{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T03:34:31Z","timestamp":1783049671891,"version":"3.54.6"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2001,7,1]],"date-time":"2001-07-01T00:00:00Z","timestamp":993945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study evaluated the prevalence of upper respiratory symptoms (URS) among patients with symptomatic gastroesophageal reflux disease (GERD). Seventy-four subjects with heartburn completed a URS questionnaire before dual-probe, 24-h esophageal pH monitoring. The URS questionnaire was also completed by 74 normal volunteers without previous or current symptoms of GERD. Esophageal pH monitoring results were classified as normal, distal, or proximal and distal gastroesophageal reflux using standardized criteria. Mean URS scores (\u00b1 SD) were 8.31 \u00b1 3.98 in the 52 subjects with GERD and 4.57 \u00b1 3.57 in the 22 subjects with negative pH probe studies, p = 0.02. Subjects with negative pH probe studies and normal volunteers scored similarly on the URS questionnaire. Reflux episodes\/24 h correlated with URS scores, r = 0.47, p = 0.0001. Seventy-five percent of subjects with upper reflux, 68% of subjects with lower reflux, 36% of subjects with normal esophageal pH studies, and 9% of normal volunteers reported laryngeal symptoms for at least 5 d\/mo. Sixty-nine percent of subjects with upper reflux, 50% of subjects with lower reflux, 31% of subjects with normal pH studies, and 14% of normal volunteers reported nasal symptoms for at least 5 d\/mo. URS are frequent among subjects with GERD.<\/jats:p>","DOI":"10.1164\/ajrccm.164.1.2006002","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T14:46:16Z","timestamp":1365086776000},"page":"72-76","source":"Crossref","is-referenced-by-count":53,"title":["Prevalence of Upper Respiratory Symptoms in Patients with Symptomatic Gastroesophageal Reflux Disease"],"prefix":"10.1093","volume":"164","author":[{"given":"DEMETRIOS S.","family":"THEODOROPOULOS","sequence":"first","affiliation":[{"name":"Division of Allergy and Immunology, Joy McCann Culverhouse Airways Disease Research Center and Joy McCann Culverhouse Center for Swallowing Disorders, Department of Internal Medicine, University of South Florida College of Medicine and James A. Haley Veterans' Medical Center, Tampa, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DENNIS K.","family":"LEDFORD","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Joy McCann Culverhouse Airways Disease Research Center and Joy McCann Culverhouse Center for Swallowing Disorders, Department of Internal Medicine, University of South Florida College of Medicine and James A. Haley Veterans' Medical Center, Tampa, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RICHARD F.","family":"LOCKEY","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Joy McCann Culverhouse Airways Disease Research Center and Joy McCann Culverhouse Center for Swallowing Disorders, Department of Internal Medicine, University of South Florida College of Medicine and James A. Haley Veterans' Medical Center, Tampa, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DONNA L.","family":"PECORARO","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Joy McCann Culverhouse Airways Disease Research Center and Joy McCann Culverhouse Center for Swallowing Disorders, Department of Internal Medicine, University of South Florida College of Medicine and James A. Haley Veterans' Medical Center, Tampa, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JOHN A.","family":"RODRIGUEZ","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Joy McCann Culverhouse Airways Disease Research Center and Joy McCann Culverhouse Center for Swallowing Disorders, Department of Internal Medicine, University of South Florida College of Medicine and James A. Haley Veterans' Medical Center, Tampa, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MILTON C.","family":"JOHNSON","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Joy McCann Culverhouse Airways Disease Research Center and Joy McCann Culverhouse Center for Swallowing Disorders, Department of Internal Medicine, University of South Florida College of Medicine and James A. Haley Veterans' Medical Center, Tampa, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"H. WORTH","family":"BOYCE","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Joy McCann Culverhouse Airways Disease Research Center and Joy McCann Culverhouse Center for Swallowing Disorders, Department of Internal Medicine, University of South Florida College of Medicine and James A. Haley