{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T22:32:22Z","timestamp":1774564342600,"version":"3.50.1"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In the present study it was determined whether a pharmacologic approach to blocking receptor tyrosine kinase-mediated activation during allergic airway responses could be beneficial. To examine these responses, allergic mice were given a single oral dose of imatinib at clinically relevant concentrations, ranging from 0.05 to 50 mg\/kg, by oral gavages just before allergen challenge. The reduction in the allergen-induced responses was significant and centered on reducing overall inflammation as well as pulmonary cytokine levels. In particular, the treatment of the mice with imatinib significantly attenuated airway hyperreactivity and peribronchial eosinophil accumulation, and significantly reduced Th2 cytokines, interleukin-4 and interleukin-13. In addition, chemokines previously associated with allergen-induced pulmonary disease, CCL2, CCL5, and CCL6, were significantly reduced in the lungs of the imatinib-treated animals. Together these data demonstrate that the pharmacologic inhibitor imatinib may provide a clinically attractive therapy for allergic, asthmatic responses.<\/jats:p>","DOI":"10.1164\/rccm.200403-385oc","type":"journal-article","created":{"date-parts":[[2004,9,16]],"date-time":"2004-09-16T20:24:33Z","timestamp":1095366273000},"page":"35-39","source":"Crossref","is-referenced-by-count":59,"title":["Treatment of Cockroach Allergen Asthma Model with Imatinib Attenuates Airway Responses"],"prefix":"10.1093","volume":"171","author":[{"given":"Aaron A.","family":"Berlin","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas W.","family":"Lukacs","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,1,1]]},"reference":[{"key":"2026032606155120400_BIB1","first-page":"1033","volume-title":"J Allergy Clin Immunol","year":"2000"},{"key":"2026032606155120400_BIB2","first-page":"4","volume-title":"Curr Opin Pulm Med","year":"2000"},{"key":"2026032606155120400_BIB3","first-page":"1343","volume-title":"Am J Respir Crit Care Med","year":"2001"},{"key":"2026032606155120400_BIB4","first-page":"S207","volume-title":"Am J Respir Crit Care Med","year":"2000"},{"key":"2026032606155120400_BIB5","first-page":"S176","volume-title":"Am J Respir Crit Care Med","year":"2000"},{"key":"2026032606155120400_BIB6","first-page":"1","volume-title":"Am J Respir Crit Care Med","year":"1998"},{"key":"2026032606155120400_BIB7","first-page":"28","volume-title":"Curr Opin Hematol","year":"2001"},{"key":"2026032606155120400_BIB8","first-page":"651","volume-title":"J Allergy Clin Immunol","year":"2000"},{"key":"2026032606155120400_BIB9","first-page":"21","volume-title":"Immunol Rev","year":"2000"},{"key":"2026032606155120400_BIB10","first-page":"19","volume-title":"Physiol Rev","year":"2002"},{"key":"2026032606155120400_BIB11","first-page":"517","volume-title":"Int J Immunopharmacol","year":"1997"},{"key":"2026032606155120400_BIB12","first-page":"407","volume-title":"Med Res Rev","year":"1996"},{"key":"2026032606155120400_BIB13","first-page":"642","volume-title":"Am J Respir Cell Mol Biol","year":"1997"},{"key":"2026032606155120400_BIB14","first-page":"284","volume-title":"Immunol Cell Biol","year":"1997"},{"key":"2026032606155120400_BIB15","first-page":"62","volume-title":"Semin Hematol","year":"2003"},{"key":"2026032606155120400_BIB16","first-page":"429","volume-title":"Cancer Invest","year":"2003"},{"key":"2026032606155120400_BIB17","first-page":"S77","volume-title":"Eur J Cancer","year":"2002"},{"key":"2026032606155120400_BIB18","first-page":"S19","volume-title":"Eur J