{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:43:43Z","timestamp":1789879423058,"version":"4.0.1"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale and Objectives<\/jats:title>\n                    <jats:p>Farmers experience airway obstruction, which may be attributable in part to endotoxin inhalation. CD14 is a receptor for endotoxin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Based on our findings of increased circulating CD14 associated with the CD14\/\u2212159 T allele, we hypothesized that carriers of this allele would have decreased lung function among endotoxin-exposed individuals. CD14\/\u2212159TT farmers (n = 19) had significantly lower lung function as measured by FEV1 (p = 0.028) and mean forced expiratory flow during the middle half of the FVC (FEF25\u201375) (p = 0.05) compared with farmers with the C allele (n = 78). Also, farmers with the CD14\/\u22121619GG genotype (n =11) were associated with lower lung function (FEV1, p = 0.008; FEF25\u201375, p = 0.009) compared with farmers with the A allele (n = 86).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No association between CD14\/\u2212550 and lung function was observed (FEV1, p = 0.32; FEF25\u201375, p = 0.11). Increased prevalence of wheezing was reported in farmers homozygous for CD14\/\u2212159T (p = 0.013) or CD14\/\u22121619G (p = 0.019) compared with farmers with the CC or AA genotype, respectively. No association was found between TLR4\/Asp299Gly and lung function or wheeze.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We conclude that the CD14\/\u2212159 or CD14\/\u22121619 loci may play a role in modulating lung function and wheeze among agricultural workers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1164\/rccm.200404-530oc","type":"journal-article","created":{"date-parts":[[2005,3,24]],"date-time":"2005-03-24T18:28:29Z","timestamp":1111688909000},"page":"773-779","source":"Crossref","is-referenced-by-count":63,"title":["Polymorphisms in the CD14 Gene Associated with Pulmonary Function in Farmers"],"prefix":"10.1093","volume":"171","author":[{"given":"Tricia D.","family":"LeVan","sequence":"first","affiliation":[{"name":"Arizona Respiratory Center and Departments of Internal Medicine and Pediatrics, College of Medicine, University of Arizona, Tucson, Arizona; Department of Exercise Science and Athletic Training, Creighton University; Department of Internal Medicine, Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha, Nebraska; and Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Von Essen","sequence":"additional","affiliation":[{"name":"Arizona Respiratory Center and Departments of Internal Medicine and Pediatrics, College of Medicine, University of Arizona, Tucson, Arizona; Department of Exercise Science and Athletic Training, Creighton University; Department of Internal Medicine, Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha, Nebraska; and Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra J.","family":"Romberger","sequence":"additional","affiliation":[{"name":"Arizona Respiratory Center and Departments of Internal Medicine and Pediatrics, College of Medicine, University of Arizona, Tucson, Arizona; Department of Exercise Science and Athletic Training, Creighton University; Department of Internal Medicine, Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha, Nebraska; and Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Patrick","family":"Lambert","sequence":"additional","affiliation":[{"name":"Arizona Respiratory Center and Departments of Internal Medicine and Pediatrics, College of Medicine, University of Arizona, Tucson, Arizona; Department of Exercise Science and Athletic Training, Creighton University; Department of Internal Medicine, Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha, Nebraska; and Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando D.","family":"Martinez","sequence":"additional","affiliation":[{"name":"Arizona Respiratory Center and Departments of Internal Medicine and Pediatrics, College of Medicine, University of Arizona, Tucson, Arizona; Department of Exercise Science and Athletic Training, Creighton University; Department of Internal Medicine, Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha, Nebraska; and Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica M.","family":"Vasquez","sequence":"additional","affiliation":[{"name":"Arizona Respiratory Center and Departments of Internal Medicine and Pediatrics, College of Medicine, University of Arizona, Tucson, Arizona; Department of Exercise Science and Athletic Training, Creighton University; Department of Internal Medicine, Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha, Nebraska; and Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Merchant","sequence":"additional","affiliation":[{"name":"Arizona Respiratory Center and Departments of Internal Medicine and Pediatrics, College of Medicine, University of Arizona, Tucson, Arizona; Department of Exercise Science and Athletic Training, Creighton University; Department of Internal Medicine, Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha, Nebraska; and Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,4,1]]},"reference":[{"key":"2026032606202279900_BIB1","first-page":"11","volume-title":"Immunol Today","year":"1992"},{"key":"2026032606202279900_BIB2","first-page":"49","volume-title":"J Occup Med","year":"1994"},{"key":"2026032606202279900_BIB3","first-page":"33","volume-title":"Am J Ind Med","year":"1996"},{"key":"2026032606202279900_BIB4","first-page":"119","volume-title":"Ann Agric Environ Med","year":"2002"},{"key":"2026032606202279900_BIB5","first-page":"e3","volume-title":"Occup 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