{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:17:34Z","timestamp":1791181054742,"version":"4.1.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Interleukin (IL)-17F is a recently described human cytokine belonging to the IL-17 gene family, but its in vivo function remains to be determined. To this end, a full-length mouse IL-17F cDNA sequence with a 483-bp coding region sequence was first identified. Pulmonary gene transfer of an IL-17F expression construct (pcDNAmIL-17F) in mice was used to investigate its regulatory role. The results showed first that a significant increase in the number of neutrophils was seen in the bronchoalveolar lavage fluids of IL-17F\u2013transduced mice, concomitant with increased expression of genes encoding C-X-C chemokines and inflammatory cytokines when compared with mock and phosphate-buffered saline control animals. Mucosal transfer of the IL-17F gene in ovalbumin (OVA)-sensitized mice before antigen (Ag) challenge enhanced the levels of Ag-induced pulmonary neutrophilia, but not eosinophilia, goblet cell hyperplasia, and mucin gene expression. However, no significant change in the levels of Th2 cytokine expression was noted. A significant enhancement of ventilatory timing in response to inhaled methacholine was also seen in IL-17F\u2013transduced, Ag-sensitized mice, whereas a small but significant increase was found in IL-17F\u2013transduced, naive mice. These results suggest a role for IL-17F in the induction of neutrophilia in the lungs and in the exacerbation of Ag-induced pulmonary inflammation.<\/jats:p>","DOI":"10.1164\/rccm.200406-778oc","type":"journal-article","created":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T20:14:40Z","timestamp":1097525680000},"page":"12-18","source":"Crossref","is-referenced-by-count":120,"title":["Interleukin-17F Induces Pulmonary Neutrophilia and Amplifies Antigen-induced Allergic Response"],"prefix":"10.1093","volume":"171","author":[{"given":"Naruhito","family":"Oda","sequence":"first","affiliation":[{"name":"Johns Hopkins Asthma and Allergy Center, Baltimore; and Food and Drug Administration, Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola B.","family":"Canelos","sequence":"additional","affiliation":[{"name":"Johns Hopkins Asthma and Allergy Center, Baltimore; and Food and Drug Administration, Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Essayan","sequence":"additional","affiliation":[{"name":"Johns Hopkins Asthma and Allergy Center, Baltimore; and Food and Drug Administration, Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly A.","family":"Plunkett","sequence":"additional","affiliation":[{"name":"Johns Hopkins Asthma and Allergy Center, Baltimore; and Food and Drug Administration, Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen C.","family":"Myers","sequence":"additional","affiliation":[{"name":"Johns Hopkins Asthma and Allergy Center, Baltimore; and Food and Drug Administration, Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shau-Ku","family":"Huang","sequence":"additional","affiliation":[{"name":"Johns Hopkins Asthma and Allergy Center, Baltimore; and Food and Drug Administration, Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,1,1]]},"reference":[{"key":"2026032606160117000_BIB1","first-page":"155","volume-title":"Cytokine Growth Factor Rev","year":"2003"},{"key":"2026032606160117000_BIB2","first-page":"1","volume-title":"J Leukoc Biol","year":"2002"},{"key":"2026032606160117000_BIB3","first-page":"4430","volume-title":"J Immunol","year":"2001"},{"key":"2026032606160117000_BIB4","first-page":"5332","volume-title":"EMBO J","year":"2001"},{"key":"2026032606160117000_BIB5","first-page":"4137","volume-title":"J Immunol","year":"2001"},{"key":"2026032606160117000_BIB6","first-page":"15229","volume-title":"J Biol Chem","year":"2002"},{"key":"2026032606160117000_BIB7","first-page":"1213","volume-title":"J Pharmacol Exp Ther","year":"2003"},{"key":"2026032606160117000_BIB8","first-page":"117","volume-title":"Allergol Int","year":"2003"},{"key":"2026032606160117000_BIB9","first-page":"3216","volume-title":"J Immunol","year":"1996"},{"key":"2026032606160117000_BIB10","first-page":"438","volume-title":"J Clin Invest","year":"1998"},{"key":"2026032606160117000_BIB11","first-page":"11","volume-title":"Allergol Int","year":"1997"},{"key":"2026032606160117000_BIB12","first-page":"A360","volume-title":"Am J Respir Crit Care Med","year":"2003"},{"key":"2026032606160117000_BIB13","first-page":"3025","volume-title":"J Immunol","year":"2001"},{"key":"2026032606160117000_BIB14","first-page":"828","volume-title":"J Appl Physiol","year":"2003"},{"key":"2026032606160117000_BIB15","first-page":"519","volume-title":"J Exp Med","year":"2001"},{"key":"2026032606160117000_BIB16","first-page":"2347","volume-title":"J Immunol","year":"1999"},{"key":"2026032606160117000_BIB17","first-page":"1445","volume-title":"Am J Respir Crit Care Med","year":"2002"},{"key":"2026032606160117000_BIB18","first-page":"1164","volume-title":"Am J Respir Crit Care Med","year":"2004"},{"key":"2026032606160117000_BIB19","first-page":"286","volume-title":"J Appl Physiol","year":"2004"},{"key":"2026032606160117000_BIB20","first-page":"373","volume-title":"Am J Respir Cell Mol Biol","year":"2004"},{"key":"2026032606160117000_BIB21","first-page":"387","volume-title":"Eur Respir J","year":"2003"},{"key":"2026032606160117000_BIB22","first-page":"83","volume-title":"Am J Respir Crit Care Med","year":"2003"},{"key":"2026032606160117000_BIB23","first-page":"419","volume-title":"Am J Respir Cell Mol Biol","year":"2002"},{"key":"2026032606160117000_BIB24","first-page":"443","volume-title":"J Immunol","year":"2002"},{"key":"2026032606160117000_BIB25","first-page":"17036","volume-title":"J Biol Chem","year":"2003"},{"key":"2026032606160117000_BIB26","first-page":"306","volume-title":"Am J Respir Crit Care Med","year":"2004"}],"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/171\/1\/12\/67490043\/ajrccm_171_1_12.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/171\/1\/12\/67490043\/ajrccm_171_1_12.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T10:16:07Z","timestamp":1774520167000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/171\/1\/12\/8537993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1,1]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2005,1,1]]},"published-print":{"date-parts":[[2005,1,1]]}},"URL":"https:\/\/doi.org\/10.1164\/rccm.200406-778oc","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2005,1]]},"published":{"date-parts":[[2005,1,1]]}}}