{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T12:54:55Z","timestamp":1774616095588,"version":"3.50.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2001,8,1]],"date-time":"2001-08-01T00:00:00Z","timestamp":996624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>It has recently been shown that CD4+ CD25+ T cells are immunoregulatory T cells that prevent CD4+ T cell-mediated organ-specific autoimmune diseases. To determine whether CD4+ CD25+ T cells downregulate Th2 cell-mediated allergic inflammation in the airways, we studied antigen-induced eosinophil recruitment in the airways in BALB\/c Rag-2\u2212\/\u2212 mice transferred with CD4+ CD25+ T cell-depleted or unfractionated T cells from ovalbumin-specific TCR transgenic mice. Antigen-induced eosinophil recruitment into the airways was significantly decreased in the mice transferred with CD4+ CD25+ T cell-depleted splenocytes as compared with those transferred with unfractionated splenocytes. On the other hand, the depletion of CD4+ CD25+ T cells increased antigen-induced neutrophil and T cell recruitment in the airways of the mice. The depletion of CD4+ CD25+ T cells also decreased antigen-induced IL-4 and IL-5 production in the airways of the mice. Finally, the depletion of CD4+ CD25+ T cells prevented antigen-induced Th2 cell differentiation in vitro but increased the differentiation of Th1 cells. These results indicate that CD4+ CD25+ T cells modulate the Th1 and Th2 cell balance toward Th2 cells and thus upregulate Th2 cell-mediated allergic inflammation in the airways.<\/jats:p>","DOI":"10.1164\/ajrccm.164.4.2010170","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T14:49:35Z","timestamp":1365086975000},"page":"680-687","source":"Crossref","is-referenced-by-count":82,"title":["Role of CD4+ CD25+ Regulatory T Cells in T Helper 2 Cell-mediated Allergic Inflammation in the Airways"],"prefix":"10.1093","volume":"164","author":[{"given":"AKIRA","family":"SUTO","sequence":"first","affiliation":[{"name":"Department of Internal Medicine II, Chiba University School of Medicine, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HIROSHI","family":"NAKAJIMA","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Chiba University School of Medicine, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHIN-ICHIRO","family":"KAGAMI","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Chiba University School of Medicine, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KOTARO","family":"SUZUKI","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Chiba University School of Medicine, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YASUSHI","family":"SAITO","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Chiba University School of Medicine, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ITSUO","family":"IWAMOTO","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Chiba University School of Medicine, Chiba, 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