{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:02:14Z","timestamp":1793412134145,"version":"4.5.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The blood beryllium lymphocyte proliferation test is used in medical surveillance to identify both beryllium sensitization and chronic beryllium disease. Approximately 50% of individuals with beryllium sensitization have chronic beryllium disease at the time of their initial clinical evaluation; however, the rate of progression from beryllium sensitization to chronic beryllium disease is unknown. We monitored a cohort of beryllium-sensitized patients at 2-year intervals, using bronchoalveolar lavage and repeated transbronchial lung biopsies to determine progression to chronic beryllium disease as evidenced by granulomatous inflammation in lung tissue. Fifty-five individuals with beryllium sensitization were monitored with a range of 2 to 5 clinical evaluations. Disease developed in 17 sensitized individuals (31%) within an average follow-up period of 3.8 years (range, 1.0\u20139.5 years). Thirty-eight of the 55 (69%) remained beryllium sensitized without disease after an average follow-up time of 4.8 years (range, 1.7\u201311.6 years). Progressors were more likely to have worked as machinists. We found no difference in average age, sex, race or ethnicity, smoking status, or beryllium exposure time between those who progressed to chronic beryllium disease and those who remained sensitized without disease. We conclude that beryllium sensitization is an adverse health effect in beryllium-exposed workers and merits medical follow-up.<\/jats:p>","DOI":"10.1164\/rccm.200402-190oc","type":"journal-article","created":{"date-parts":[[2004,9,16]],"date-time":"2004-09-16T20:24:33Z","timestamp":1095366273000},"page":"54-60","source":"Crossref","is-referenced-by-count":146,"title":["Beryllium Sensitization Progresses to Chronic Beryllium Disease"],"prefix":"10.1093","volume":"171","author":[{"given":"Lee S.","family":"Newman","sequence":"first","affiliation":[{"name":"Division of Environmental and Occupational Health Sciences and Division of Pulmonary Medicine, Department of Medicine, National Jewish Medical and Research Center; and Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine and Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret M.","family":"Mroz","sequence":"additional","affiliation":[{"name":"Division of Environmental and Occupational Health Sciences and Division of Pulmonary Medicine, Department of Medicine, National Jewish Medical and Research Center; and Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine and Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Balkissoon","sequence":"additional","affiliation":[{"name":"Division of Environmental and Occupational Health Sciences and Division of Pulmonary Medicine, Department of Medicine, National Jewish Medical and Research Center; and Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine and Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Maier","sequence":"additional","affiliation":[{"name":"Division of Environmental and Occupational Health Sciences and Division of Pulmonary Medicine, Department of Medicine, National Jewish Medical and Research Center; and Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine and Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,1,1]]},"reference":[{"key":"2026032606152391600_BIB1","first-page":"603","volume-title":"J Occup Med","year":"1989"},{"key":"2026032606152391600_BIB2","first-page":"54","volume-title":"J Allergy Clin Immunol","year":"1991"},{"key":"2026032606152391600_BIB3","first-page":"985","volume-title":"Am Rev Respir Dis","year":"1993"},{"key":"2026032606152391600_BIB4","first-page":"267","volume-title":"J Occup Med","year":"1993"},{"key":"2026032606152391600_BIB5","first-page":"16","volume-title":"Am J Ind Med","year":"1996"},{"key":"2026032606152391600_BIB6","first-page":"981","volume-title":"Environ Health Perspect","year":"1996"},{"key":"2026032606152391600_BIB7","first-page":"605","volume-title":"Occup Environ Med","year":"1997"},{"key":"2026032606152391600_BIB8","first-page":"405","volume-title":"Appl Occup Environ Hyg","year":"2001"},{"key":"2026032606152391600_BIB9","first-page":"231","volume-title":"J Occup Environ Med","year":"2001"},{"key":"2026032606152391600_BIB10","first-page":"167","volume-title":"Int Arch Occup Environ Health","year":"2001"},{"key":"2026032606152391600_BIB11","first-page":"579","volume-title":"Appl Occup Environ Hyg","year":"2001"},{"key":"2026032606152391600_BIB12","first-page":"953","volume-title":"Environ Health Perspect","year":"1996"},{"key":"2026032606152391600_BIB13","first-page":"A145","volume-title":"Am J Respir Crit Care Med","year":"1998"},{"key":"2026032606152391600_BIB14"},{"key":"2026032606152391600_BIB15"},{"key":"2026032606152391600_BIB16","first-page":"1","volume-title":"J Clin Invest","year":"1957"},{"key":"2026032606152391600_BIB17","first-page":"1702","volume-title":"Chest","year":"2001"},{"key":"2026032606152391600_BIB18","first-page":"1479","volume-title":"Am Rev Respir Dis","year":"1989"},{"key":"2026032606152391600_BIB19","first-page":"990","volume-title":"Clin Diagn Lab Immunol","year":"2003"},{"key":"2026032606152391600_BIB20","first-page":"1137","volume-title":"Am J Pathol","year":"1948"},{"key":"2026032606152391600_BIB21"},{"key":"2026032606152391600_BIB22","first-page":"661","volume-title":"Am Rev Respir Dis","year":"1993"},{"key":"2026032606152391600_BIB23","first-page":"400","volume-title":"Chest","year":"1980"},{"key":"2026032606152391600_BIB24","first-page":"166","volume-title":"J Pharmacol Exp Ther","year":"2000"},{"key":"2026032606152391600_BIB25","first-page":"238","volume-title":"J Occup Environ Med","year":"2001"},{"key":"2026032606152391600_BIB26","first-page":"242","volume-title":"Science","year":"1993"},{"key":"2026032606152391600_BIB27","first-page":"337","volume-title":"Am J Ind Med","year":"1997"},{"key":"2026032606152391600_BIB28","first-page":"27","volume-title":"Toxicology","year":"2001"},{"key":"2026032606152391600_BIB29","first-page":"1192","volume-title":"Am J Respir Crit Care Med","year":"2001"},{"key":"2026032606152391600_BIB30","first-page":"677","volume-title":"Eur Respir J","year":"2001"},{"key":"2026032606152391600_BIB31","first-page":"788","volume-title":"Am J Respir Crit Care Med","year":"2002"},{"key":"2026032606152391600_BIB32","first-page":"6910","volume-title":"J Immunol","year":"2003"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/171\/1\/54\/67490019\/ajrccm_171_1_54.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/171\/1\/54\/67490019\/ajrccm_171_1_54.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T10:15:25Z","timestamp":1774520125000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/171\/1\/54\/8537978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1,1]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2005,1,1]]},"published-print":{"date-parts":[[2005,1,1]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.200402-190oc","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2005,1]]},"published":{"date-parts":[[2005,1,1]]}}}