decreasing PC20 was found to be associated with lower levels of lung function (prebronchodilator percent predicted FEV1: r = 0.29, \u03b2 = 3.5, p &amp;lt; 0.001), the occurrence of chronic asthma symptoms, persistent wheezing (odds ratio [OR] = 1.66, p &amp;lt; 0.001), subjective clinical staff assessment of asthma severity (p &amp;lt; 0.001), and longer duration of asthma (r = \u2212 0.11, \u03b2 = \u2212 0.20, p &amp;lt; 0.002). These data provide evidence that the degree of airway responsiveness is linked to disease severity in children with mild to moderate asthma.<\/jats:p>","DOI":"10.1164\/ajrccm.162.1.9811005","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T14:17:08Z","timestamp":1365085028000},"page":"50-56","source":"Crossref","is-referenced-by-count":88,"title":["Relationship between Increased Airway Responsiveness and Asthma Severity in the Childhood Asthma Management Program"],"prefix":"10.1093","volume":"162","author":[{"given":"SCOTT T.","family":"WEISS","sequence":"first","affiliation":[{"name":"Brigham and Women's Hospital, Channing Laboratory, Boston, Massachusetts; Johns Hopkins Center for Clinical Trials, Baltimore, Maryland; and Department of Allergy, Kaiser Permanente Medical Center and Department of Pediatrics, University of California, San Diego, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARK L.","family":"VAN NATTA","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital, Channing Laboratory, Boston, Massachusetts; Johns Hopkins Center for Clinical Trials, Baltimore, Maryland; and Department of Allergy, Kaiser Permanente Medical Center and Department of Pediatrics, University of California, San Diego, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ROBERT S.","family":"ZEIGER","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital, Channing Laboratory, Boston, Massachusetts; Johns Hopkins Center for Clinical Trials, Baltimore, Maryland; and Department of Allergy, Kaiser Permanente Medical Center and Department of Pediatrics, University of California, San Diego, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2000,7,1]]},"reference":[{"key":"2026032708253149700_B1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1164\/ajrccm\/136.1.62","article-title":"The relationship of nonspecific bronchial responsiveness to respiratory symptoms in a random population sample.","volume":"136","author":"Rijcken","year":"1987","journal-title":"Am. Rev. Respir. Dis."},{"key":"2026032708253149700_B2","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1164\/arrd.1987.135.6.1255","article-title":"The relationship of nonspecific bronchial responsiveness to the occurrence of respiratory symptoms and decreased levels of pulmonary function: the Normative Aging Study.","volume":"135","author":"Sparrow","year":"1987","journal-title":"Am. Rev. Respir. Dis."},{"key":"2026032708253149700_B3","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1164\/ajrccm\/137.4.826","article-title":"The relationship between airways responsiveness to histamine and pulmonary function level in a random population sample.","volume":"137","author":"Rijcken","year":"1988","journal-title":"Am. Rev. Respir. Dis."},{"key":"2026032708253149700_B4","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1365-2222.1989.tb02387.x","article-title":"A prospective study of bronchial hyperresponsiveness and respiratory symptoms in a population of Australian schoolchildren.","volume":"19","author":"Peat","year":"1989","journal-title":"Clin. Exp. Allergy"},{"key":"2026032708253149700_B5"},{"key":"2026032708253149700_B6","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1398-9995.1993.tb00714.x","article-title":"Is the allergen-inhalation challenge predictive of the severity of seasonal asthmatic exacerbations?","volume":"48","author":"Crimi","year":"1993","journal-title":"Allergy"},{"key":"2026032708253149700_B7","first-page":"298","article-title":"Grading severity and treatment requirements to control symptoms in asthmatic children and their relationship with airway hyperreactivity to methacholine.","volume":"59","author":"Amaro-Galvez","year":"1987","journal-title":"Ann. Allergy"},{"key":"2026032708253149700_B8","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1475-097X.1994.tb00506.x","article-title":"Pronounced bronchial hyper-responsiveness and asthma severity.","volume":"14","author":"Plaschke","year":"1994","journal-title":"Clin. Physiol."},{"key":"2026032708253149700_B9","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1164\/ajrccm\/140.2.350","article-title":"Nonspecific bronchial reactivity and its relationship to the clinical expression of asthma: a longitudinal study.","volume":"140","author":"Josephs","year":"1989","journal-title":"Am. Rev. Respir. Dis."},{"key":"2026032708253149700_B10"},{"key":"2026032708253149700_B11","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1164\/ajrccm\/143.4_Pt_1.755","article-title":"Effect of atopy on the natural history of symptoms, peak expiratory flow, and bronchial responsiveness in 7- and 8-year-old children with cough and wheeze: a 12-month longitudinal study.","volume":"143","author":"Clough","year":"1991","journal-title":"Am. Rev. Respir. Dis."