{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:56:56Z","timestamp":1788497816221,"version":"build-2803163510"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The seroprevalence of Chlamydia pneumoniae is increased in chronic obstructive pulmonary disease (COPD), and subjects with COPD are more likely to have a positive polymerase chain reaction for C. pneumoniae in their sputum. It has been suggested that C. pneumoniae may have a role in the pathogenesis of COPD. We undertook immunohistochemistical staining for C. pneumoniae in archival tissue from subjects who had undergone lobectomy for bronchial carcinoma. There were 16 subjects with COPD (FEV1 = 64 \u00b1 8% [mean \u00b1 SD] predicted) and 21 subjects with normal lung function (FEV1 = 95 \u00b1 11% predicted). There was no difference between the two groups in age or smoking history. Tissues from all of the subjects stained positively for C. pneumoniae, but in the subjects with COPD there were 14.5 positive cells per field (magnification \u00d7 400), as compared with 9.3 cells per field in the control subjects (p = 0.02). Fifty-four percent of the macrophages from the subjects with COPD stained positively for C. pneumoniae, as compared with 29% from the control subjects (p &amp;lt; 0.001). A second control group consisted of 18 younger individuals (mean age: 32 yr) who died accidentally. Only 44% of these subjects had positive staining for C. pneumoniae, and the mean number of cells per field was 0.4. These findings suggest that persistent infection with C. pneumoniae is common, and that there is increased immunostaining for C. pneumoniae in COPD. Further studies are necessary to determine whether chronic infection with C. pneumoniae is important in the pathogenesis of COPD.<\/jats:p>","DOI":"10.1164\/ajrccm.162.3.9912134","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T14:23:40Z","timestamp":1365085420000},"page":"1148-1151","source":"Crossref","is-referenced-by-count":60,"title":["Immunohistochemical Staining for\n                    <i>Chlamydia pneumoniae<\/i>\n                    Is Increased in Lung Tissue from Subjects with Chronic Obstructive Pulmonary Disease"],"prefix":"10.1093","volume":"162","author":[{"given":"LIAN","family":"WU","sequence":"first","affiliation":[{"name":"Departments of Medicine, Paediatrics, and Pathology, University of Auckland, Auckland; Department of Histopathology, Green Lane Hospital, Auckland, New Zealand; and Institute of Respiratory Disease, University of Milan, Istitutto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"STEPHEN J. M.","family":"SKINNER","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Paediatrics, and Pathology, University of Auckland, Auckland; Department of Histopathology, Green Lane Hospital, Auckland, New Zealand; and Institute of Respiratory Disease, University of Milan, Istitutto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NEIL","family":"LAMBIE","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Paediatrics, and Pathology, University of Auckland, Auckland; Department of Histopathology, Green Lane Hospital, Auckland, New Zealand; and Institute of Respiratory Disease, University of Milan, Istitutto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JANE C.","family":"VULETIC","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Paediatrics, and Pathology, University of Auckland, Auckland; Department of Histopathology, Green Lane Hospital, Auckland, New Zealand; and Institute of Respiratory Disease, University of Milan, Istitutto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FRANCESCO","family":"BLASI","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Paediatrics, and Pathology, University of Auckland, Auckland; Department of Histopathology, Green Lane Hospital, Auckland, New Zealand; and Institute of Respiratory Disease, University of Milan, Istitutto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PETER N.","family":"BLACK","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Paediatrics, and Pathology, University of Auckland, Auckland; Department of Histopathology, Green Lane Hospital, Auckland, New Zealand; and Institute of Respiratory Disease, University of Milan, Istitutto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,9,1]]},"reference":[{"key":"2026032708274036300_B1","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1093\/infdis\/161.4.618","article-title":"A new respiratory tract pathogen: Chlamydia pneumoniae strain TWAR.","volume":"161","author":"Grayston","year":"1990","journal-title":"J. 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