{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T09:09:22Z","timestamp":1793956162820,"version":"4.8.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2001,8,1]],"date-time":"2001-08-01T00:00:00Z","timestamp":996624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We compared crural diaphragm electrical activity (EAdi) with transdiaphragmatic pressure (Pdi) during varying levels of pressure support ventilation (PS) in 13 intubated patients. With changing PS, we found no evidence for changes in neuromechanical coupling of the diaphragm. From lowest to highest PS (2 cm H2O \u00b1 4 to 20 cm H2O \u00b1 7), tidal volume increased from 430 ml \u00b1 180 to 527 ml \u00b1 180 (p &amp;lt; 0.001). The inspiratory volume calculated during the period when EAdi increased to its peak did not change from 276 \u00b1 147 to 277 \u00b1 162 ml, p = 0.976. Respiratory rate decreased from 23.9 (\u00b1 7) to 21.3 (\u00b1 7) breaths\/min (p = 0.015). EAdi and Pdi decreased proportionally by adding PS (r = 0.84 and r = 0.90, for mean and peak values, respectively). Mean and peak EAdi decreased (p &amp;lt; 0.001) by 33 \u00b1 21% (mean \u00b1 SD) and 37 \u00b1 23% with the addition of 10 cm H2O of PS, similar to the decrease in the mean and peak Pdi (p &amp;lt; 0.001) observed (34 \u00b1 36 and 35 \u00b1 23%). We also found that ventilator assist continued during the diaphragm deactivation period, a phenomenon that was further exaggerated at higher PS levels. We conclude that EAdi is a valid measurement of neural drive to the diaphragm in acute respiratory failure.<\/jats:p>","DOI":"10.1164\/ajrccm.164.3.2009018","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T14:49:24Z","timestamp":1365086964000},"page":"419-424","source":"Crossref","is-referenced-by-count":176,"title":["Electrical Activity of the Diaphragm during Pressure Support Ventilation in Acute Respiratory Failure"],"prefix":"10.1093","volume":"164","author":[{"given":"JENNIFER","family":"BECK","sequence":"first","affiliation":[{"name":"H\u00f4pital Ste-Justine, Department of Pediatrics and Department of Medicine, McGill University Health Centre; Meakins-Christie Laboratories, Division of Critical Care Medicine, Department of Medicine, and Centre de Recherche Guy-Bernier, Division of Intensive Care, H\u00f4pital Maisonneuve-Rosemont, Montreal, Quebec, Canada; Fondazione S. Maugeri, Pulmonary Rehabilitation and Respiratory Intensive Care, Pavia, and Bioingegneria, Ospedale Valduce, Costamasnaga, Italy; and Institution of Clinical Neuroscience, Sahlgrenska Hospital, University of G\u00f6teborg, G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"STEWART B.","family":"GOTTFRIED","sequence":"additional","affiliation":[{"name":"H\u00f4pital Ste-Justine, Department of Pediatrics and Department of Medicine, McGill University Health Centre; Meakins-Christie Laboratories, Division of Critical Care Medicine, Department of Medicine, and Centre de Recherche Guy-Bernier, Division of Intensive Care, H\u00f4pital Maisonneuve-Rosemont, Montreal, Quebec, Canada; Fondazione S. Maugeri, Pulmonary Rehabilitation and Respiratory Intensive Care, Pavia, and Bioingegneria, Ospedale Valduce, Costamasnaga, Italy; and Institution of Clinical Neuroscience, Sahlgrenska Hospital, University of G\u00f6teborg, G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PAOLO","family":"NAVALESI","sequence":"additional","affiliation":[{"name":"H\u00f4pital Ste-Justine, Department of Pediatrics and Department of Medicine, McGill University Health Centre; Meakins-Christie Laboratories, Division of Critical Care Medicine, Department of Medicine, and Centre de Recherche Guy-Bernier, Division of Intensive Care, H\u00f4pital Maisonneuve-Rosemont, Montreal, Quebec, Canada; Fondazione