},{"key":"2026032708253149700_B12","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1183\/09031936.93.05010032","article-title":"A longitudinal study of baseline FEV1 and bronchial responsiveness in patients with asthma.","volume":"5","author":"Josephs","year":"1992","journal-title":"Eur. Respir. J."},{"key":"2026032708253149700_B13","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1183\/09031936.93.03020220","article-title":"Does non-specific bronchial responsiveness indicate the severity of asthma?","volume":"3","author":"Josephs","year":"1990","journal-title":"Eur. Respir. J."},{"key":"2026032708253149700_B14","first-page":"322","article-title":"Correlation between the clinical classification of bronchial asthma severity and the methacholine test in children.","volume":"5","author":"Albornoz","year":"1995","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"2026032708253149700_B15"},{"key":"2026032708253149700_B16","first-page":"237","article-title":"Relationship between bronchial airway responsiveness and clinical severity of asthma.","volume":"17","author":"Olyboyo","year":"1988","journal-title":"Am. J. Med. Sci."},{"key":"2026032708253149700_B17","first-page":"91","article-title":"Childhood Asthma Management Program (CAMP) Research Group. The childhood asthma management program (CAMP): design, rationale, and methods.","volume":"20","author":"Tonascia","year":"1999","journal-title":"Controlled Clin. Trials"},{"key":"2026032708253149700_B18"},{"key":"2026032708253149700_B19","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1164\/ajrccm\/138.6.1386","article-title":"Spirometric prediction equations for Hispanic children and adults in New Mexico.","volume":"135","author":"Coultas","year":"1988","journal-title":"Am. Rev. Respir. Dis."},{"key":"2026032708253149700_B20","first-page":"725","article-title":"Changes in the normal maximal expiratory flow\u2013volume curve with growth and aging.","volume":"127","author":"Knudson","year":"1983","journal-title":"Am. Rev. Respir. Dis."},{"key":"2026032708253149700_B21","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1365-2222.1977.tb01448.x","article-title":"Bronchial reactivity to inhaled histamine: a method and clinical survey.","volume":"7","author":"Cockcroft","year":"1977","journal-title":"Clin. Allergy"},{"key":"2026032708253149700_B22","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1136\/thx.33.6.705","article-title":"Reproducibility and comparison of responses to inhaled histamine and methacholine.","volume":"33","author":"Juniper","year":"1978","journal-title":"Thorax"},{"key":"2026032708253149700_B23"},{"key":"2026032708253149700_B24","first-page":"868","article-title":"Stability of methacholine chloride in bronchial provocation test solutions.","volume":"38","author":"MacDonald","year":"1981","journal-title":"Am. J. Hosp. Pharm."},{"key":"2026032708253149700_B25"},{"key":"2026032708253149700_B26"},{"key":"2026032708253149700_B27"},{"key":"2026032708253149700_B28","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1164\/ajrccm.154.1.8680684","article-title":"Cellular infiltration of the airways in asthma of varying severity.","volume":"154","author":"Synek","year":"1996","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2026032708253149700_B29"},{"key":"2026032708253149700_B30","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1136\/thx.51.5.496","article-title":"Relationship between the inflammatory infiltrate in bronchial biopsy specimens and clinical severity of asthma in study participants treated with inhaled steroids.","volume":"51","author":"Sont","year":"1996","journal-title":"Thorax"},{"key":"2026032708253149700_B31","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1159\/000237047","article-title":"Determinants of asthma severity.","volume":"107","author":"Djukanovic","year":"1995","journal-title":"Int. Arch. Allergy Immunol."},{"key":"2026032708253149700_B32","first-page":"2S","article-title":"Clinical assessment of patients.","volume":"26(Suppl.)","author":"Godard","year":"1998","journal-title":"Eur. Respir. J."}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/162\/1\/50\/67535769\/ajrccm_162_1_50.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/162\/1\/50\/67535769\/ajrccm_162_1_50.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T12:25:43Z","timestamp":1774614343000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/162\/1\/50\/8540622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7,1]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2000,7,1]]},"published-print":{"date-parts":[[2000,7,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm.162.1.9811005","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2000,7]]},"published":{"date-parts":[[2000,7,1]]}}}