{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:45:36Z","timestamp":1791117936726,"version":"4.1.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2003,6,1]],"date-time":"2003-06-01T00:00:00Z","timestamp":1054425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Antagonizing the effect of interleukin (IL)-5 is a potential new treatment strategy in allergic disorders. We evaluated the safety, biological activity, and pharmacokinetics of SCH55700, a humanized anti-human IL-5 antibody, in subjects with severe persistent asthma treated with oral or high doses of inhaled steroids. In a double-blind, randomized, multicenter trial, a rising single dose of SCH55700 (0.03 mg\/kg [n = 2], 0.1 mg\/kg [n = 4], 0.3 mg\/kg [n = 6], or 1.0 mg\/kg [n = 12]) or placebo (n = 8) was administered intravenously. SCH55700 dose dependently reduced circulating eosinophil counts. At a dose of 1.0 mg\/kg, the decrease remained significant up to Day 30 [(0.07 \u00b1 0.01) \u00d7 109\/L versus (0.23 \u00b1 0.04) \u00d7 109\/L at baseline] (mean \u00b1 SEM) (p = 0.05). After administration of SCH55700 at 0.3 and 1.0 mg\/kg, a trend toward improvement in baseline FEV1 was observed, which reached significance 24 hours after the 0.3-mg\/kg dose (p = 0.019 versus placebo). No significant changes occurred in other clinical indices of disease activity. Adverse events were not different between active treatment and placebo. We conclude that SCH55700 is a biologically active anti-human IL-5 antibody that can be safely used in severe steroid-treated asthma. Its therapeutic potential needs to be addressed in specifically designed efficacy trials.<\/jats:p>","DOI":"10.1164\/rccm.200206-525oc","type":"journal-article","created":{"date-parts":[[2003,3,24]],"date-time":"2003-03-24T20:53:17Z","timestamp":1048539197000},"page":"1655-1659","source":"Crossref","is-referenced-by-count":395,"title":["Effect of SCH55700, a Humanized Anti-Human Interleukin-5 Antibody, in Severe Persistent Asthma: A Pilot Study"],"prefix":"10.1093","volume":"167","author":[{"given":"Johan C.","family":"Kips","sequence":"first","affiliation":[{"name":"Ghent University Hospital, Ghent, Belgium; Guy's, King's, and St Thomas's School of Medicine, London; Medicines Evaluation Unit, North West Lung Centre, Manchester, United Kingdom; University Hospital Groningen, Groningen, The Netherlands; and Schering-Plough Research Institute, Kenilworth, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"O'Connor","sequence":"additional","affiliation":[{"name":"Ghent University Hospital, Ghent, Belgium; Guy's, King's, and St Thomas's School of Medicine, London; Medicines Evaluation Unit, North West Lung Centre, Manchester, United Kingdom; University Hospital Groningen, Groningen, The Netherlands; and Schering-Plough Research Institute, Kenilworth, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Langley","sequence":"additional","affiliation":[{"name":"Ghent University Hospital, Ghent, Belgium; Guy's, King's, and St Thomas's School of Medicine, London; Medicines Evaluation Unit, North West Lung Centre, Manchester, United Kingdom; University Hospital Groningen, Groningen, The Netherlands; and Schering-Plough Research Institute, Kenilworth, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Woodcock","sequence":"additional","affiliation":[{"name":"Ghent University Hospital, Ghent, Belgium; Guy's, King's, and St Thomas's School of Medicine, London; Medicines Evaluation Unit, North West Lung Centre, Manchester, United Kingdom; University Hospital Groningen, Groningen, The Netherlands; and Schering-Plough Research Institute, Kenilworth, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huib A. M.","family":"Kerstjens","sequence":"additional","affiliation":[{"name":"Ghent University Hospital, Ghent, Belgium; Guy's, King's, and St Thomas's School of Medicine, London; Medicines Evaluation Unit, North West Lung Centre, Manchester, United Kingdom; University Hospital Groningen, Groningen, The Netherlands; and Schering-Plough Research Institute, Kenilworth, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirkje S.","family":"Postma","sequence":"additional","affiliation":[{"name":"Ghent University Hospital, Ghent, Belgium; Guy's, King's, and St Thomas's School of Medicine, London; Medicines Evaluation Unit, North West Lung Centre, Manchester, United Kingdom; University Hospital Groningen, Groningen, The Netherlands; and Schering-Plough Research Institute, Kenilworth, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mel","family":"Danzig","sequence":"additional","affiliation":[{"name":"Ghent University Hospital, Ghent, Belgium; 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