S. Maugeri, Pulmonary Rehabilitation and Respiratory Intensive Care, Pavia, and Bioingegneria, Ospedale Valduce, Costamasnaga, Italy; and Institution of Clinical Neuroscience, Sahlgrenska Hospital, University of G\u00f6teborg, G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YOANNA","family":"SKROBIK","sequence":"additional","affiliation":[{"name":"H\u00f4pital Ste-Justine, Department of Pediatrics and Department of Medicine, McGill University Health Centre; Meakins-Christie Laboratories, Division of Critical Care Medicine, Department of Medicine, and Centre de Recherche Guy-Bernier, Division of Intensive Care, H\u00f4pital Maisonneuve-Rosemont, Montreal, Quebec, Canada; Fondazione S. Maugeri, Pulmonary Rehabilitation and Respiratory Intensive Care, Pavia, and Bioingegneria, Ospedale Valduce, Costamasnaga, Italy; and Institution of Clinical Neuroscience, Sahlgrenska Hospital, University of G\u00f6teborg, G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NORMAN","family":"COMTOIS","sequence":"additional","affiliation":[{"name":"H\u00f4pital Ste-Justine, Department of Pediatrics and Department of Medicine, McGill University Health Centre; Meakins-Christie Laboratories, Division of Critical Care Medicine, Department of Medicine, and Centre de Recherche Guy-Bernier, Division of Intensive Care, H\u00f4pital Maisonneuve-Rosemont, Montreal, Quebec, Canada; Fondazione S. Maugeri, Pulmonary Rehabilitation and Respiratory Intensive Care, Pavia, and Bioingegneria, Ospedale Valduce, Costamasnaga, Italy; and Institution of Clinical Neuroscience, Sahlgrenska Hospital, University of G\u00f6teborg, G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MAURO","family":"ROSSINI","sequence":"additional","affiliation":[{"name":"H\u00f4pital Ste-Justine, Department of Pediatrics and Department of Medicine, McGill University Health Centre; Meakins-Christie Laboratories, Division of Critical Care Medicine, Department of Medicine, and Centre de Recherche Guy-Bernier, Division of Intensive Care, H\u00f4pital Maisonneuve-Rosemont, Montreal, Quebec, Canada; Fondazione S. Maugeri, Pulmonary Rehabilitation and Respiratory Intensive Care, Pavia, and Bioingegneria, Ospedale Valduce, Costamasnaga, Italy; and Institution of Clinical Neuroscience, Sahlgrenska Hospital, University of G\u00f6teborg, G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHRISTER","family":"SINDERBY","sequence":"additional","affiliation":[{"name":"H\u00f4pital Ste-Justine, Department of Pediatrics and Department of Medicine, McGill University Health Centre; Meakins-Christie Laboratories, Division of Critical Care Medicine, Department of Medicine, and Centre de Recherche Guy-Bernier, Division of Intensive Care, H\u00f4pital Maisonneuve-Rosemont, Montreal, Quebec, Canada; Fondazione S. Maugeri, Pulmonary Rehabilitation and Respiratory Intensive Care, Pavia, and Bioingegneria, Ospedale Valduce, Costamasnaga, Italy; and Institution of Clinical Neuroscience, Sahlgrenska Hospital, University of G\u00f6teborg, G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,8,1]]},"reference":[{"key":"2026032708041656500_B1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1152\/jappl.1966.21.2.527","article-title":"Nervous output from the respiratory centers during obstructed breathing.","volume":"21","author":"Lourenco","year":"1966","journal-title":"J Appl Physiol"},{"key":"2026032708041656500_B2","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1152\/jappl.1998.85.3.1123","article-title":"Effects of lung volume on diaphragm EMG signal strength during voluntary contractions.","volume":"85","author":"Beck","year":"1998","journal-title":"J Appl 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