{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T12:54:44Z","timestamp":1774616084286,"version":"3.50.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2001,8,1]],"date-time":"2001-08-01T00:00:00Z","timestamp":996624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Surfactant protein-B is a lung specific protein secreted into the air spaces by pulmonary epithelial type II cells that leaks into the bloodstream in increased amounts in patients with ARDS. To test whether elevated plasma levels of surfactant protein-B would predict the development of ARDS in patients with acute hypoxemic respiratory failure, plasma and lung injury scores were collected at study entry and daily thereafter for 3 d from 54 patients admitted to our intensive care unit. ARDS was defined as a new bilateral infiltrate on chest radiograph and a lung injury score \u2a7e 2.5. Twenty patients developed ARDS, of whom seven died. Although the initial lung injury score was not predictive of ARDS, the initial plasma surfactant protein-B was predictive (area under the curve = 0.77 [0.63 to 0.90], nonparametric receiver-operating characteristic analysis). In this cohort, plasma surfactant protein-B was particularly predictive of ARDS when applied to patients suffering a direct lung insult (area under the curve = 0.87 [0.72 to 1.02]), with a sensitivity of 85% (95% CI: 55 to 98%) and specificity of 78% (40 to 97%) at a cutoff of 4,994 ng\/ml.<\/jats:p>","DOI":"10.1164\/ajrccm.164.4.2010111","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T14:49:35Z","timestamp":1365086975000},"page":"648-652","source":"Crossref","is-referenced-by-count":53,"title":["Elevated Plasma Surfactant Protein-B Predicts Development of Acute Respiratory Distress Syndrome in Patients with Acute Respiratory Failure"],"prefix":"10.1093","volume":"164","author":[{"given":"ANDREW D.","family":"BERSTEN","sequence":"first","affiliation":[{"name":"Departments of Critical Care Medicine and Human Physiology, Flinders Medical Centre and School of Medicine, Flinders University, South Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TAMARA","family":"HUNT","sequence":"additional","affiliation":[{"name":"Departments of Critical Care Medicine and Human Physiology, Flinders Medical Centre and School of Medicine, Flinders University, South Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TERRENCE E.","family":"NICHOLAS","sequence":"additional","affiliation":[{"name":"Departments of Critical Care Medicine and Human Physiology, Flinders Medical Centre and School of Medicine, Flinders University, South Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"IAN R.","family":"DOYLE","sequence":"additional","affiliation":[{"name":"Departments of Critical Care Medicine and Human Physiology, Flinders Medical Centre and School of Medicine, Flinders University, South Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2001,8,15]]},"reference":[{"key":"2026032708013770800_B1","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1056\/NEJM200005043421806","article-title":"The acute respiratory distress syndrome.","volume":"342","author":"Ware","year":"2000","journal-title":"N Engl J Med"},{"key":"2026032708013770800_B2","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1164\/ajrccm\/142.6_Pt_1.1250","article-title":"Intact epithelial barrier function is critical for the resolution of alveolar edema in humans.","volume":"142","author":"Matthay","year":"1990","journal-title":"Am Rev Respir Dis"},{"key":"2026032708013770800_B3","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1046\/j.1440-1681.1999.03015.x","article-title":"Partitioning lung and plasma proteins: circulating surfactant proteins as biomarkers of alveolocapillary permeability.","volume":"26","author":"Doyle","year":"1999","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"2026032708013770800_B4","first-page":"718","article-title":"The spectrum of pulmonary edema: differentiation of cardiogenic, intermediate, and noncardiogenic forms of pulmonary edema.","volume":"124","author":"Sprung","year":"1981","journal-title":"Am Rev Respir Dis"},{"key":"2026032708013770800_B5","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1164\/ajrccm.152.1.7599839","article-title":"Serum surfactant protein-A levels in patients with acute cardiogenic pulmonary edema and adult respiratory distress syndrome.","volume":"152","author":"Doyle","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032708013770800_B6","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1164\/ajrccm.156.4.9603061","article-title":"Surfactant proteins-A and -B are elevated in plasma of patients with acute respiratory failure.","volume":"156","author":"Doyle","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032708013770800_B7","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1378\/chest.116.suppl_1.90S","article-title":"Serum surfactant protein-A levels predict development of ARDS in at-risk patients.","volume":"116","author":"Greene","year":"1999","journal-title":"Chest"},{"key":"2026032708013770800_B8","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1164\/ajrccm.160.6.9901117","article-title":"Serial changes in surfactant-associated proteins in lung and serum before and after onset of ARDS.","volume":"160","author":"Greene","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032708013770800_B9","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1164\/ajrccm.155.4.9105054","article-title":"Biological markers of acute lung injury: prognostic and pathogenetic significance.","volume":"155","author":"Pittet","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032708013770800_B10","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1164\/ajrccm\/138.3.720","article-title":"An expanded definition of the adult respiratory distress syndrome.","volume":"138","author":"Murray","year":"1988","journal-title":"Am Rev Respir Dis"},{"key":"2026032708013770800_B11","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1172\/JCI115523","article-title":"Surfactant chemical composition and biophysical acivity in acute respiratory failure.","volume":"88","author":"Gregory","year":"1991","journal-title":"J Clin Invest"},{"key":"2026032708013770800_B12","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1164\/ajrccm\/147.3.723","article-title":"Tsutahara S, Shijubo N, Takahashi H, Shiratori M, Hattori A, Honda Y, Abe \u2009S, Akino T. Elevated levels of lung surfactant protein A in sera from patients with idiopathic pulmonary