{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T23:02:09Z","timestamp":1774566129124,"version":"3.50.1"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>It has been suggested that patients with refractory eosinophilic airway inflammation represent a separate \u201ceosinophilic\u201d asthma phenotype associated with increased morbidity and a poor prognosis. To investigate whether persistent eosinophilia in these patients is a fixed feature or can still be modified by treatment, we investigated the effect of high-dose intramuscular corticosteroids on eosinophils in induced sputum. Twenty-two patients with stable severe asthma (15 women, aged 21\u201373 years) participated in this double-blind, placebo-controlled study. All were using inhaled corticosteroids (\u2a7e 1,600 \u03bcg\/day) or chronic oral prednisone. They were included if the percentage of eosinophils in induced sputum was above the upper limit of normal (\u2a7e 2%). Two weeks after treatment with triamcinolone, but not placebo, sputum eosinophils almost completely disappeared from a median of 12.6\u20130.2% (p &amp;lt; 0.001). In 82% of patients, no eosinophils could be observed at all. In addition, the rescue medication score decreased from 1.4 to 0.8 (p = 0.01), and FEV1 improved from a median of 73.8\u201388.3% predicted (p = 0.001). We conclude that persistent sputum eosinophilia despite extensive antiasthma treatment is not a refractory phenomenon but is still sensitive to high-dose systemic corticosteroids. This implies that these patients with severe asthma need additional or alternative antiinflammatory treatment to combat the eosinophilia and associated poor prognosis.<\/jats:p>","DOI":"10.1164\/rccm.200404-440oc","type":"journal-article","created":{"date-parts":[[2004,6,23]],"date-time":"2004-06-23T20:20:29Z","timestamp":1088022029000},"page":"601-605","source":"Crossref","is-referenced-by-count":178,"title":["\u201cRefractory\u201d Eosinophilic Airway Inflammation in Severe Asthma"],"prefix":"10.1093","volume":"170","author":[{"given":"Anneke","family":"ten Brinke","sequence":"first","affiliation":[{"name":"Department of Pulmonary Diseases, Leeuwarden Medical Center, Leeuwarden; Department of Biostatistics, Amsterdam Medical Center, Amsterdam; and Department of Pulmonary Diseases, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aeilko H.","family":"Zwinderman","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases, Leeuwarden Medical Center, Leeuwarden; Department of Biostatistics, Amsterdam Medical Center, Amsterdam; and Department of Pulmonary Diseases, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Sterk","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases, Leeuwarden Medical Center, Leeuwarden; Department of Biostatistics, Amsterdam Medical Center, Amsterdam; and Department of Pulmonary Diseases, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus F.","family":"Rabe","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases, Leeuwarden Medical Center, Leeuwarden; Department of Biostatistics, Amsterdam Medical Center, Amsterdam; and Department of Pulmonary Diseases, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth H.","family":"Bel","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases, Leeuwarden Medical Center, Leeuwarden; Department of Biostatistics, Amsterdam Medical Center, Amsterdam; and Department of Pulmonary Diseases, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2004,9,15]]},"reference":[{"key":"2026032606320274400_BIB1","first-page":"49S","volume-title":"Am J Med","year":"2003"},{"key":"2026032606320274400_BIB2","first-page":"201","volume-title":"Clin Sci 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