Cancer","year":"2002"},{"key":"2026032606155120400_BIB19","first-page":"3391","volume-title":"Blood","year":"2003"},{"key":"2026032606155120400_BIB20","first-page":"23","volume-title":"Semin Cancer Biol","year":"2004"},{"key":"2026032606155120400_BIB21","first-page":"7830","volume-title":"Proc Natl Acad Sci USA","year":"2003"},{"key":"2026032606155120400_BIB22","first-page":"646","volume-title":"Am J Respir Cell Mol Biol","year":"1994"},{"key":"2026032606155120400_BIB23","first-page":"3945","volume-title":"J Immunol","year":"1996"},{"key":"2026032606155120400_BIB24","first-page":"1259","volume-title":"Am J Pathol","year":"1999"},{"key":"2026032606155120400_BIB25","first-page":"L1242","volume-title":"Am J Physiol Lung Cell Mol Physiol","year":"2001"},{"key":"2026032606155120400_BIB26","first-page":"313","volume-title":"J Exp Med","year":"1997"},{"key":"2026032606155120400_BIB27","first-page":"313","volume-title":"Curr Drug Targets Inflamm Allergy","year":"2003"},{"key":"2026032606155120400_BIB28","first-page":"911","volume-title":"Clin Exp Allergy","year":"2004"},{"key":"2026032606155120400_BIB29","first-page":"2160","volume-title":"J Immunol","year":"1999"},{"key":"2026032606155120400_BIB30","first-page":"7047","volume-title":"J Immunol","year":"1998"},{"key":"2026032606155120400_BIB31","first-page":"15","volume-title":"Clin Exp Immunol","year":"2004"},{"key":"2026032606155120400_BIB32","first-page":"279","volume-title":"J Allergy Clin Immunol","year":"2001"},{"key":"2026032606155120400_BIB33","first-page":"1887","volume-title":"Drugs","year":"2002"},{"key":"2026032606155120400_BIB34","first-page":"2083","volume-title":"Chest","year":"2003"},{"key":"2026032606155120400_BIB35","first-page":"499","volume-title":"Med Res Rev","year":"2001"},{"key":"2026032606155120400_BIB36","first-page":"410","volume-title":"Hematol J","year":"2003"},{"key":"2026032606155120400_BIB37","first-page":"3093","volume-title":"Blood","year":"2003"},{"key":"2026032606155120400_BIB38","first-page":"459","volume-title":"Cancer Cell","year":"2003"},{"key":"2026032606155120400_BIB39","first-page":"4660","volume-title":"Blood","year":"2003"},{"key":"2026032606155120400_BIB40","first-page":"4714","volume-title":"Blood","year":"2003"},{"key":"2026032606155120400_BIB41","first-page":"881","volume-title":"Leuk Res","year":"2002"},{"key":"2026032606155120400_BIB42","first-page":"9","volume-title":"MedGenMed","year":"2001"},{"key":"2026032606155120400_BIB43","first-page":"4291","volume-title":"Blood","year":"2002"},{"key":"2026032606155120400_BIB44","first-page":"168","volume-title":"Inflamm Res","year":"2001"},{"key":"2026032606155120400_BIB45","first-page":"245","volume-title":"J Exp Med","year":"1992"},{"key":"2026032606155120400_BIB46","first-page":"143","volume-title":"Cytokines Cell Mol Ther","year":"2002"},{"key":"2026032606155120400_BIB47","first-page":"754","volume-title":"Haematologica","year":"2003"},{"key":"2026032606155120400_BIB48","first-page":"2996","volume-title":"Cancer","year":"2002"},{"key":"2026032606155120400_BIB49","first-page":"538","volume-title":"Blood","year":"2004"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/171\/1\/35\/67490051\/ajrccm_171_1_35.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/171\/1\/35\/67490051\/ajrccm_171_1_35.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T10:15:59Z","timestamp":1774520159000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/171\/1\/35\/8537988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1,1]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2005,1,1]]},"published-print":{"date-parts":[[2005,1,1]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.200403-385oc","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2005,1]]},"published":{"date-parts":[[2005,1,1]]}}}