{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T15:09:29Z","timestamp":1791126569893,"version":"4.1.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Distinct phenotypes can be identified in childhood wheezing illness. Within the context of a birth cohort study, we investigated the association between preschool lung function and phenotypes of wheeze. From parentally reported history of wheeze (interviewer-administered questionnaire, age 3 and 5 years), children were classified as never wheezers, transient early wheezers, late-onset wheezers, or persistent wheezers. Lung function (specific airway resistance [sRaw]; kPa\/second) was assessed at age 3 (n = 463) and 5 years (n = 690). Persistent wheezers had markedly poorer lung function compared with other groups. In children who had wheezed by age 3, the risk of persistent wheeze increased with increased sRaw (odds ratio [OR] 5.2, 95% confidence interval [CI] 1.3\u201322.0; p = 0.02). In a multivariate model, increasing sRaw (OR 5.5, 95% CI 1.2\u201325.9; p = 0.03) and the child's sensitization (OR 2.8, 95% CI 1.3\u20135.8; p = 0.008) were significant independent predictors of persistent wheezing. We found no association between lung function at age 3 and late-onset wheeze in children who had not wheezed previously (OR 0.6, 95% CI 0.07\u20135.3; p = 0.64). In conclusion, poor lung function at age 3 predicted the subsequent persistence of symptoms in children who had wheezed within the first 3 years, but was not associated with the onset of wheeze after age 3 in children who had not wheezed previously.<\/jats:p>","DOI":"10.1164\/rccm.200406-695oc","type":"journal-article","created":{"date-parts":[[2004,10,22]],"date-time":"2004-10-22T20:25:09Z","timestamp":1098476709000},"page":"231-237","source":"Crossref","is-referenced-by-count":175,"title":["Wheeze Phenotypes and Lung Function in Preschool Children"],"prefix":"10.1093","volume":"171","author":[{"given":"Lesley A.","family":"Lowe","sequence":"first","affiliation":[{"name":"North West Lung Centre and Department of Medical Statistics, Wythenshawe Hospital, Manchester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Simpson","sequence":"additional","affiliation":[{"name":"North West Lung Centre and Department of Medical Statistics, Wythenshawe Hospital, Manchester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Woodcock","sequence":"additional","affiliation":[{"name":"North West Lung Centre and Department of Medical Statistics, Wythenshawe Hospital, Manchester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Morris","sequence":"additional","affiliation":[{"name":"North West Lung Centre and Department of Medical Statistics, Wythenshawe Hospital, Manchester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare S.","family":"Murray","sequence":"additional","affiliation":[{"name":"North West Lung Centre and Department of Medical Statistics, Wythenshawe Hospital, Manchester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Custovic","sequence":"additional","affiliation":[{"name":"North West Lung Centre and Department of Medical Statistics, 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