{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T09:54:37Z","timestamp":1775210077389,"version":"3.50.1"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2001,8,1]],"date-time":"2001-08-01T00:00:00Z","timestamp":996624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mediastinal fibrosis is a rare consequence of infection with the fungus Histoplasma capsulatum that can lead to occlusion of large pulmonary arteries and veins and mainstem bronchi. Medical and surgical treatments for this disorder have been ineffective. We describe successful treatment for central pulmonary arterial and venous obstruction due to mediastinal fibrosis in four patients using percutaneously placed intravascular stents. Patients were severely limited, World Health Organization functional class III or IV. At the time of right and left heart catheterization, stents were placed in pulmonary arteries (n = 1), veins (n = 2), or both (n = 1) to relieve vascular obstruction resulting from mediastinal fibrosis. Immediate hemodynamic and clinical improvement was observed in all patients. Three of the four patients have had sustained improvement in exercise tolerance, from 3.5 mo to 4.5 yr after stent placement. The only complication was a self-limited pulmonary hemorrhage in one patient. Our initial experience suggests that percutaneous stent placement to relieve central pulmonary arterial or venous obstruction due to mediastinal fibrosis is an effective new treatment modality.<\/jats:p>","DOI":"10.1164\/ajrccm.164.4.2012132","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T14:49:35Z","timestamp":1365086975000},"page":"657-660","source":"Crossref","is-referenced-by-count":80,"title":["Percutaneous Pulmonary Artery and Vein Stenting"],"prefix":"10.1093","volume":"164","author":[{"given":"THOMAS P.","family":"DOYLE","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology and Center for Lung Research, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAMES E.","family":"LOYD","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology and Center for Lung Research, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"IVAN M.","family":"ROBBINS","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology and Center for Lung Research, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2001,8,15]]},"reference":[{"key":"2026032708020420300_B1"},{"key":"2026032708020420300_B2"},{"key":"2026032708020420300_B3","first-page":"213","article-title":"Histoplasmosis with symptomatic lymphadenopathy.","volume":"77","author":"Goodwin","year":"1981","journal-title":"Chest"},{"key":"2026032708020420300_B4"},{"key":"2026032708020420300_B5","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1378\/chest.89.2.296","article-title":"Pulmonary vascular occlusion and fibrosing mediastinitis.","volume":"89","author":"Berry","year":"1986","journal-title":"Chest"},{"key":"2026032708020420300_B6","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1136\/thx.41.3.210","article-title":"Saunders NR. Maher O. Lennox SC. Walker DR. Surgical treatment of idiopathic mediastinal fibrosis: report of five cases.","volume":"41","author":"Mitchell","year":"1986","journal-title":"Thorax"},{"key":"2026032708020420300_B7","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/0002-9149(67)90016-1","article-title":"Clinical and hemodynamic diagnosis of pulmonary venous obstruction due to sclerosing mediastinitis.","volume":"20","author":"Nassar","year":"1967","journal-title":"Am J Cardiol"},{"key":"2026032708020420300_B8","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0003-4975(10)66588-5","article-title":"Progressive fibrosing mediastinitis.","volume":"3","author":"Hewlett","year":"1966","journal-title":"Ann Thorac Surg"},{"key":"2026032708020420300_B9","first-page":"227","article-title":"Idiopathic mediastinal fibrosis and retroperitoneal fibrosis.","volume":"85","author":"Cameron","year":"1961","journal-title":"Can Med Assoc J"},{"key":"2026032708020420300_B10","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1161\/01.CIR.83.6.1923","article-title":"Use of endovascular stents in congenital heart disease.","volume":"83","author":"O'Laughlin","year":"1991","journal-title":"Circulation"},{"key":"2026032708020420300_B11","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1161\/01.CIR.88.2.605","article-title":"Implantation and intermediate-term follow-up of stents in congenital heart disease.","volume":"88","author":"O'Laughlin","year":"1993","journal-title":"Circulation"},{"key":"2026032708020420300_B12","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0735-1097(97)00535-4","article-title":"Intravascular stents in congenital heart disease: short-and long-term results from a large single-center experience.","volume":"31","author":"Shaffer","year":"1998","journal-title":"J Am Coll Cardiol"},{"key":"2026032708020420300_B13"},{"key":"2026032708020420300_B14","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/(SICI)1522-726X(200003)49:3<321::AID-CCD20>3.0.CO;2-5","article-title":"Percutaneous stenting of right pulmonary artery stenosis in fibrosing mediastinitis.","volume":"49","author":"Kandzari","year":"2000","journal-title":"Cardiovasc Intervent"},{"key":"2026032708020420300_B15","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1378\/chest.119.3.966","article-title":"Treatment of pulmonary artery compression due to fibrous mediastinitis with endovascular stent placement.","volume":"119","author":"Guerrero","year":"2001","journal-title":"Chest"},{"key":"2026032708020420300_B16","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/S0022-5223(95)70075-7","article-title":"Experience with repair of congenital heart defects using adjunctive endovascular devices.","volume":"110","author":"Coles","year":"1995","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2026032708020420300_B17","first-page":"210","article-title":"Intraoperative and percutaneous stenting of congenital pulmonary artery and vein stenosis.","volume":"88","author":"Mendelsohn","year":"1993","journal-title":"Circulation"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/164\/4\/657\/67562199\/ajrccm_164_4_657.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/164\/4\/657\/67562199\/ajrccm_164_4_657.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T12:02:08Z","timestamp":1774612928000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/164\/4\/657\/8543814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8]]},"references-count":17,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2001,8,15]]},"published-print":{"date-parts":[[2001,8,15]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm.164.4.2012132","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2001,8]]},"published":{"date-parts":[[2001,8]]}}}