{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T06:38:53Z","timestamp":1774939133270,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[1983,7,1]],"date-time":"1983-07-01T00:00:00Z","timestamp":425865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1983,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>An update of histopathologic classification schemes is provided for carcinoma of the lung and factors that influence proportional distributions of cell types, i.e., sources and preparations of tissue specimens, observer variability, and use of secondary sources of information. Consideration is given to the natural history and to current knowledge of the demographic characteristics of cell types of carcinoma of the lung. A review of studies reporting histopathologic associations with environmental exposures suggests that no single type of carcinoma of the lung is specifically associated with exposure to tobacco smoke, arsenic, or beryllium. Furthermore, studies concerned with exposure to asbestos, chloroethers, chromates, nickel, vinyl chloride, and radioactivity lack sufficient information to conclude definitively that only one specific lung cancer cell type is associated with these exposures. In conclusion, an exclusive association of a single cell type of carcinoma of the lung with exposure to the physical or chemical agents reviewed has not been demonstrated.<\/jats:p>","DOI":"10.1164\/arrd.1983.128.1.195","type":"journal-article","created":{"date-parts":[[2015,10,4]],"date-time":"2015-10-04T22:51:18Z","timestamp":1443999078000},"page":"195-209","source":"Crossref","is-referenced-by-count":68,"title":["Environmental Associations and Histopathologic Patterns of Carcinoma of the Lung: The Challenge and Dilemma in Epidemiologic Studies"],"prefix":"10.1093","volume":"128","author":[{"given":"Janet C.","family":"Ives","sequence":"first","affiliation":[{"name":"The writers are indebted to the reviewers who contributed substantially to the critical review and synthesis of the extensive pathology, epidemiology, and occupational medicine literature related to the topic. In the area of pathology, Drs. P. Kotin, M. Kuschner, G. Saccomanno, and R. Yesner provided invaluable suggestions and critical comments. Review and discussions with Drs. D. T. Carr, M. M. Key, and J. Samet were particularly valuable with regard to occupational exposures, occupational and pulmonary medicine, and the relevance of this review. We are equally indebted to our colleagues in epidemiology, Drs. A. H. Holguin, F. E. Lundin, Jr., L. W. Pickle, B. J. Selwyn, R. A. Stallones, and Ms. S. M. Wood for their thoughtful and incisive comments"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia A.","family":"Buffler","sequence":"additional","affiliation":[{"name":"Requests for reprints should be addressed to Dr. Patricia A. Buffler, The University of Texas Health Science Center at Houston, School of Public Health, P.O. Box 20186, Houston TX 77025"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Donald","family":"Greenberg","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at Houston School of Public Health"},{"name":"Baylor College of Medicine Department of Pathology \u00a0 Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1983,7,1]]},"container-title":["American Review of Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/128\/1\/195\/67670650\/ajrccm_128_1_195.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/128\/1\/195\/67670650\/ajrccm_128_1_195.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T05:10:14Z","timestamp":1774933814000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/128\/1\/195\/8562855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1983,7,1]]},"published-print":{"date-parts":[[1983,7,1]]}},"URL":"https:\/\/doi.org\/10.1164\/arrd.1983.128.1.195","relation":{},"ISSN":["0003-0805"],"issn-type":[{"value":"0003-0805","type":"print"}],"subject":[],"published-other":{"date-parts":[[1983,7]]},"published":{"date-parts":[[1983,7,1]]}}}