{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T15:09:28Z","timestamp":1791126568075,"version":"4.1.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2000,12,1]],"date-time":"2000-12-01T00:00:00Z","timestamp":975628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A cohort of 378 asthmatic children was studied from 7 to 35 yr of age at 7-yr intervals. On selection for inclusion in the study sample, the children had a wide range of severity of wheezing. At each 7-yr review, asthma severity, the presence of eczema or hay fever, and skin test reactivity to house dust mite or rye grass were recorded by questionnaire or clinical interview. We report on the course of asthma and these atopic conditions over the study period and discuss associations between the two phenomena. The presence of an atopic condition in childhood was found to increase the odds of more severe asthma in later life (odds ratio [OR] = 1.66, 95% confidence interval [CI]: 1.17 to 2.36 in the case of eczema; OR = 1.39, 95% CI: 1.00 to 1.92 for hay fever; and OR = 2.25, 95% CI: 1.49 to 3.39 for skin test reactivity). Additionally, the odds of eczema and hay fever in later life increased with severity of asthma in childhood. The findings of this study provide substantially new quantitative information on the extent of association between asthma and atopic conditions from childhood into middle adulthood.<\/jats:p>","DOI":"10.1164\/ajrccm.162.6.9812019","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T14:29:27Z","timestamp":1365085767000},"page":"2177-2181","source":"Crossref","is-referenced-by-count":61,"title":["Association Between Allergy and Asthma from Childhood to Middle Adulthood in an Australian Cohort Study"],"prefix":"10.1093","volume":"162","author":[{"given":"RORY","family":"WOLFE","sequence":"first","affiliation":[{"name":"Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute; Department of Respiratory Medicine, Royal Children's Hospital; and Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JOHN B.","family":"CARLIN","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute; Department of Respiratory Medicine, Royal Children's Hospital; and Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HELMUT","family":"OSWALD","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute; Department of Respiratory Medicine, Royal Children's Hospital; and Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANTHONY","family":"OLINSKY","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute; Department of Respiratory Medicine, Royal Children's Hospital; and Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PETER D.","family":"PHELAN","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute; Department of Respiratory Medicine, Royal Children's Hospital; and Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"COLIN F.","family":"ROBERTSON","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute; Department of Respiratory Medicine, Royal Children's Hospital; and Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,12,1]]},"reference":[{"key":"2026032708322051900_B1","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1136\/bmj.312.7040.1195","article-title":"Incidence and prognosis of asthma and wheezing illness from early childhood to age 33 in a national British cohort.","volume":"312","author":"Strachan","year":"1996","journal-title":"BMJ"},{"key":"2026032708322051900_B2","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1164\/ajrccm.149.1.8111567","article-title":"Outcome of wheeze in childhood (symptoms and pulmonary function 25 years later).","volume":"149","author":"Godden","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032708322051900_B3","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1183\/09031936.93.06050657","article-title":"The state of childhood asthma in young adulthood.","volume":"6","author":"Kokkonen","year":"1993","journal-title":"Eur Respir J"},{"key":"2026032708322051900_B4","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1164\/ajrccm\/140.5.1325","article-title":"Prognosis of asthma from childhood to adulthood.","volume":"140","author":"Gerritsen","year":"1989","journal-title":"Am Rev Respir Dis"},{"key":"2026032708322051900_B5","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1056\/NEJM199501193320301","article-title":"Asthma and wheezing in the first six years of life.","volume":"332","author":"Martinez","year":"1995","journal-title":"N Engl J Med"},{"key":"2026032708322051900_B6","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/0091-6749(90)90232-S","article-title":"Allergy in subjects with asthma to adult life.","volume":"85","author":"Gerritsen","year":"1990","journal-title":"J Allergy Clin Immunol"},{"key":"2026032708322051900_B7","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1136\/bmj.302.6785.1116","article-title":"Prevalence of asthma in Melbourne schoolchildren: changes over 26 years.","volume":"302","author":"Robertson","year":"1991","journal-title":"BMJ"},{"key":"2026032708322051900_B8","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1136\/bmj.4.5679.321","article-title":"Prevalence, natural history, and relationship of wheezy bronchitis and asthma in children: an epidemiological study.","volume":"4","author":"Williams","year":"1969","journal-title":"BMJ"},{"key":"2026032708322051900_B9","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1136\/bmj.4.5883.12","article-title":"Spectrum of asthma in children\u2014II: allergic components.","volume":"4","author":"McNicol","year":"1973","journal-title":"BMJ"},{"key":"2026032708322051900_B10","doi-asserted-by":"crossref","first-page":"470","DOI":"10.5694\/j.1326-5377.1981.tb112942.x","article-title":"Natural history of allergy in asthmatic children followed to adult life.","volume":"2","author":"Martin","year":"1981","journal-title":"Med J Aust"},{"key":"2026032708322051900_B11","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/0091-6749(90)90092-I","article-title":"Atopy in subjects with asthma followed to the age of 28 years.","volume":"85","author":"Kelly","year":"1990","journal-title":"J Allergy Clin Immunol"},{"key":"2026032708322051900_B12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1136\/bmj.309.6947.95","article-title":"Outcome of childhood asthma in mid-adult life.","volume":"309","author":"Oswald","year":"1994","journal-title":"BMJ"},{"key":"2026032708322051900_B13","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1136\/adc.45.244.789","article-title":"Chest deformity, residual airways obstruction and hyperinflation and growth in children with asthma: part II. 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