Veterans' Medical Center, Tampa, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,7,1]]},"reference":[{"key":"2026032707581727400_B1"},{"key":"2026032707581727400_B2"},{"key":"2026032707581727400_B3"},{"key":"2026032707581727400_B4","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0165-5876(91)90079-Q","article-title":"Nasopharyngeal pH monitoring in infants and children with chronic rhinopharyngitis.","volume":"22","author":"Contencin","year":"1991","journal-title":"Int J Pediatr Otolaryngol"},{"key":"2026032707581727400_B5","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/j.1398-9995.1999.00093.x","article-title":"Gastroesophageal reflux and asthma: a review of pathogenesis, diagnosis and therapy.","volume":"54","author":"Theodoropoulos","year":"1999","journal-title":"Allergy"},{"key":"2026032707581727400_B6","first-page":"325","article-title":"Twenty-four-hour pH monitoring of the distal esophagus.","volume":"62","author":"Johnson","year":"1974","journal-title":"Am J Gastroenterol"},{"key":"2026032707581727400_B7"},{"key":"2026032707581727400_B8","first-page":"25","article-title":"Normal and abnormal proximal esophageal acid exposure: results of ambulatory dual-probe pH monitoring.","volume":"88","author":"Dobhan","year":"1993","journal-title":"Am J Gastroenterol"},{"key":"2026032707581727400_B9","first-page":"A123","article-title":"Upper respiratory symptoms in patients with gastroesophageal reflux.","volume":"159","author":"Theodoropoulos","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032707581727400_B10","first-page":"1102","article-title":"Ambulatory 24-hr esophageal pH monitoring: normal values, optimal thresholds, specificity, sensitivity, and reproducibility.","volume":"87","author":"Jamieson","year":"1992","journal-title":"Am J Gastroenterol"},{"key":"2026032707581727400_B11","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1001\/archsurg.134.8.882","article-title":"The pattern of esophageal acid exposure in gastroesophageal reflux disease influences the severity of the disease.","volume":"134","author":"Campos","year":"1999","journal-title":"Arch Surg"},{"key":"2026032707581727400_B12","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1136\/gut.37.1.7","article-title":"Lowered oesophageal sensory thresholds in patients with symptomatic but not excess gastro-oesophageal reflux: evidence for a spectrum of visceral sensitivity in GORD.","volume":"37","author":"Trimble","year":"1995","journal-title":"Gut"},{"key":"2026032707581727400_B13","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1378\/chest.115.3.848","article-title":"A critical review of the studies of the effects of simulated or real gastroesophageal reflux on pulmonary function in asthmatic adults.","volume":"115","author":"Field","year":"1999","journal-title":"Chest"},{"key":"2026032707581727400_B14","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1152\/jappl.1997.82.3.738","article-title":"Esophageal stimulation by hydrochloric acid causes neurogenic inflammation in the airways in guinea pigs.","volume":"82","author":"Hamamoto","year":"1997","journal-title":"J Appl Physiol"},{"key":"2026032707581727400_B15","doi-asserted-by":"crossref","first-page":"C138","DOI":"10.1152\/ajpcell.1994.267.1.C138","article-title":"Picomolar doses of substance P trigger electrical responses in mast cells without degranulation.","volume":"267","author":"Janiszewski","year":"1994","journal-title":"Am J Physiol"},{"key":"2026032707581727400_B16","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1046\/j.1365-2222.1999.00683.x","article-title":"Neuro-immune interactions in the lung.","volume":"29","author":"James","year":"1999","journal-title":"Clin Exp Allergy"},{"key":"2026032707581727400_B17"},{"key":"2026032707581727400_B18","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0022-3468(00)70013-3","article-title":"Reply to Crisera CA, Connelly PR, Marmureanu AR, et al. \u201cTTF-1 and HNF-3\u03b2 in the developing tracheoesophageal fistula: further evidence for the respiratory origin of the distal esophagus.\u201d","volume":"35","author":"Theodoropoulos","year":"1999","journal-title":"J Pediatr Surg"},{"key":"2026032707581727400_B19","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1001\/archinte.1995.00430200044008","article-title":"Guidelines for the diagnosis and treatment of gastroesophageal reflux disease: Practice Parameters Committee of the American College of Gastroenterology.","volume":"155","author":"DeVault","year":"1995","journal-title":"Arch. 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