{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T02:06:22Z","timestamp":1794103582023,"version":"4.8.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2000,8,1]],"date-time":"2000-08-01T00:00:00Z","timestamp":965088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In mice, respiratory syncytial virus (RSV) infection can enhance the consequences of allergic airway sensitization, resulting in lung eosinophilia and the development of airway hyperresponsiveness (AHR) to inhaled methacholine (MCh). To delineate a role for interleukin-5 (IL-5), interleukin-4 (IL-4), and interferon gamma (IFN- \u03b3) in mediating the effects of RSV infection on subsequent allergic sensitization, we treated BALB\/c mice with anti-IL-5 during acute RSV infection but not during subsequent exposure to ovalbumin (OVA). IL-5-deficient and IL-4-deficient mice were also treated with IL-5 either during acute RSV infection or during the sensitization period. Airway responsiveness to inhaled MCh was assessed and numbers of lung eosinophils were monitored. Anti-IL-5 treatment during RSV infection reduced AHR and lung eosinophilia after subsequent exposure to allergen. In IL-5-deficient or IL-4-deficient mice lung eosinophilia and AHR after RSV infection and allergen exposure were also markedly reduced. IL-5 administration during RSV infection restored the responses to allergen in both IL-5- and IL-4-deficient mice. However, IL-5 administration only during sensitization restored these responses in IL-4-deficient but not in IL-5-deficient animals. IFN- \u03b3 -deficient mice developed AHR and some lung eosinophilia after allergen exposure alone and when RSV infection preceded allergen, these responses were enhanced. We conclude that both IL-5, particularly during acute infection, and IL-4 are critical in mediating the effects of RSV infection on allergic airway sensitization, resulting in the development of AHR and lung eosinophilia.<\/jats:p>","DOI":"10.1164\/ajrccm.162.2.9903057","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T14:23:08Z","timestamp":1365085388000},"page":"380-386","source":"Crossref","is-referenced-by-count":63,"title":["Critical Roles for Interleukin-4 and Interleukin-5 during Respiratory Syncytial Virus Infection in the Development of Airway Hyperresponsiveness after Airway Sensitization"],"prefix":"10.1093","volume":"162","author":[{"given":"J\u00dcRGEN","family":"SCHWARZE","sequence":"first","affiliation":[{"name":"Division of Basic Sciences, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado; Jackson Laboratory, Bar Harbor, Maine; and Max-Planck-Institut f\u00fcr Immunbiologie, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GRZEGORZ","family":"CIESLEWICZ","sequence":"additional","affiliation":[{"name":"Division of Basic Sciences, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado; Jackson Laboratory, Bar Harbor, Maine; and Max-Planck-Institut f\u00fcr Immunbiologie, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANTHONY","family":"JOETHAM","sequence":"additional","affiliation":[{"name":"Division of Basic Sciences, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado; Jackson Laboratory, Bar Harbor, Maine; and Max-Planck-Institut f\u00fcr Immunbiologie, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TOSHIHIDE","family":"IKEMURA","sequence":"additional","affiliation":[{"name":"Division of Basic Sciences, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado; Jackson Laboratory, Bar Harbor, Maine; and Max-Planck-Institut f\u00fcr Immunbiologie, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MIKA J.","family":"M\u00c4KEL\u00c4","sequence":"additional","affiliation":[{"name":"Division of Basic Sciences, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado; Jackson Laboratory, Bar Harbor, Maine; and Max-Planck-Institut f\u00fcr Immunbiologie, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AZZEDDINE","family":"DAKHAMA","sequence":"additional","affiliation":[{"name":"Division of Basic Sciences, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado; Jackson Laboratory, Bar Harbor, Maine; and Max-Planck-Institut f\u00fcr Immunbiologie, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LEONARD D.","family":"SHULTZ","sequence":"additional","affiliation":[{"name":"Division of Basic Sciences, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado; Jackson Laboratory, Bar Harbor, Maine; and Max-Planck-Institut f\u00fcr Immunbiologie, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARINUS C.","family":"LAMERS","sequence":"additional","affiliation":[{"name":"Division of Basic Sciences, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado; Jackson Laboratory, Bar Harbor, Maine; and Max-Planck-Institut f\u00fcr Immunbiologie, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ERWIN W.","family":"GELFAND","sequence":"additional","affiliation":[{"name":"Division of Basic Sciences, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado; Jackson Laboratory, Bar Harbor, Maine; and Max-Planck-Institut f\u00fcr Immunbiologie, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,8,1]]},"reference":[{"key":"2026032708235421800_B1","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/S0022-3476(73)80582-7","article-title":"The association of viral and bacterial respiratory infections with the exacerbation of wheezing in young asthmatic children.","volume":"82","author":"McIntosh","year":"1973","journal-title":"J. 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