{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T23:11:01Z","timestamp":1774566661013,"version":"3.50.1"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2003,2,1]],"date-time":"2003-02-01T00:00:00Z","timestamp":1044057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Infants often develop reactive airway disease after respiratory syncytial virus (RSV) bronchiolitis. Cysteinyl-leukotrienes (cys-LT) are released during RSV infection and may contribute to the inflammation. We hypothesized that a cys-LT receptor antagonist would ameliorate reactive airway disease subsequent to RSV bronchiolitis. One hundred and thirty infants who were 3 to 36 months old, hospitalized with acute RSV bronchiolitis, were randomized into a double-blind, parallel comparison of 5-mg montelukast chewable tablets or matching placebo given for 28 days starting within 7 days of symptom debut. Infants with a suspected history of asthma were excluded. One hundred sixteen infants provided diary card data for the treatment period. Median age was 9 months. Infants on montelukast were free of any symptoms on 22% of the days and nights compared with 4% of the days and nights in infants on placebo (p = 0.015). Daytime cough was significantly reduced on active treatment (p = 0.04). Exacerbations were significantly delayed from montelukast compared with placebo (p &amp;lt; 0.05). In conclusion, cys-LT antagonist treatment reduces lung symptoms subsequent to RSV bronchiolitis.<\/jats:p>","DOI":"10.1164\/rccm.200207-747oc","type":"journal-article","created":{"date-parts":[[2003,1,28]],"date-time":"2003-01-28T16:04:48Z","timestamp":1043769888000},"page":"379-383","source":"Crossref","is-referenced-by-count":177,"title":["A Randomized Trial of Montelukast in Respiratory Syncytial Virus Postbronchiolitis"],"prefix":"10.1093","volume":"167","author":[{"given":"Hans","family":"Bisgaard","sequence":"first","affiliation":[{"name":"Copenhagen Studies on Asthma in Childhood (COPSAC), Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2003,2,1]]},"reference":[{"key":"2026031623240556100_BIB1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1086\/317655","volume":"183","year":"2001","journal-title":"J Infect Dis"},{"key":"2026031623240556100_BIB2","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1164\/ajrccm.163.supplement_1.2011109","volume":"163","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"2026031623240556100_BIB3","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1164\/ajrccm.161.5.9906076","volume":"161","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"2026031623240556100_BIB4","first-page":"1","volume":"135","year":"1999","journal-title":"J Pediatr"},{"key":"2026031623240556100_BIB5","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0140-6736(98)10321-5","volume":"354","year":"1999","journal-title":"Lancet"},{"key":"2026031623240556100_BIB6"},{"key":"2026031623240556100_BIB7","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0140-6736(96)02285-4","volume":"348","year":"1996","journal-title":"Lancet"},{"key":"2026031623240556100_BIB8","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0022-3476(97)70342-1","volume":"130","year":"1997","journal-title":"J Pediatr"},{"key":"2026031623240556100_BIB9","doi-asserted-by":"crossref","first-page":"E77","DOI":"10.1542\/peds.104.6.e77","volume":"104","year":"1999","journal-title":"Pediatrics"},{"key":"2026031623240556100_BIB10","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0022-3476(98)70316-6","volume":"132","year":"1998","journal-title":"J Pediatr"},{"key":"2026031623240556100_BIB11","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1136\/adc.80.4.343","volume":"80","year":"1999","journal-title":"Arch Dis Child"},{"key":"2026031623240556100_BIB12","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1136\/adc.82.2.126","volume":"82","year":"2000","journal-title":"Arch Dis Child"},{"key":"2026031623240556100_BIB13","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1067\/mai.2000.108604","volume":"106","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"2026031623240556100_BIB14","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1203\/00006450-198810000-00018","volume":"24","year":"1988","journal-title":"Pediatr Res"},{"key":"2026031623240556100_BIB15","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0022-3476(88)80058-1","volume":"112","year":"1988","journal-title":"J Pediatr"},{"key":"2026031623240556100_BIB16","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0091-6749(99)70235-6","volume":"103","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"2026031623240556100_BIB17","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1542\/peds.107.2.381","volume":"107","year":"2001","journal-title":"Pediatrics"},{"key":"2026031623240556100_BIB18","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1067\/mai.2000.110478","volume":"106","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"2026031623240556100_BIB19","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1164\/ajrccm.160.1.9811024","volume":"160","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"2026031623240556100_BIB20","doi-asserted-by":"crossref","first-page":"E48","DOI":"10.1542\/peds.108.3.e48","volume":"108","year":"2001","journal-title":"Pediatrics"},{"key":"2026031623240556100_BIB21","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0022-3476(05)80592-X","volume":"120","year":"1992","journal-title":"J Pediatr"},{"key":"2026031623240556100_BIB22","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1164\/ajrccm\/151.5_Pt_1.1678","volume":"151","year":"1995","journal-title":"Am J Respir Crit Care Med"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/167\/3\/379\/67346741\/ajrccm_167_3_379.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/167\/3\/379\/67346741\/ajrccm_167_3_379.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T03:31:16Z","timestamp":1773718276000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/167\/3\/379\/8519653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,2,1]]},"references-count":22,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2003,2,1]]},"published-print":{"date-parts":[[2003,2,1]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.200207-747oc","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.720126105.793500607","asserted-by":"object"}]},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2003,2]]},"published":{"date-parts":[[2003,2,1]]}}}