{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T16:59:59Z","timestamp":1776185999684,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[1980,11,1]],"date-time":"1980-11-01T00:00:00Z","timestamp":341884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1980,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In a study of early-life risk factors for the development of adult obstructive airway disease, respiratory symptoms, disease and smoking histories, and spirometry were obtained for 650 children 5 to 9 yr of age and their families in East Boston, Massachusetts. Persistent wheezing was the most frequently reported chronic symptom, occurring in 9.2% (60\/650) of the population. Children with persistent wheezing were more likely to report cough and phlegm (p &amp;lt; 0.001), a history of asthma (p &amp;lt; 0.001), hay fever (p &amp;lt; 0.02), or past hospitalization with a respiratory illness (p &amp;lt; 0.001) than their asymptomatic peers. Prospective evaluation of a subsample of the 650 children confirmed a greater occurrence of acute lower respiratory illness in those children with persistent wheeze.<\/jats:p>\n                  <jats:p>Parental cigarette smoking was linearly related to the occurrence of persistent wheeze (p = 0.012) and lower degrees of mean normalized forced expiratory flow during the middle half of the forced vital capacity (FEF-Z score). A multiple linear regression identified the mother's current smoking status and current persistent wheeze as significant predictors of the children's mean FEF-Z score. Other variables, such as the father's smoking, children's personal smoking, a doctor's diagnosis of asthma, and a past history of lower respiratory illness were not significant predictors of the FEF-Z score.<\/jats:p>","DOI":"10.1164\/arrd.1980.122.5.697","type":"journal-article","created":{"date-parts":[[2015,10,22]],"date-time":"2015-10-22T10:30:45Z","timestamp":1445509845000},"page":"697-707","source":"Crossref","is-referenced-by-count":139,"title":["Persistent Wheeze"],"prefix":"10.1093","volume":"122","author":[{"given":"Scott T.","family":"Weiss","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ira B.","family":"Tager","sequence":"additional","affiliation":[{"name":"Dr. Tager is a recipient of an Edward Livingston Trudeau Fellowship from the American Lung Association"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank E.","family":"Speizer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Rosner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1980,11,1]]},"container-title":["American Review of Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/122\/5\/697\/67678396\/ajrccm_122_5_697.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/122\/5\/697\/67678396\/ajrccm_122_5_697.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T05:46:15Z","timestamp":1774935975000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/122\/5\/697\/8565269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1980,11,1]]},"published-print":{"date-parts":[[1980,11,1]]}},"URL":"https:\/\/doi.org\/10.1164\/arrd.1980.122.5.697","relation":{},"ISSN":["0003-0805"],"issn-type":[{"value":"0003-0805","type":"print"}],"subject":[],"published-other":{"date-parts":[[1980,11]]},"published":{"date-parts":[[1980,11,1]]}}}