{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T06:24:20Z","timestamp":1774938260923,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[1986,11,1]],"date-time":"1986-11-01T00:00:00Z","timestamp":531187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1986,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We studied the contribution of neural influences, in particular, the nonadrenergic, non-cholinergic inhibitory system, on the modulation of airway responses to serotonin (5\u2212HT) in the anesthetized and mechanically ventilated cat. Airway responses were assessed by measurement of pulmonary resistance (RL). Parasympathectomy (PS) caused a variable increase in bronchoconstriction in 9 of 10 cats (n=10) that had received pretreatment intravenously with atropine (3 mg\/kg) and propranolol (2 mg\/kg); PS performed following pretreatment with phentolamine (2 mg\/kg), propranolol, and atropine led to an increase in bronchoconstriction in only 2 of 6 cats. Dose-response curves to aerosolized 5\u2212HT were performed in one group of cats (n=5) before and 30 min after PS and in control group (n=6). Both groups of animals were pretreated intravenously with atropine, propranolol, and phentolamine. The concentration of aerosolized 5\u2212HT that was necessary to double pulmonary resistance (ED200RL) was significantly reduced from 0.117 to 0.062 mg\/ml (p &amp;lt; 0.01) by PS, in contrast to control cats in which ED200RL during 2 consecutive dose-response curves (0.076 and 0.087 mg\/ml, respectively) did not change significantly. We conclude that there is neural modulation of airway responses to infused 5\u2212HT through an alpha-adrenergic pathway and that an additional inhibitory nonadrenergic, noncholinergic neural influence is demonstrable in the response to aerosolized 5\u2212HT.<\/jats:p>","DOI":"10.1164\/arrd.1986.133.1.110","type":"journal-article","created":{"date-parts":[[2015,11,7]],"date-time":"2015-11-07T14:32:26Z","timestamp":1446906746000},"page":"110-115","source":"Crossref","is-referenced-by-count":5,"title":["The Effects of Parasympathectomy on Serotonin-Induced Bronchoconstriction in the Cat"],"prefix":"10.1093","volume":"133","author":[{"given":"Tony R.","family":"Bai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter T.","family":"Macklem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James G.","family":"Martin","sequence":"additional","affiliation":[{"name":"Scholar of the Medical Research Council of Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1986,11,1]]},"container-title":["American Review of Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/133\/1\/110\/67667458\/ajrccm_133_1_110.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/133\/1\/110\/67667458\/ajrccm_133_1_110.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T04:56:10Z","timestamp":1774932970000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/133\/1\/110\/8561866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,11,1]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1986,11,1]]},"published-print":{"date-parts":[[1986,11,1]]}},"URL":"https:\/\/doi.org\/10.1164\/arrd.1986.133.1.110","relation":{},"ISSN":["0003-0805"],"issn-type":[{"value":"0003-0805","type":"print"}],"subject":[],"published-other":{"date-parts":[[1986,11]]},"published":{"date-parts":[[1986,11,1]]}}}