{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:27:00Z","timestamp":1778632020340,"version":"3.51.4"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2003,7,1]],"date-time":"2003-07-01T00:00:00Z","timestamp":1057017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Despite advances in the management of myeloablative allogeneic hematopoietic stem cell transplants, airflow obstruction (AFO) remains a significant complication. We conducted a 12-year study to examine the recent epidemiology of AFO and its associated mortality. Using the rate of percent predicted FEV1 decline after transplant, we defined AFO as a more than 5% per year decline in percent predicted FEV1 with the lowest post-transplant FEV1\/FVC ratio less than 0.8. New obstruction was more frequent than previous estimates (26% overall, 32% among patients with chronic graft-versus-host disease [GVHD]) and was significantly associated with older age at transplant, lower pretransplant FEV1\/FVC ratio, history of both acute and chronic GVHD, and respiratory viral infection within the first 100 days after transplant. AFO was associated with significant attributable mortality rates of 9% at 3 years, 12% at 5 years, and 18% at 10 years after transplant, which were much higher for the subpopulation of patients with chronic GVHD (22% at 3 years, 27% at 5 years, and 40% at 10 years). These results suggest that the incidence of AFO may have been underestimated previously, and its presence significantly increases the mortality of long-term survivors of myeloablative allogeneic hematopoietic stem cell transplant patients.<\/jats:p>","DOI":"10.1164\/rccm.200212-1468oc","type":"journal-article","created":{"date-parts":[[2003,3,24]],"date-time":"2003-03-24T20:53:17Z","timestamp":1048539197000},"page":"208-214","source":"Crossref","is-referenced-by-count":213,"title":["Airflow Obstruction after Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation"],"prefix":"10.1093","volume":"168","author":[{"given":"Jason W.","family":"Chien","sequence":"first","affiliation":[{"name":"Division of Clinical Research, Fred Hutchinson Cancer Research Center; and Department of Epidemiology, University of Washington, Seattle, Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"Martin","sequence":"additional","affiliation":[{"name":"Division of Clinical Research, Fred Hutchinson Cancer Research Center; and Department of Epidemiology, University of Washington, Seattle, Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ted A.","family":"Gooley","sequence":"additional","affiliation":[{"name":"Division of Clinical Research, Fred Hutchinson Cancer Research Center; and Department of Epidemiology, University of Washington, Seattle, Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary E.","family":"Flowers","sequence":"additional","affiliation":[{"name":"Division of Clinical Research, Fred Hutchinson Cancer Research Center; and Department of Epidemiology, University of Washington, Seattle, Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan R.","family":"Heckbert","sequence":"additional","affiliation":[{"name":"Division of Clinical Research, Fred Hutchinson Cancer Research Center; and Department of Epidemiology, University of Washington, Seattle, Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. Garrett","family":"Nichols","sequence":"additional","affiliation":[{"name":"Division of Clinical Research, Fred Hutchinson Cancer Research Center; and Department of Epidemiology, University of Washington, Seattle, Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan G.","family":"Clark","sequence":"additional","affiliation":[{"name":"Division of Clinical Research, Fred Hutchinson Cancer Research Center; and Department of Epidemiology, University of Washington, Seattle, Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2003,7,15]]},"reference":[{"key":"2026050506570931700_BIB1","first-page":"641","volume-title":"Am Rev Respir Dis","year":"1984"},{"key":"2026050506570931700_BIB2","first-page":"828","volume-title":"Chest","year":"1985"},{"key":"2026050506570931700_BIB3","first-page":"370","volume-title":"J 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