{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T10:22:32Z","timestamp":1793701352775,"version":"4.5.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The tuberculin skin test for immunologic diagnosis of Mycobacterium tuberculosis infection has many limitations, including being confounded by bacillus Calmette-Gue\u0301rin (BCG) vaccination or exposure to nontuberculous mycobacteria. M. tuberculosis\u2013specific antigens that are absent from BCG and most nontuberculous mycobacteria have been identified. We examined the use of two of these antigens, CFP-10 and ESAT-6, in a whole blood IFN-\u03b3 assay as a diagnostic test for tuberculosis in BCG-vaccinated individuals. Because of the lack of an accurate standard with which to compare new tests for M. tuberculosis infection, specificity of the whole blood IFN-\u03b3 assay was estimated on the basis of data from people with no identified risk for M. tuberculosis exposure (216 BCG-vaccinated Japanese adults) and sensitivity was estimated on the basis of data from 118 patients with culture-confirmed M. tuberculosis infection who had received less than 1 week of treatment. Using a combination of CFP-10 and ESAT-6 responses, the specificity of the test for the low-risk group was 98.1% and the sensitivity for patients with M. tuberculosis infection was 89.0%. The results demonstrate that the whole blood IFN-\u03b3 assay using CFP-10 and ESAT-6 was highly specific and sensitive for M. tuberculosis infection and was unaffected by BCG vaccination status.<\/jats:p>","DOI":"10.1164\/rccm.200402-179oc","type":"journal-article","created":{"date-parts":[[2004,4,5]],"date-time":"2004-04-05T20:43:40Z","timestamp":1081197820000},"page":"59-64","source":"Crossref","is-referenced-by-count":470,"title":["Specific Detection of Tuberculosis Infection"],"prefix":"10.1093","volume":"170","author":[{"given":"Toru","family":"Mori","sequence":"first","affiliation":[{"name":"Research Institute of Tuberculosis and National Tokyo Hospital, Tokyo; National Kinki Chuo Hospital for Chest Diseases and Osaka Prefectural Habikino Hospital, Osaka; National Chiba Higashi Hospital and Chiba University School of Medicine, Chiba; and National Hiroshima Hospital, Hiroshima, Japan; and Centers for Disease Control and Prevention and Emory University School of Medicine, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsunori","family":"Sakatani","sequence":"additional","affiliation":[{"name":"Research Institute of Tuberculosis and National Tokyo Hospital, Tokyo; National Kinki Chuo Hospital for Chest Diseases and Osaka Prefectural Habikino Hospital, Osaka; National Chiba Higashi Hospital and Chiba University School of Medicine, Chiba; and National Hiroshima Hospital, Hiroshima, Japan; and Centers for Disease Control and Prevention and Emory University School of Medicine, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumio","family":"Yamagishi","sequence":"additional","affiliation":[{"name":"Research Institute of Tuberculosis and National Tokyo Hospital, Tokyo; National Kinki Chuo Hospital for Chest Diseases and Osaka Prefectural Habikino Hospital, Osaka; National Chiba Higashi Hospital and Chiba University School of Medicine, Chiba; and National Hiroshima Hospital, Hiroshima, Japan; and Centers for Disease Control and Prevention and Emory University School of Medicine, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Takashima","sequence":"additional","affiliation":[{"name":"Research Institute of Tuberculosis and National Tokyo Hospital, Tokyo; National Kinki Chuo Hospital for Chest Diseases and Osaka Prefectural Habikino Hospital, Osaka; National Chiba Higashi Hospital and Chiba University School of Medicine, Chiba; and National Hiroshima Hospital, Hiroshima, Japan; and Centers for Disease Control and Prevention and Emory University School of Medicine, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Kawabe","sequence":"additional","affiliation":[{"name":"Research Institute of Tuberculosis and National Tokyo Hospital, Tokyo; National Kinki Chuo Hospital for Chest Diseases and Osaka Prefectural Habikino Hospital, Osaka; National Chiba Higashi Hospital and Chiba University School of Medicine, Chiba; and National Hiroshima Hospital, Hiroshima, Japan; and Centers for Disease Control and Prevention and Emory University School of Medicine, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Nagao","sequence":"additional","affiliation":[{"name":"Research Institute of Tuberculosis and National Tokyo Hospital, Tokyo; National Kinki Chuo Hospital for Chest Diseases and Osaka Prefectural Habikino Hospital, Osaka; National Chiba Higashi Hospital and Chiba University School of Medicine, Chiba; and National Hiroshima Hospital, Hiroshima, Japan; and Centers for Disease Control and