{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:03:04Z","timestamp":1791302584598,"version":"4.1.0"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Interferon (IFN)-\u03b3 was recently proposed as a treatment for idiopathic pulmonary fibrosis. We report on four patients who developed acute respiratory failure with new alveolar opacities after 2 (two patients), 6, and 35 injections of IFN-\u03b3-1b. All four patients had advanced idiopathic pulmonary fibrosis (total lung capacity less than 45% predicted or carbon monoxide diffusion capacity less than 30% predicted), and two patients had familial pulmonary fibrosis. No other cause of deterioration was found. Refractory hypoxemia led to death in three cases and to lung transplantation in one case. Pathologic studies in two patients showed diffuse alveolar damage lesions with preexisting usual interstitial pneumonia. These cases suggest that IFN-\u03b3 therapy can induce an acute respiratory failure in patients with end-stage idiopathic pulmonary fibrosis.<\/jats:p>","DOI":"10.1164\/rccm.200208-818cr","type":"journal-article","created":{"date-parts":[[2003,3,27]],"date-time":"2003-03-27T18:45:07Z","timestamp":1048790707000},"page":"953-957","source":"Crossref","is-referenced-by-count":82,"title":["Acute Respiratory Failure after Interferon-\u03b3 Therapy of End-Stage Pulmonary Fibrosis"],"prefix":"10.1093","volume":"167","author":[{"given":"Isabelle","family":"Honor\u00e9","sequence":"first","affiliation":[{"name":"Service de Pneumologie, and Unit\u00e9 INSERM 408, H\u00f4pital Bichat, Paris; Service d'Anatomie pathologique, H\u00f4pital Beaujon, Clichy; Service d'Anatomie Pathologique, H\u00f4pital Avicenne, Bobigny; Service de Pneumologie and EA 2363, H\u00f4pital Avicenne, Bobigny, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilario","family":"Nunes","sequence":"additional","affiliation":[{"name":"Service de Pneumologie, and Unit\u00e9 INSERM 408, H\u00f4pital Bichat, Paris; Service d'Anatomie pathologique, H\u00f4pital Beaujon, Clichy; Service d'Anatomie Pathologique, H\u00f4pital Avicenne, Bobigny; Service de Pneumologie and EA 2363, H\u00f4pital Avicenne, Bobigny, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odile","family":"Groussard","sequence":"additional","affiliation":[{"name":"Service de Pneumologie, and Unit\u00e9 INSERM 408, H\u00f4pital Bichat, Paris; Service d'Anatomie pathologique, H\u00f4pital Beaujon, Clichy; Service d'Anatomie Pathologique, H\u00f4pital Avicenne, Bobigny; Service de Pneumologie and EA 2363, H\u00f4pital Avicenne, Bobigny, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Kambouchner","sequence":"additional","affiliation":[{"name":"Service de Pneumologie, and Unit\u00e9 INSERM 408, H\u00f4pital Bichat, Paris; Service d'Anatomie pathologique, H\u00f4pital Beaujon, Clichy; Service d'Anatomie Pathologique, H\u00f4pital Avicenne, Bobigny; Service de Pneumologie and EA 2363, H\u00f4pital Avicenne, Bobigny, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Chambellan","sequence":"additional","affiliation":[{"name":"Service de Pneumologie, and Unit\u00e9 INSERM 408, H\u00f4pital Bichat, Paris; Service d'Anatomie pathologique, H\u00f4pital Beaujon, Clichy; Service d'Anatomie Pathologique, H\u00f4pital Avicenne, Bobigny; Service de Pneumologie and EA 2363, H\u00f4pital Avicenne, Bobigny, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Aubier","sequence":"additional","affiliation":[{"name":"Service de Pneumologie, and Unit\u00e9 INSERM 408, H\u00f4pital Bichat, Paris; Service d'Anatomie pathologique, H\u00f4pital Beaujon, Clichy; Service d'Anatomie Pathologique, H\u00f4pital Avicenne, Bobigny; 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