{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T13:13:28Z","timestamp":1774617208947,"version":"3.50.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Six months of twice weekly directly observed isoniazid and rifam-picin treatment of latent tuberculosis (TB) infection was implemented to improve the outcome of treatment. A total of 591 infected aborigines without previous tuberculosis or treatment of latent TB infection received twice weekly isoniazid and rifampicin for 6 mo from 1992 to 1995. The outcome was compared with 403 infected aborigines without previous tuberculosis or treatment of latent TB infection who received self-administered isoniazid daily for 1 yr from 1986 to 1989. Of patients, 487 (82%) completed the twice weekly 6-mo regimen compared with 77 (19%) who completed the daily 12-mo regimen. The main reason for incomplete treatment was default. Both groups were followed over a 6-yr period. The rate of tuberculosis in the twice-weekly isoniazid and rifampicin-treated patients was 0.9\/1,000 patient-years compared with 9\/1,000 patient-years in the daily isoniazid-treated patients. The rate of side effects was higher for directly observed treatment patients, 136\/1,000 patient-years of drugs, compared with 39\/ 1,000 patient-years for self-administered treatment patients. Life-threatening side effects such as skin allergic reactions and hepatitis were the same in both groups. A regimen of 52 doses of directly observed twice weekly isoniazid and rifampicin is an effective and well-tolerated regimen to improve the outcome of the treatment of latent tuberculosis infection in a population with a high rate of default with daily self-administered isoniazid.<\/jats:p>","DOI":"10.1164\/ajrccm.162.3.9804117","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T14:23:40Z","timestamp":1365085420000},"page":"989-993","source":"Crossref","is-referenced-by-count":21,"title":["Twice Weekly Isoniazid and Rifampin Treatment of Latent Tuberculosis Infection in Canadian Plains Aborigines"],"prefix":"10.1093","volume":"162","author":[{"given":"BRIAN D.","family":"McNAB","sequence":"first","affiliation":[{"name":"Division of Tuberculosis Control, Department of Medicine, and Department of Community Health and Epidemiology, and Research Center for the Elimination of Tuberculosis, University of Saskatchewan, Saskatoon, Saskatchewan, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DARCY D.","family":"MARCINIUK","sequence":"additional","affiliation":[{"name":"Division of Tuberculosis Control, Department of Medicine, and Department of Community Health and Epidemiology, and Research Center for the Elimination of Tuberculosis, University of Saskatchewan, Saskatoon, Saskatchewan, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RIAZ A.","family":"ALVI","sequence":"additional","affiliation":[{"name":"Division of Tuberculosis Control, Department of Medicine, and Department of Community Health and Epidemiology, and Research Center for the Elimination of Tuberculosis, University of Saskatchewan, Saskatoon, Saskatchewan, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LEONARD","family":"TAN","sequence":"additional","affiliation":[{"name":"Division of Tuberculosis Control, Department of Medicine, and Department of Community Health and Epidemiology, and Research Center for the Elimination of Tuberculosis, University of Saskatchewan, Saskatoon, Saskatchewan, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VERNON H.","family":"HOEPPNER","sequence":"additional","affiliation":[{"name":"Division of Tuberculosis Control, Department of Medicine, and Department of Community Health and Epidemiology, and Research Center for the Elimination of Tuberculosis, University of Saskatchewan, Saskatoon, Saskatchewan, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2000,9,1]]},"reference":[{"key":"2026032708284270500_B1","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1001\/jama.1984.03340340023018","article-title":"Thirty years after isoniazid: its impact on tuberculosis in children and adolescents.","volume":"251","author":"Hsu","year":"1984","journal-title":"J.A.M.A."},{"key":"2026032708284270500_B2","first-page":"942","article-title":"Prophylactic effects of INH on primary tuberculosis in children.","volume":"76","author":"Ferebee","year":"1957","journal-title":"Am. 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