Prevention and Emory University School of Medicine, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriko","family":"Shigeto","sequence":"additional","affiliation":[{"name":"Research Institute of Tuberculosis and National Tokyo Hospital, Tokyo; National Kinki Chuo Hospital for Chest Diseases and Osaka Prefectural Habikino Hospital, Osaka; National Chiba Higashi Hospital and Chiba University School of Medicine, Chiba; and National Hiroshima Hospital, Hiroshima, Japan; and Centers for Disease Control and Prevention and Emory University School of Medicine, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Harada","sequence":"additional","affiliation":[{"name":"Research Institute of Tuberculosis and National Tokyo Hospital, Tokyo; National Kinki Chuo Hospital for Chest Diseases and Osaka Prefectural Habikino Hospital, Osaka; National Chiba Higashi Hospital and Chiba University School of Medicine, Chiba; and National Hiroshima Hospital, Hiroshima, Japan; and Centers for Disease Control and Prevention and Emory University School of Medicine, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Mitarai","sequence":"additional","affiliation":[{"name":"Research Institute of Tuberculosis and National Tokyo Hospital, Tokyo; National Kinki Chuo Hospital for Chest Diseases and Osaka Prefectural Habikino Hospital, Osaka; National Chiba Higashi Hospital and Chiba University School of Medicine, Chiba; and National Hiroshima Hospital, Hiroshima, Japan; and Centers for Disease Control and Prevention and Emory University School of Medicine, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaji","family":"Okada","sequence":"additional","affiliation":[{"name":"Research Institute of Tuberculosis and National Tokyo Hospital, Tokyo; National Kinki Chuo Hospital for Chest Diseases and Osaka Prefectural Habikino Hospital, Osaka; National Chiba Higashi Hospital and Chiba University School of Medicine, Chiba; and National Hiroshima Hospital, Hiroshima, Japan; and Centers for Disease Control and Prevention and Emory University School of Medicine, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiro","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Research Institute of Tuberculosis and National Tokyo Hospital, Tokyo; National Kinki Chuo Hospital for Chest Diseases and Osaka Prefectural Habikino Hospital, Osaka; National Chiba Higashi Hospital and Chiba University School of Medicine, Chiba; and National Hiroshima Hospital, Hiroshima, Japan; and Centers for Disease Control and Prevention and Emory University School of Medicine, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshikazu","family":"Inoue","sequence":"additional","affiliation":[{"name":"Research Institute of Tuberculosis and National Tokyo Hospital, Tokyo; National Kinki Chuo Hospital for Chest Diseases and Osaka Prefectural Habikino Hospital, Osaka; National Chiba Higashi Hospital and Chiba University School of Medicine, Chiba; and National Hiroshima Hospital, Hiroshima, Japan; and Centers for Disease Control and Prevention and Emory University School of Medicine, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunari","family":"Tsuyuguchi","sequence":"additional","affiliation":[{"name":"Research Institute of Tuberculosis and National Tokyo Hospital, Tokyo; National Kinki Chuo Hospital for Chest Diseases and Osaka Prefectural Habikino Hospital, Osaka; National Chiba Higashi Hospital and Chiba University School of Medicine, Chiba; and National Hiroshima Hospital, Hiroshima, Japan; and Centers for Disease Control and Prevention and Emory University School of Medicine, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Research Institute of Tuberculosis and National Tokyo Hospital, Tokyo; National Kinki Chuo Hospital for Chest Diseases and Osaka Prefectural Habikino Hospital, Osaka; National Chiba Higashi Hospital and Chiba University School of Medicine, Chiba; and National Hiroshima Hospital, Hiroshima, Japan; and Centers for Disease Control and Prevention and Emory University School of Medicine, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald H.","family":"Mazurek","sequence":"additional","affiliation":[{"name":"Research Institute of Tuberculosis and National Tokyo Hospital, Tokyo; National Kinki Chuo Hospital for Chest Diseases and Osaka Prefectural Habikino Hospital, Osaka; National Chiba Higashi Hospital and Chiba University School of Medicine, Chiba; and National Hiroshima Hospital, Hiroshima, Japan; and Centers for Disease Control and Prevention and Emory University School of Medicine, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izuo","family":"Tsuyuguchi","sequence":"additional","affiliation":[{"name":"Research Institute of Tuberculosis and National Tokyo Hospital, Tokyo; 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