{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:28:38Z","timestamp":1791347318382,"version":"4.3.1"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>There is little published information regarding treatment completion, safety, and efficacy of rifampin administered daily for 4 months\u2014a recommended alternative to 9 months of isoniazid for therapy of latent tuberculosis infection. In an open-label randomized trial at a university-affiliated respiratory hospital, consenting patients whose treating physician had recommended therapy for latent tuberculosis infection were randomized to daily self-administered rifampin for 4 months or daily self-administered isoniazid for 9 months. Of 58 patients randomized to rifampin, 53 (91%) took 80% of doses, and 50 (86%) took more than 90% of doses within 20 weeks compared with 44 (76%) and 36 (62%) who took 80 and 90%, respectively, of doses of isoniazid within 43 weeks (relative risks: 80% of doses, 1.2 [95% confidence interval: 1.02, 1.4]; 90% of doses, 1.4 [1.1, 1.7]). Adverse events resulted in permanent discontinuation of therapy for two (3%) patients taking rifampin, and for eight (14%) patients taking isoniazid. Three patients developed drug-induced hepatitis\u2014all were taking isoniazid. Total costs of therapy were significantly higher for isoniazid. In conclusion, completion of therapy was significantly better with 4 months of rifampin and major side effects were somewhat lower. Further studies are needed to assess the safety and efficacy of the 4-month rifampin regimen.<\/jats:p>","DOI":"10.1164\/rccm.200404-478oc","type":"journal-article","created":{"date-parts":[[2004,6,7]],"date-time":"2004-06-07T20:29:28Z","timestamp":1086640168000},"page":"445-449","source":"Crossref","is-referenced-by-count":129,"title":["Treatment Completion and Costs of a Randomized Trial of Rifampin for 4 Months versus Isoniazid for 9 Months"],"prefix":"10.1093","volume":"170","author":[{"given":"Dick","family":"Menzies","sequence":"first","affiliation":[{"name":"Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, and Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Jose\u0301e","family":"Dion","sequence":"additional","affiliation":[{"name":"Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, and Division 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Epidemiology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Schwartzman","sequence":"additional","affiliation":[{"name":"Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, and Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,8,15]]},"reference":[{"key":"2026032606274592300_BIB1","first-page":"761","volume-title":"Ann Intern Med","year":"1971"},{"key":"2026032606274592300_BIB2","first-page":"1357","volume-title":"Am Rev Respir 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