{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:43:42Z","timestamp":1790318622029,"version":"4.1.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Increased Th2 cytokine production in asthma is widely accepted, but excess production by asthmatic human airway CD4+ T cells has not been demonstrated, nor has a relationship with disease severity. The importance of airway CD8+ T cell type 1 and type 2 cytokine production in asthma is unknown. We investigated frequencies of IFN-\u03b3, interleukin (IL)-4 and IL-5 producing CD4+ and CD8+ blood and sputum T cells from normal subjects and subjects with asthma and compared between cell subsets, subject groups, and body compartments with and without in vitro stimulation and investigated relationships between cytokine production and asthma severity. Production of IL-4, IL-5, and IFN-\u03b3 by unstimulated sputum CD4+ and CD8+ T cells was increased in subjects with asthma and related to disease severity, more for CD8+ than for CD4+ T cells. Frequencies of sputum CD8+ T cells producing type 1 and type 2 cytokines were similar to those of CD4+ T cells. In vitro stimulation polarized peripheral blood cytokine production toward IFN-\u03b3 production, significantly more in subjects with asthma than in normal subjects. These data demonstrate increased type 1 and 2 cytokine production in CD4+ and CD8+ T cells in sputum and relate production to disease severity. Findings in blood did not reflect those in airways.<\/jats:p>","DOI":"10.1164\/rccm.200310-1416oc","type":"journal-article","created":{"date-parts":[[2004,10,22]],"date-time":"2004-10-22T20:25:09Z","timestamp":1098476709000},"page":"224-230","source":"Crossref","is-referenced-by-count":173,"title":["Increased Interleukin-4, Interleukin-5, and Interferon-\u03b3 in Airway CD4+ and CD8+ T Cells in Atopic Asthma"],"prefix":"10.1093","volume":"171","author":[{"given":"Sang-Heon","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; Infection, Inflammation and Repair Division, University of Southampton, Southampton; and Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luminita A.","family":"Stanciu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; Infection, Inflammation and Repair Division, University of Southampton, Southampton; and Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen T.","family":"Holgate","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; Infection, Inflammation and Repair Division, University of Southampton, Southampton; and Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian L.","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; Infection, Inflammation and Repair Division, University of Southampton, Southampton; and Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,2,1]]},"reference":[{"key":"2026032606173352500_BIB1","first-page":"1038","volume-title":"Am J Respir Crit Care Med","year":"1994"},{"key":"2026032606173352500_BIB2","first-page":"298","volume-title":"N Engl J Med","year":"1992"},{"key":"2026032606173352500_BIB3","first-page":"238","volume-title":"J Allergy Clin Immunol","year":"1999"},{"key":"2026032606173352500_BIB4","first-page":"3539","volume-title":"J Immunol","year":"1997"},{"key":"2026032606173352500_BIB5","first-page":"515","volume-title":"J Allergy Clin Immunol","year":"1995"},{"key":"2026032606173352500_BIB6","first-page":"2142","volume-title":"J 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