{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T23:04:18Z","timestamp":1774566258226,"version":"3.50.1"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2003,10,1]],"date-time":"2003-10-01T00:00:00Z","timestamp":1064966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The lung collectin surfactant protein D (SP-D) is an important component of the innate immune response but is also believed to play a role in other regulatory aspects of immune and inflammatory responses within the lung. The role of SP-D in the development of allergen-induced airway inflammation and hyperresponsiveness (AHR) is not well defined. SP-D levels progressively increased up to 48 hours after allergen challenge of sensitized mice and then subsequently decreased. The levels of SP-D paralleled the development of airway eosinophilia and AHR. To determine if this association was functionally relevant, mice were administered rat SP-D (rSP-D) intratracheally. When given to sensitized mice before challenge, AHR and eosinophilia were reduced by rSP-D in a dose-dependent manner but not by mutant rSP-D. rSP-D administration resulted in increased levels of interleukin (IL)-10, IL-12, and IFN-\u03b3 in bronchoalveolar lavage fluid and reduced goblet cell hyperplasia. Culture of alveolar macrophages together with SP-D and allergen resulted in increased production of IL-10, IL-12, and IFN-\u03b3. These results indicate that SP-D can (negatively) regulate the development of AHR and airway inflammation after airway challenge of sensitized mice, at least in part, by modulating the function of alveolar macrophages.<\/jats:p>","DOI":"10.1164\/rccm.200304-548oc","type":"journal-article","created":{"date-parts":[[2003,7,28]],"date-time":"2003-07-28T20:27:29Z","timestamp":1059424049000},"page":"783-789","source":"Crossref","is-referenced-by-count":61,"title":["Surfactant Protein D Regulates Airway Function and Allergic Inflammation through Modulation of Macrophage Function"],"prefix":"10.1093","volume":"168","author":[{"given":"Katsuyuki","family":"Takeda","sequence":"first","affiliation":[{"name":"Program in Cell Biology, Department of Pediatrics; and Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuaki","family":"Miyahara","sequence":"additional","affiliation":[{"name":"Program 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