{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:30:15Z","timestamp":1790857815325,"version":"4.1.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2000,12,1]],"date-time":"2000-12-01T00:00:00Z","timestamp":975628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hyperoxia may contribute to lung disease in newborns through effects on alveolar neutrophils which predominate in respiratory distress syndrome and other acute lung injuries. Neutrophil chemokines such as interleukin-8 (IL-8) regulate chemoattraction, and are elevated in tracheal aspirates of newborns who develop bronchopulmonary dysplasia (BPD). Blockade of neutrophil chemokines may reduce hyperoxia-induced inflammatory lung injury and BPD. We therefore tested the hypothesis that hyperoxia contributes to elevations of rat neutrophil chemokines, cytokine- induced neutrophil chemoattractant-1 (CINC-1), and macrophage inflammatory protein-2 (MIP-2) in newborn rat lung. Newborn rats were exposed to air or 95% O2 for 8 d. CINC-1 and MIP-2 were measured in whole lung homogenates by ELISA. Newborn 95% O2\u2013exposed animals were given anti-CINC-1 or anti-MIP-2, 1, 5, or 10 \u03bc g on Days 3 and 4 of 95% O2 exposure. Bronchoalveolar lavage (BAL) was performed after perfusion on Day 6 to evaluate airway neutrophils, and myeloperoxidase (MPO) was measured in perfused whole lung. Lungs were examined histologically and immunohistochemically for effects of 95% O2 \u00b1 antichemokine. CINC-1 and MIP-2 increased nearly tenfold by Day 8 95% O2 treatment versus air control. CINC-1 and MIP-2 immunolabeling was increased in alveolar macrophages and alveolar epithelium in 95% O2. Anti-CINC-1 and anti-MIP-2 treatment at every dose reduced neutrophil number &amp;gt; 90% in BAL. Anti-CINC-1 10 \u03bc g reduced tissue MPO by 50%. Antichemokine treatment on Days 3 and 4 prevented alveolar septal thickening and reduced chemokine immunolabeling on Day 6. Hyperoxia-induced neutrophil influx is mediated in part by CINC-1 and MIP-2 in newborn rats and can be partially prevented by treatment with anti-CINC-1 and anti-MIP-2.<\/jats:p>","DOI":"10.1164\/ajrccm.162.6.9911020","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T14:29:27Z","timestamp":1365085767000},"page":"2316-2323","source":"Crossref","is-referenced-by-count":96,"title":["Lung Inflammation in Hyperoxia Can Be Prevented By Antichemokine Treatment in Newborn Rats"],"prefix":"10.1093","volume":"162","author":[{"given":"HUI","family":"DENG","sequence":"first","affiliation":[{"name":"Neonatal Perinatal Research Institute, Division of Neonatal Medicine, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"NICHOLAS MASON","sequence":"additional","affiliation":[{"name":"Neonatal Perinatal Research Institute, Division of Neonatal Medicine, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"RICHARD L.","family":"AUTEN","sequence":"additional","affiliation":[{"name":"Neonatal Perinatal Research Institute, Division of Neonatal Medicine, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,12,1]]},"reference":[{"key":"2026032708310629200_B1"},{"issue":"9","key":"2026032708310629200_B2","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1203\/00006450-198209000-00018","article-title":"Oxygen exposure in the newborn guinea pig lung lavage cell chemotactic and elastase response: a possible relationship to bronchopulmonary dysplasia.","volume":"16","author":"Merritt","year":"1982","journal-title":"Pediatr 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