{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T23:09:51Z","timestamp":1774566591272,"version":"3.50.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>It is difficult to distinguish young children with respiratory symptoms who will develop asthma from those with transient symptoms only. Measurement of interrupter resistance may help to identify children at high risk of asthma. The aim of this study is to compare interrupter resistance in 4-year-old children with different wheezing phenotypes. All children participated in the Prevention and Incidence of Asthma and Mite Allergy cohort, a prospective birth cohort of more than 4,000 children. At 4 years of age, data on interrupter resistance plus wheezing phenotype were available for 838 children. Mean interrupter resistance values (95% confidence interval) were 0.95 (0.93, 0.97), 0.95 (0.92, 0.98), 0.96 (0.87, 1.05), and 1.08 (1.02, 1.14) kPa \u00b7 L\u22121 \u00b7 second for never (n = 482), early transient (n = 236), late-onset (n = 22), and persistent (n = 98) wheezing phenotypes, respectively. Additional analyses were performed for children with atopic and nonatopic mothers separately. Both in children with atopic and nonatopic mothers, children with persistent wheeze had significantly higher interrupter resistance values than children with never and early wheeze. In conclusion, mean interrupter resistance values were higher in children with persistent wheeze as compared with children with never and early transient wheezing phenotypes.<\/jats:p>","DOI":"10.1164\/rccm.200306-800oc","type":"journal-article","created":{"date-parts":[[2003,11,3]],"date-time":"2003-11-03T21:09:15Z","timestamp":1067893755000},"page":"209-213","source":"Crossref","is-referenced-by-count":50,"title":["Interrupter Resistance and Wheezing Phenotypes at 4 Years of Age"],"prefix":"10.1093","volume":"169","author":[{"given":"Jessica E.","family":"Brussee","sequence":"first","affiliation":[{"name":"Center for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven; Division of Respiratory Medicine, Department of Pediatrics, Sophia's Children's Hospital, Erasmus University Medical Center, Rotterdam; Department of Epidemiology and Statistics, University of Groningen, Groningen; Institute for Risk Assessment Sciences, Utrecht University, Utrecht; Department of Paediatric Respiratory Medicine, University Hospital Groningen, Groningen; and Julius Center for Health Sciences and Primary Care, Utrecht University Medical Center, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrie\u0308tte A.","family":"Smit","sequence":"additional","affiliation":[{"name":"Center for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven; Division of Respiratory Medicine, Department of Pediatrics, Sophia's Children's Hospital, Erasmus University Medical Center, Rotterdam; Department of Epidemiology and Statistics, University of Groningen, Groningen; Institute for Risk Assessment Sciences, Utrecht University, Utrecht; Department of Paediatric Respiratory Medicine, University Hospital Groningen, Groningen; and Julius Center for Health Sciences and Primary Care, Utrecht University Medical Center, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurens P.","family":"Koopman","sequence":"additional","affiliation":[{"name":"Center for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven; Division of Respiratory Medicine, Department of Pediatrics, Sophia's Children's Hospital, Erasmus University Medical Center, Rotterdam; Department of Epidemiology and Statistics, University of Groningen, Groningen; Institute for Risk Assessment Sciences, Utrecht University, Utrecht; Department of Paediatric Respiratory Medicine, University Hospital Groningen, Groningen; and Julius Center for Health Sciences and Primary Care, Utrecht University Medical Center, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alet H.","family":"Wijga","sequence":"additional","affiliation":[{"name":"Center for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven; Division of Respiratory Medicine, Department of Pediatrics, Sophia's Children's Hospital, Erasmus University Medical Center, Rotterdam; Department of Epidemiology and Statistics, University of Groningen, Groningen; Institute for Risk Assessment Sciences, Utrecht University, Utrecht; Department of Paediatric Respiratory Medicine, University Hospital Groningen, Groningen; and Julius Center for Health Sciences and Primary Care, Utrecht University Medical Center, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjan","family":"Kerkhof","sequence":"additional","affiliation":[{"name":"Center for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven; Division of Respiratory Medicine, Department of Pediatrics, Sophia's Children's Hospital, Erasmus University Medical Center, Rotterdam; Department of Epidemiology and Statistics, University of Groningen, Groningen; Institute for Risk Assessment Sciences, Utrecht University, Utrecht; Department of Paediatric Respiratory Medicine, University Hospital Groningen, Groningen; and Julius Center for Health Sciences and Primary Care, Utrecht University Medical Center, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Corver","sequence":"additional","affiliation":[{"name":"Center for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven; Division of Respiratory Medicine, Department of Pediatrics, Sophia's Children's Hospital, Erasmus University Medical Center, Rotterdam; Department of Epidemiology and Statistics, University of Groningen, Groningen; Institute for Risk Assessment Sciences, Utrecht University, Utrecht; Department of Paediatric Respiratory Medicine, University Hospital Groningen, Groningen; and Julius Center for Health Sciences and Primary Care, Utrecht University Medical Center, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ada P. H.","family":"Vos","sequence":"additional","affiliation":[{"name":"Center for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven; Division of Respiratory Medicine, Department of Pediatrics, Sophia's Children's Hospital, Erasmus University Medical Center, Rotterdam; Department of Epidemiology and Statistics, University of Groningen, Groningen; Institute for Risk Assessment Sciences, Utrecht University, Utrecht; Department of Paediatric Respiratory Medicine, University Hospital Groningen, Groningen; and Julius Center for Health Sciences and Primary Care, Utrecht University Medical Center, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorrit","family":"Gerritsen","sequence":"additional","affiliation":[{"name":"Center for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven; Division of Respiratory Medicine, Department of Pediatrics, Sophia's Children's Hospital, Erasmus University Medical Center, Rotterdam; Department of Epidemiology and Statistics, University of Groningen, Groningen; Institute for Risk Assessment Sciences, Utrecht University, Utrecht; Department of Paediatric Respiratory Medicine, University Hospital Groningen, Groningen; and Julius Center for Health Sciences and Primary Care, Utrecht University Medical Center, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diederick E.","family":"Grobbee","sequence":"additional","affiliation":[{"name":"Center for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven; Division of Respiratory Medicine, Department of Pediatrics, Sophia's Children's Hospital, Erasmus University Medical Center, Rotterdam; Department of Epidemiology and Statistics, University of Groningen, Groningen; Institute for Risk Assessment Sciences, Utrecht University, Utrecht; Department of Paediatric Respiratory Medicine, University Hospital Groningen, Groningen; and Julius Center for Health Sciences and Primary Care, Utrecht University Medical Center, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bert","family":"Brunekreef","sequence":"additional","affiliation":[{"name":"Center for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven; Division of Respiratory Medicine, Department of Pediatrics, Sophia's Children's Hospital, Erasmus University Medical Center, Rotterdam; Department of Epidemiology and Statistics, University of Groningen, Groningen; Institute for Risk Assessment Sciences, Utrecht University, Utrecht; Department of Paediatric Respiratory Medicine, University Hospital Groningen, Groningen; and Julius Center for Health Sciences and Primary Care, Utrecht University Medical Center, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J. 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