fibrosis and pulmonary alveolar proteinosis.","volume":"147","author":"Kuroki","year":"1993","journal-title":"Am Rev Respir Dis"},{"key":"2026032708013770800_B13","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0169-2607(93)90004-5","article-title":"A computer program for non-parametric receiver operating characteristic analysis.","volume":"40","author":"Visa","year":"1993","journal-title":"Comput Methods Programs Biomed"},{"key":"2026032708013770800_B14","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1164\/ajrccm.149.3.7509706","article-title":"The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination.","volume":"149","author":"Bernard","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032708013770800_B15","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1164\/ajrccm.157.4.ats2-98","article-title":"The American-European Consensus Conference on ARDS, part 2: ventilatory, pharmacologic, supportive therapy, study design strategies, and issues related to recovery and remodeling. Acute respiratory distress syndrome.","volume":"157","author":"Artigas","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032708013770800_B16","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1056\/NEJM199802053380602","article-title":"Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome.","volume":"338","author":"Amato","year":"1998","journal-title":"N Engl J Med"},{"key":"2026032708013770800_B17","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1164\/ajrccm.158.6.9801044","article-title":"Tidal volume reduction for prevention of ventricular-induced lung injury in acute respiratory distress syndrome.","volume":"158","author":"Brochard","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032708013770800_B18"},{"key":"2026032708013770800_B19","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1164\/ajrccm.163.2.2006067","article-title":"Agreement between alternative classifications of acute respiratory distress syndrome.","volume":"163","author":"Meade","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032708013770800_B20","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1097\/00003246-199510000-00006","article-title":"Establishing the relative accuracy of three new definitions of the adult respiratory distress syndrome.","volume":"23","author":"Moss","year":"1995","journal-title":"Crit Care Med"},{"key":"2026032708013770800_B21","doi-asserted-by":"crossref","first-page":"593","DOI":"10.7326\/0003-4819-98-5-593","article-title":"Adult respiratory distress syndrome: risk with common predispositions.","volume":"98","author":"Fowler","year":"1983","journal-title":"Ann Intern Med"},{"key":"2026032708013770800_B22","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1164\/ajrccm.151.2.7842182","article-title":"Clinical risks for development of the acute respiratory distress syndrome.","volume":"151","author":"Hudson","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032708013770800_B23","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1164\/ajrccm.159.5.9809027","article-title":"Initial serum ferritin levels in patients with multiple trauma and the subsequent development of acute respiratory distress syndrome.","volume":"159","author":"Sharkey","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032708013770800_B24","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1164\/ajrccm.155.1.9001283","article-title":"Serum ferritin as a predictor of the acute respiratory distress syndrome.","volume":"155","author":"Connelly","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032708013770800_B25","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1164\/ajrccm.158.1.9708031","article-title":"Acute respiratory distress syndrome caused by pulmonary and extrapulmonary disease: different syndromes?","volume":"158","author":"Gattinoni","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032708013770800_B26","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/00003246-200001000-00039","article-title":"Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: time for a reevaluation.","volume":"28","author":"Abraham","year":"2000","journal-title":"Crit Care Med"},{"key":"2026032708013770800_B27","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1164\/ajrccm.158.5.9712097","article-title":"Clearance of Clara cell secretory protein (CC16) and surfactant proteins A and B from the circulation of acute respiratory failure patients.","volume":"158","author":"Doyle","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032708013770800_B28","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0140-6736(94)92995-5","article-title":"Role of selectins in development of adult respiratory distress syndrome.","volume":"344","author":"Donnelly","year":"1994","journal-title":"Lancet"},{"key":"2026032708013770800_B29","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1164\/ajrccm.155.4.9105096","article-title":"Circulating IL-ra and IL-10 levels are increased but do not predict the development of acute respiratory distress syndrome in at-risk patients.","volume":"155","author":"Parsons","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"2026032708013770800_B30","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1172\/JCI114733","article-title":"Elevated von Willebrand factor antigen is an early plasma predictor of acute lung injury in nonpulmonary sepsis syndrome.","volume":"86","author":"Rubin","year":"1990","journal-title":"J Clin Invest"},{"key":"2026032708013770800_B31","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1164\/ajrccm.151.1.7812545","article-title":"von Willebrand factor antigen levels are not predictive for the adult respiratory distress syndrome.","volume":"151","author":"Moss","year":"1995","journal-title":"Am J Respir Crit Care Med"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/164\/4\/648\/67561755\/ajrccm_164_4_648.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/164\/4\/648\/67561755\/ajrccm_164_4_648.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T12:01:47Z","timestamp":1774612907000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/164\/4\/648\/8543795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8]]},"references-count":31,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2001,8,15]]},"published-print":{"date-parts":[[2001,8,15]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm.164.4.2010111","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2001,8]]},"published":{"date-parts":[[2001,8]]}}}