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Histamine levels of the airways in L-histidine decarboxylase knockout mice were largely diminished compared with wild-type mice. Inhalation challenge with ovalbumin (OVA) in OVA-sensitized wild-type mice caused eosinophil accumulation in the lung as well as airway hyperresponsiveness to methacholine 3 days after the challenge. The eosinophil recruitment was significantly reduced in the knockout mice. In the bone marrow, the proliferation of eosinophils was enhanced after OVA challenge in the wild-type mice; however, the proliferation was significantly reduced in the knockout mice. The induction of P-selectin in the lung after OVA challenge was also inhibited in the knockout mice. In contrast, airway hyperresponsiveness was not suppressed in the knockout mice. These results suggest that endogenous histamine is involved in the accumulation of eosinophils into the airways after allergic challenge, possibly acting in the bone marrow and producing P-selectin in the airways. Furthermore, allergen-induced airway hyperresponsiveness appeared to occur independently of airway eosinophilia in our present model.<\/jats:p>","DOI":"10.1164\/rccm.200206-619oc","type":"journal-article","created":{"date-parts":[[2003,2,21]],"date-time":"2003-02-21T16:51:52Z","timestamp":1045846312000},"page":"758-763","source":"Crossref","is-referenced-by-count":35,"title":["Disruption of L-Histidine Decarboxylase Reduces Airway Eosinophilia but not Hyperresponsiveness"],"prefix":"10.1093","volume":"167","author":[{"given":"Akira","family":"Koarai","sequence":"first","affiliation":[{"name":"Division of Respiratory and Infectious Diseases and Department of Cellular Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakazu","family":"Ichinose","sequence":"additional","affiliation":[{"name":"Division of Respiratory and Infectious Diseases and Department of Cellular Pharmacology, Tohoku University 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